DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP102A and arhgap6

DIOPT Version :9

Sequence 1:	NP_001245416.1	Gene:	RhoGAP102A / 43781	FlyBaseID:	FBgn0259216	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_001106502.2	Gene:	arhgap6 / 100127692	XenbaseID:	XB-GENE-976843	Length:	800	Species:	Xenopus tropicalis

Alignment Length:	596	Identity:	170/596 - (28%)
Similarity:	261/596 - (43%)	Gaps:	127/596 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   684 FLWISESGESFQIVETNLTRLSKIESDIVKNFALEKIQELNIGNIEDLKISPQKRRCVPK----- 743
            |.|.|.||.|.::....:..||::|...::..|..::|       :|..::.|  ..:||
Frog    17 FTWKSMSGRSVRLKSVPIQSLSELERARLQEVAFYRLQ-------QDYDLNCQ--ITIPKDGQKR 72

  Fly   744 KKSLTTSFFDNGKKDDQN----------PRSVLFGTSLECCLERDSKRNVTMEDRSKYSLLSMFR 798
            ||||.......||:.:::          |.|.:........|.:||:|. ..:|...:....:..
Frog    73 KKSLRKKLDSLGKEKNKDKEFLPQAFGMPLSQVIANDRAHKLRQDSQRE-EQKDAVDFVASILPF 136

  Fly   799 GSGSTPGSVLKLNDNVRSCESLPSKSLEYGSTELS--AYVRGSFS------------------NI 843
            ||......:...|.::.|....|::|....:.|.:  |..||:.|                  .:
Frog   137 GSKRQNKELSSSNSSLSSTSETPNESTSPNTPEAAPRARRRGAMSVDSITDLDDNQSRLLEALQL 201

  Fly   844 SKPLASLSQSENE-DTELNFVKAYQEHSQLMVPIFVNNCIDYLED-----NGLQQVGLFRVSTSK 902
            |.|..:.|:.|.| |.:|:....|::     ||..|::|..:||.     .|||.||:|||.:||
Frog   202 SLPAETQSKKEKERDKKLSLNPIYRQ-----VPRLVDSCCLHLEKYVIFFTGLQTVGIFRVGSSK 261

  Fly   903 KRVKQLREEFDKDIYFGISVDTCPHDVATLLKEFLRDLPEPLLCNTLYLTFLKTQRIRNRRLQLE 967
            |||:|||||||:.|...:..:...||:|.||||||||:|:|||...||..|:.| .:.:...||.
Frog   262 KRVRQLREEFDRGIDVALDEEHSVHDIAALLKEFLRDMPDPLLTRELYTAFINT-LLLDTDDQLC 325

  Fly   968 AISHLIRLLPIPHRDTLYVLLVFLAKVAAHSDDIWSTEGCCLTLGNKMDSYNLATVFAPNILRST 1032
            .:..||.|||..:.|||:.||.||:.||.|:||....:|..:| ||||.|.||||:|.||:|
Frog   326 TLQLLIYLLPPCNCDTLHRLLQFLSTVANHADDTMDKDGQEIT-GNKMTSLNLATIFGPNLL--- 386

  Fly  1033 HLTFSRDKE---------QENMIDAINVVRTMINHYEEIFNISAELLNVIYTQALEACPEKLYEL 1088
            |...|.|||         :|:.| .|.:|:.||.::|.:|.:..:|.|.:....||..|:.:..|
Frog   387 HKQKSSDKEFTVQSTARAEESTI-IIAIVQKMIENFESLFMVPPDLQNEVLISLLETDPDVVDYL 450

  Fly  1089 ISTKV--------------------YGTEWTQQQIDDPQP-GSLSDVLLEPPIHGKRYENINDFN 1132
            :..|.                    ..|:..:....|..| .:.|.||.|..| .::.:::|
Frog   451 LRRKASQSSSPELLRSESSFSEGRHSSTDSNKASSGDVSPYDNNSPVLSERAI-SRQEDSVN--- 511

  Fly  1133 NINFKRCQDKRRDHSDPD----------KKKNNNENLEIITASLKISVAEQS-------HISLKE 1180
                     ..:.|..|:          |.|:::.     |......|.|.:       |.:||.
Frog   512 ---------SEKLHKVPEPHTLVGHLLSKTKDSSS-----TQWCNKEVPEDNFNIWGTWHSTLKS 562

  Fly  1181 PIKEQEPITSY 1191
            ..|:|....||
Frog   563 TCKDQGMTDSY 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP102A	NP_001245416.1	RhoGAP	874..1069	CDD:295372	93/208 (45%)
arhgap6	NP_001106502.2	RhoGAP_ARHGAP6	220..431	CDD:239841	94/221 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	139	1.000	Domainoid score	I4756
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006356
OrthoInspector	1	1.000	-	-		otm49321
Panther	1	1.100	-	-	LDO	PTHR12635
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3427
SonicParanoid	1	1.000	-	-		X6395
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.130