DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP102A and Arhgap36

DIOPT Version :9

Sequence 1:	NP_001245416.1	Gene:	RhoGAP102A / 43781	FlyBaseID:	FBgn0259216	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	XP_017174121.1	Gene:	Arhgap36 / 75404	MGIID:	1922654	Length:	602	Species:	Mus musculus

Alignment Length:	615	Identity:	154/615 - (25%)
Similarity:	245/615 - (39%)	Gaps:	150/615 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   589 KAIRTSSG------LLSSSSQFISNILHGHNNAGNQFNTLTDKLPDCNQSHATASMQKSKSLSNV 647
            |||||...      ||.|:..|:.::|.|.....      :|:..|....|:.:.:::.|.....
Mouse     9 KAIRTRCPIIIPFLLLLSAFIFLVSVLGGAPGQN------SDRSMDMVSIHSLSELERLKLQETA 67

  Fly   648 GQFVAKRMWRSRSKSQNKRSYLKSSIPT------LKWYPSEHFLWI-----SESGESFQIVETNL 701
            ...:..|.:.|..|...       ::||      .||     ||.:     :.|.::|.|
Mouse    68 YHELVARHFLSEFKPDR-------ALPTDRPNTLEKW-----FLMLRGQDRAASLKTFGI----- 115

  Fly   702 TRLSKIESDIVKNFALEKIQELN-IGNIEDLKISPQKRR---CVPKKKSLTTSFFDNGKKDDQNP 762
                ::|..:|......|.:||. ...:||:..|..:||   .|.:.......||...:.:...|
Mouse   116 ----RLEEVLVNELTRRKQRELTPTMQVEDINGSTGRRRRGNVVQRMLGRMRRFFSRRRNEPTLP 176

  Fly   763 RSVLFGTSLECCLERDSKRNVTMEDRSKYSLLSMFRGSGSTPGSVLKLNDNVRSCESLPSKSLEY 827
            |.          ..|..:|.....|                                 .:..||.
Mouse   177 RE----------FTRRGRRGAVSAD---------------------------------SADELEN 198

  Fly   828 GSTELSAYVRGSFSNISKPLASLSQSENEDTELNFVKAYQEHSQLMVPIFVNNCIDYLEDNGLQQ 892
            |:..|...   ..|.:|.|:............||.: |.|      :|..|..|..::|.:||..
Mouse   199 GALLLQIL---QLSQLSSPIGQRLLGSKRKMSLNPI-AQQ------IPQIVETCCKFIEKHGLSS 253

  Fly   893 VGLFRVSTSKKRVKQLREEFDK--DIYFGISVDTCPHDVATLLKEFLRDLPEPLLCNTLYLTFLK 955
            ||:|.:..|.:||.:|||.|||  ||....||:.  ||||.|||||.|::.:|||.:.||::||.
Mouse   254 VGIFTIEYSLRRVLELRELFDKGLDIVLDDSVNV--HDVAELLKEFFREMKDPLLPDDLYMSFLL 316

  Fly   956 TQRIRNRRLQLEAISHLIRLLPIPHRDTLYVLLVFLAKVAAHSDDIWSTEGCCLTLGNKMDSYNL 1020
            |..::.:. |:.|:..|:.|:|..|.|||..||..|.|:..:.:|....:| .|..||:|.|.||
Mouse   317 TATLKPKD-QVSALQLLVYLMPPCHSDTLERLLKALHKITENCEDSIGVDG-QLVPGNRMTSTNL 379

  Fly  1021 ATVFAPNILRSTHLTFSRDKEQENMID----AINVVRTMINHYEEIFNISAELLNVIYTQALEAC 1081
            |.||...:|:...|.....::.:..||    ::||||.||::::.:|.:...:...:..:..::.
Mouse   380 ALVFGTALLKKGKLANKESRKTKLGIDHYVASVNVVRAMIDNWDILFQVPPHIQKEVAKRVWKSS 444

  Fly  1082 PE------------------KLYE--LISTKVYGTEWTQ-------QQIDDPQPGSLSDVLLEPP 1119
            ||                  |:.|  |:|..|..:...|       |..|:...|:       |.
Mouse   445 PEALDFIRRRNLRKIQSARIKMEEDALLSDPVENSAEAQAAILAQSQPFDEDPEGA-------PD 502

  Fly  1120 IHGKRYENINDFNNINFKRCQD-KRRDHSD 1148
            :|    |.:||..|.:|:...| :.:||.|
Mouse   503 VH----EVLNDNLNYDFEDESDFEDQDHLD 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP102A	NP_001245416.1	RhoGAP	874..1069	CDD:295372	76/200 (38%)
Arhgap36	XP_017174121.1	RhoGAP_ARHGAP6	227..432	CDD:239841	80/215 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836915
Domainoid	1	1.000	142	1.000	Domainoid score	I4667
eggNOG	1	0.900	-	-		E1_KOG2710
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44143
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12635
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.840