DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1674 and SYNPO2L

DIOPT Version :9

Sequence 1:	NP_001245414.1	Gene:	CG1674 / 43780	FlyBaseID:	FBgn0039897	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	NP_001107605.1	Gene:	SYNPO2L / 79933	HGNCID:	23532	Length:	977	Species:	Homo sapiens

Alignment Length:	361	Identity:	80/361 - (22%)
Similarity:	133/361 - (36%)	Gaps:	110/361 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   271 PTLHPTVED----------QVEL-----------------ARRISHSLSDISNQTSKGQSMYVNR 308
            |..||..||          |.:|                 .|.|:..|:...|..|||..|:..|
Human   237 PVPHPVAEDLTTTYTQKAKQAKLQRAESLQEKSIKEAKTKCRTIASLLTAAPNPHSKGVLMFKKR 301

  Fly   309 KKRSDKW--VHEG-----GSQGNDAINPFKENSETKSTMEVAKLEKIPLKLIMNPNGKVRDYNS- 365
            ::|:.|:  |..|     |::..|.:.|..|:...:.....|       :.:.|.:    |::|
Human   302 RQRAKKYTLVSFGAAAGTGAEEEDGVPPTSESELDEEAFSDA-------RSLTNQS----DWDSP 355

  Fly   366 LKDLINVEAGLLSPDNCAELITALQLHQ--GRGAELFAKRRRKADNWVVDESHSGTQ----YHPS 424
            ..|:....||..:.:.....:.. ||.:  |||.:||.::|::||        |.||    ..|:
Human   356 YLDMELARAGSRASEGQGSGLGG-QLSEVSGRGVQLFEQQRQRAD--------SSTQELARVEPA 411

  Fly   425 GIPDFQQYQQRP----------VLSPNILPA-------YSDAGKHRVQLNIHQNQLIEKYSKPGL 472
            .:.:.:..|..|          ||.|:.|||       :...|..........|:....:: |||
Human   412 AMLNGEGLQSPPRAQSAPPEAAVLPPSPLPAPVASPRPFQPGGGAPTPAPSIFNRSARPFT-PGL 475

  Fly   473 QVVQ-----------SPWKAALQTGSASSAFLEDTKSFSPPAL-----TPIPSSQAGSKDWTDAN 521
            |..:           :|.:|....|..|.|        .||.|     ||:||..:|    ..::
Human   476 QGQRPTTTSVIFRPLAPKRANDSLGGLSPA--------PPPFLSSQGPTPLPSFTSG----VPSH 528

  Fly   522 EPMPHGSSRRNTNAVASSPRSVIVPSNPQRDLAYTP 557
            .|:....|...::...::..|:.:|: |.|.:  ||
Human   529 APVSGSPSTPRSSGPVTATSSLYIPA-PSRPV--TP 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1674	NP_001245414.1	None
SYNPO2L	NP_001107605.1	PDZ_signaling	6..85	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	91..226
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..352		6/45 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..677		51/223 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	697..802
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	922..950
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147925
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24217
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030