DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP102A and Arhgap11a

DIOPT Version :9

Sequence 1:	NP_001245416.1	Gene:	RhoGAP102A / 43781	FlyBaseID:	FBgn0259216	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_852081.2	Gene:	Arhgap11a / 228482	MGIID:	2444300	Length:	987	Species:	Mus musculus

Alignment Length:	465	Identity:	115/465 - (24%)
Similarity:	180/465 - (38%)	Gaps:	133/465 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   826 EYGSTELSAYVRGSFSNISKPLASLSQSENEDTELNFVKAYQEHSQLMVPIF-------VNNCID 883
            |..:||:...|.|      .|..||..|                   :||.|       |:.|..
Mouse    36 ETAATEIKGKVFG------VPFNSLPHS-------------------VVPEFGHIPSFLVDACAS 75

  Fly   884 YLEDNGLQQVGLFRVSTSKKRVKQLREEFDKDIYFGISVDTC-----PHDVATLLKEFLRDLPEP 943
            ..|.  :...||||.|.|..|:|.|:.:.|:.       :.|     |.|||.|||:|.|:||||
Mouse    76 LKEH--IHTEGLFRKSGSVVRLKALKSKLDQG-------EACLSSALPCDVAGLLKQFFRELPEP 131

  Fly   944 LLCNTLYLTFLKTQRI----RNRRLQLEAISHLIRLLPIPHRDTLYVLLVFLAKVAAHSDDIWST 1004
            :|...|:....|.|::    ||:...|     |..|:..|..|.|.....||..|:..:.:
Mouse   132 VLPADLHEALFKAQQLGAEERNKATLL-----LSCLMANPTVDILRYFFNFLKSVSLRASE---- 187

  Fly  1005 EGCCLTLGNKMDSYNLATVFAPNILRST--HLTFSRDKEQENMIDAINVVRTMINHYEEIFNISA 1067
                    |||||.|||.:||||:|:::  |...|.:.|::..:.|. ||:|.|:...:|..:
Mouse   188 --------NKMDSSNLAVIFAPNLLQTSEGHEKMSANTEKKLRLQAA-VVQTFIDCASDIGRV-- 241

  Fly  1068 ELLNVIYTQALEACPEKLYELISTKVYGTEWTQQQIDDPQPGSLSDVLLEPPIHG---------- 1122
                          |:.:.|.|                |....:..:...|.:.|
Mouse   242 --------------PDFILEKI----------------PAMLGIDGLCTTPSLEGFEGDFETPGE 276

  Fly  1123 ---KRYENINDFNNINFKRCQDKRRDHSDP--DKKKNNNENLEIITASLKISV-AEQSHI---SL 1178
               ||.:::.||.|....:.:..|.....|  |:....:.:..|:|.|:|..: .|.||.   ..
Mouse   277 CKRKRRQSVGDFVNGALNKLKSSRTPSITPQQDRTAQASASPLILTPSVKRKLPGESSHAFSSKK 341

  Fly  1179 KEPIKEQ---EPITSYKQFSRSTLPTSISDVGVNTLRTDGAKLENKMKILTSNINKQDIPIKTTY 1240
            ::.||..   |.:.|: .||.::.|.|   |.::| ..||:...:...|..|..:.    :.|..
Mouse   342 RKSIKHNLNFELLPSH-FFSSNSTPVS---VHLDT-SPDGSSQTSLSPIAMSGNHL----VSTEL 397

  Fly  1241 KRQNLISSSR 1250
            :|...|:|.:
Mouse   398 RRSKRIASKK 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP102A	NP_001245416.1	RhoGAP	874..1069	CDD:295372	67/212 (32%)
Arhgap11a	NP_852081.2	RhoGAP-ARHGAP11A	46..246	CDD:239859	74/267 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..341		10/43 (23%)
		SH3-RhoG_link	371..>464	CDD:293215	9/42 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	632..669
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	700..756
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	960..987
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2710
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810