Protein Alignment RhoGAP102A and rga-6

DIOPT Version :10

• Sequence 1: NP_001245416.1
• Gene: RhoGAP102A / 43781
• FlyBaseID: FBgn0259216
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: NP_491465.2
• Gene: rga-6 / 172102
• WormBaseID: WBGene00015303
• Length: 986
• Species: Caenorhabditis elegans
• Alignment Length: 916
• Identity: 246/916 - (26%)
• Similarity: 380/916 - (41%)
• Gaps: 184/916 - (20%)

  Fly   421 PSKQDCSKSSHLIFRRSSLDEDI-----SQSVSDTIKRYLNMARKKSMQDSDSNRFKSINYDKNL 480
            ||....||:| :...||..|..|     |.:.|.:|.|.|    .:|...|:|.:..|::..|:.
 Worm    28 PSSSPKSKTS-VTSSRSDTDSVIPEHKPSSASSFSIGRLL----FRSSGSSNSTKRDSVDSGKDD 87

  Fly   481 RNIKAKGVLNPPGISAGLHKAVQTLNA---------------WPLIALDFIRGNESSLNLKNAHL 530
            ...::.....|...:.|..|:.|...:               |.|.......|::.| ::|...|
 Worm    88 ETGRSPATSRPGSPNPGGDKSPQMSTSRRLAGFASRSIRKSQWRLFKHRTFFGSQRS-SMKKNQL 151

  Fly   531 EWLRLEDERSHMQLERDKNPIELRSKVNP--------LQIASPANTSSYSKCTSAPTS------- 580
            :..||  ...|..::....|::|....|.        |||    ..|:..:.|.:.|:
 Worm   152 QLPRL--TLRHPSIDSSAMPLQLDVDENASGEGSDDFLQI----RRSTQRRWTDSDTTGRLRDSR 210

  Fly   581 -----PTSHSKLEKAIRTSSGLLSSSSQFISNILHGHNNAGNQFNTLTDKLP-DCNQSHATASMQ 639
                 ..||..|:.|..::.|:..|||       |.|:|. :....::..:| ..:.||:.....
 Worm   211 DSSDFNDSHDTLDIAGTSAHGVADSSS-------HHHHNY-SMTAPVSPNVPLSASSSHSEGWKY 267

  Fly   640 KSKSLSNVGQFVAKRMWRSRSKSQNKRSYLKSSIPTLKWYPSEHFLWISESGESFQIVETNLTRL 704
            .|:.|          :|:.:.|.....:...||.....|...:...|.|..|....:....|..|
 Worm   268 SSQKL----------LWKLKPKYAYSHASSTSSSTDSAWKSLDSMTWRSVDGAEVVLRGARLENL 322

  Fly   705 SKIESDIVKNFALEKIQEL----NIGNIEDLKISPQKRRCVPKKKSLTTSFFDNGKKDDQNP--- 762
            |:||...::..|.:::.::    |:|..:.|:   |||:.: .|.:.|.:..|..::....|
 Worm   323 SEIERSALQLLAAQRLTKMLPGVNLGKPKALR---QKRQKL-VKSNRTPTVADVQRRASGTPMPE 383

  Fly   763 RSVLFGTSLECC------LERDSK------RNVTMEDRSKY-----------------------S 792
            ...:||.||..|      |:::|:      ..|.|.::||.                       |
 Worm   384 EKRVFGVSLAMCMLNEKRLDQESRCRSLDDSTVIMLNKSKAKPTKSEPEMMSHTMPEDRKWLYPS 448

  Fly   793 LLSMFRGSGSTPGSVLKLNDNVRSCES-LPSKSLEYGSTELSA--------YVRGSFSNISKPLA 848
            ..:::..|.|.|.|...:..:.....| |||.:|      |||        .|.|.|....:| |
 Worm   449 TQNLYPTSTSNPSSPSPIMGSAPPTGSILPSANL------LSAEPTTCEPQQVTGRFLKKQRP-A 506

  Fly   849 SLSQSENEDTELNFVKAYQEHSQLMVPIFVNNCIDYLEDNGLQQVGLFRVSTSKKRVKQLREEFD 913
            |.|.|.:.|..::.|..:    .|.||..|.||..||...||.|||||||:.:.||.:|||...:
 Worm   507 SASFSCSLDANIDDVDPH----ALQVPKIVENCTQYLMTYGLTQVGLFRVAGNTKRCRQLRNALE 567

  Fly   914 K-----DIYFGISVDTCPHDVATLLKEFLRDLPEPLLCNTLYLTFLKTQRIRNRRLQLEAISHLI 973
            |     .|...:..:|..|||||||||:.||||:.||....|..::...:: |...::|||..|.
 Worm   568 KVGGGAVINDNMVENTTSHDVATLLKEYFRDLPQSLLPGEHYSAYIGAAKL-NVDERIEAIRLLF 631

  Fly   974 RLLPIPHRDTLYVLLVFLAKVAAHSDDIWSTEGCCLTLGNKMDSYNLATVFAPNILRSTHLTFSR 1038
            .||..|..|||:|||.||.:|:.||.|....:|..|: |||||:.||||:|||:|||..|
 Worm   632 ALLVSPILDTLFVLLKFLHEVSCHSQDRHDEDGELLS-GNKMDARNLATIFAPSILRVDH----- 690

  Fly  1039 DKEQENMID---AINVVRTMINHYEEIFNISAELLNVIYTQALEACPEKLYELISTKVYGTEWTQ 1100
            ||..|.:.:   .:.:|.|||::.||||.|..||...|||:..|..|::|..:::      ..::
 Worm   691 DKLHETLAENEHQVIIVETMISNVEEIFKIPKELQCKIYTKLRETEPDRLDRILN------HLSK 749

  Fly  1101 QQIDDPQPGSLSDVLLEP-PI-----HGKRYENINDFNNINFKRCQDKRRDHSDPDKKKNNNENL 1159
            ....:..||    |||.| |.     ...|:....|.::|.  |.....|:.:...|.|..::.
 Worm   750 MDSHESHPG----VLLSPFPATLEEDSSPRHHRHGDHSHIG--RQSPLARELTTNGKVKVQSQR- 807

  Fly  1160 EIITASLKISVAE-QSHISLKE-----PIKEQE-PITSYKQFSRSTLPTSISDVGVNTLRTDGAK 1217
               :.|...|:.: |:..|..|     |...|: |..|:.....||..|::|   ..|....|.|
 Worm   808 ---SGSWPFSLTKTQTSPSRPEGQHFFPADSQDGPGPSHSHHDPSTSGTTMS---ATTTPGPGRK 866

  Fly  1218 LENKMK 1223
            .:..||
 Worm   867 TDFSMK 872

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP102A	NP_001245416.1	RhoGAP	874..1069	CDD:470621	90/202 (45%)
rga-6	NP_491465.2	RhoGAP_ARHGAP6	520..724	CDD:239841	92/214 (43%)