Protein Alignment RhoGAP102A and BEM3

DIOPT Version :9

• Sequence 1: NP_001245416.1
• Gene: RhoGAP102A / 43781
• FlyBaseID: FBgn0259216
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: NP_015210.1
• Gene: BEM3 / 855988
• SGDID: S000006036
• Length: 1128
• Species: Saccharomyces cerevisiae
• Alignment Length: 1200
• Identity: 226/1200 - (18%)
• Similarity: 375/1200 - (31%)
• Gaps: 404/1200 - (33%)

  Fly     6 ENEESVNCLRSPMAAVKKRSGPLDIALDEANDVSKIWSLP----LGNASSMRK---PMIFAS--E 61
            |.:..:..|..|:..:   |.||....|.|.:.|...::|    ..|.|..||   .||...  |
Yeast   117 ERKAHIKSLNLPIPTL---SPPLQQGSDVALETSVTPTVPQIGVTSNTSISRKHLQNMILNDEIE 178

  Fly    62 HSEGVASPNKVRRRSTKDKEKKRERWLLTRKTWRYMTDAGRKLIPDGYQTGSGNHDLIEDQFQRV 126
            .:...:||..:.|..:...:...|:......:..|.|                         .|:
Yeast   179 ANSSFSSPKIINRSVSSPTKIHSEQLASPAASVTYTT-------------------------SRI 218

  Fly   127 CLSEPSFILWSRRTSYPGAFSCSKRRLKPLLRHASASRRKQTVDATKDYHIADRVIELLQTYLKL 191
            .:..|                 :|....||.....:.:....:.|..:.|        |.:.||
Yeast   219 TIKSP-----------------NKGSKSPLQERLRSPQNPNRMTAVINNH--------LHSPLK- 257

  Fly   192 RDAYKTTTLLGTKTVRPDQTSSPSAQRPN---FKNNGDNHQVISSG------TSIQTELLSLLKL 247
                     ..|.....:.|.|.|.|..|   .||:.....:.||.      ||......|||::
Yeast   258 ---------ASTSNNLDELTESKSQQLTNDAIQKNDRVYSSITSSAYTTGTPTSAAKSPSSLLEV 313

  Fly   248 LSNCPLFTHEGIQLKFGDAPLSILEDKVLLKKIYSALKKQQLHRTLHSKDPYQAN---------- 302
            ...      |...|.|..|....|:|...|  :.|:..::.|..| .||||....
Yeast   314 KEG------ENKALGFSPASKEKLDDFTQL--LDSSFGEEDLVNT-DSKDPLSIKSTINESLPPP 369

  Fly   303 ------FSTSLSCLIKNGKELSRGNTDSNRSNKLLHDNFFC-LMKCDTKPIIPSPKTEFFLDLNK 360
                  ||.:.|..|||...||.........|| ..|||.. ..|...||::.|........|:.
Yeast   370 PAPPTFFSPTSSGNIKNSTPLSSHLASPVILNK-KDDNFGAQSAKNLKKPVLTSSLPNLSTKLST 433

  Fly   361 VPQNFEL-----------------------KNKLNS---------------NGQSVERIQKTCGT 387
            ..||..|                       .|.||:               :..||..::....:
Yeast   434 TSQNASLPPNPPVESSSKQKQLGETASIHSTNTLNTFSSTPQGSLKTLRRPHASSVSTVKSVAQS 498

  Fly   388 QTN----FIQLSELKTLAEQYNLMVT----NCDN---TLKLLEEPSKQDCSKSSHLIFRRSSLDE 441
            ..:    |:|..:..|:  |..::.|    |.|:   .:.:::..|.::..|.|..|.:...||.
Yeast   499 LKSDIPLFVQPEDFGTI--QIEVLSTLYRDNEDDLSILIAIIDRKSGKEMFKFSKSIHKVRELDV 561

  Fly   442 DISQSVSD-------------TIKRYLNMARKKSMQDSDSNRFKSINYDKNL-----RNIKAKGV 488
            .:...|.|             |:.......||..:....::.|....:.||:     :.|....|
Yeast   562 YMKSHVPDLPLPTLPDRQLFQTLSPTKVDTRKNILNQYYTSIFSVPEFPKNVGLKIAQFISTDTV 626

  Fly   489 LNPP----GISAG--LHKAVQTL---NAWPLIALDFIRGNESSLNLKNAHLEWLRLEDERSHMQL 544
            :.||    .:..|  |.:..:||   :.| .:....:|.:...|..||...|.::|  .:|.::|
Yeast   627 MTPPMMDDNVKDGSLLLRRPKTLTGNSTW-RVRYGILRDDVLQLFDKNQLTETIKL--RQSSIEL 688

  Fly   545 ------------------ERDKNPIELRSK---------------------VNPLQIASPANTSS 570
                              |..|:.:...:|                     ::|.|..|.:::.:
Yeast   689 IPNLPEDRFGTRNGFLITEHKKSGLSTSTKYYICTETSKERELWLSAFSDYIDPSQSLSLSSSRN 753

  Fly   571 YSKCTSAP--TSPTSHSKLEKAIRTSSGLLSSSSQFISNILHGHNNAGNQFNTLTDKLPDCNQSH 633
            .:...||.  ::.|.|||...|..::    :.:..:::::...:||..|..|:..      |.::
Yeast   754 ANDTDSASHLSAGTHHSKFGNATISA----TDTPSYVTDLTQEYNNNNNISNSSN------NIAN 808

  Fly   634 ATASMQKSKSLSNVGQFVAKRMWRSRSKSQNKRSYLKSSIPTLKWYPSEHFLWISESGESFQIVE 698
            :........|.||   |:|.....:..:..::|:.::|..|..|
Yeast   809 SDGIDSNPSSHSN---FLASSSGNAEEEKDSRRAKMRSLFPFKK--------------------- 849

  Fly   699 TNLTRLSKIESDIVKNFALEKIQELNIGNIEDLKISPQKRRCVPKKKSLTTSFFDNGKKDDQNPR 763
              ||..:...:.|          .:.|.|..|...||......|.||.:..|...| .....:..
Yeast   850 --LTGPASAMNHI----------GITISNDSDSPTSPDSIIKSPSKKLMEVSSSSN-SSTGPHVS 901

  Fly   764 SVLFGTSLECCLERDSKRNVTMEDRSKYSLLSMFRGSGSTPGSVLKLNDNVRSCESLPSKSLEYG 828
            :.:||:|||.||...|.:...:.|
Yeast   902 TAIFGSSLETCLRLSSHKYQNVYD----------------------------------------- 925

  Fly   829 STELSAYVRGSFSNISKPLASLSQSENEDTELNFVKAYQEHSQLMVPIFVNNCIDYLEDN-GLQQ 892
                                                         :|..|..|::||..| |:|:
Yeast   926 ---------------------------------------------LPSVVYRCLEYLYKNRGIQE 945

  Fly   893 VGLFRVSTSKKRVKQLREEFDKDIYFGISVDTCPHD--------------------VATLLKEFL 937
            .|:||:|.|...:|.|:|.|||:    ..||.|.::                    |:.|||.:|
Yeast   946 EGIFRLSGSSTVIKTLQERFDKE----YDVDLCRYNESIEAKDDEASPSLYIGVNTVSGLLKLYL 1006

  Fly   938 RDLPEPLLCNTLYLTFLK-TQRIRNRRLQLE-AISHLIRLLPIPHRD--TLYVLLVFLAKVAAHS 998
            |.||..|..:..:|:|.: .....|..:|:. ....||....:||.:  .:|.|...|.::..:|
Yeast  1007 RKLPHLLFGDEQFLSFKRVVDENHNNPVQISLGFKELIESGLVPHANLSLMYALFELLVRINENS 1071

  Fly   999 DDIWSTEGCCLTLGNKMDSYNLATVFAPNI 1028
            .            .|||:..||..||:|.:
Yeast  1072 K------------FNKMNLRNLCIVFSPTL 1089

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP102A	NP_001245416.1	RhoGAP	874..1069	CDD:295372	51/179 (28%)
BEM3	NP_015210.1	PX	520..622	CDD:214610	17/101 (17%)
		PH_Bem3	633..741	CDD:270096	16/110 (15%)
		RhoGAP	904..1110	CDD:413382	60/287 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I1561
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960