DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1674 and synpo2la

DIOPT Version :9

Sequence 1:	NP_001245414.1	Gene:	CG1674 / 43780	FlyBaseID:	FBgn0039897	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	XP_009305650.2	Gene:	synpo2la / 563843	ZFINID:	ZDB-GENE-090828-4	Length:	1179	Species:	Danio rerio

Alignment Length:	844	Identity:	161/844 - (19%)
Similarity:	264/844 - (31%)	Gaps:	284/844 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 LHSQYQNERGGPTSTLYQEKNIASKQIPVVHNNMNCTVEKKRGYR-PSD---LIDPSKRQYLLSL 222
            ||..:.::....||::..:.          .|.....:|:..|:: |::   |:.|.:.:..|.|
Zfish   235 LHGAWSSQTSTETSSMSADD----------QNPREGLMEEDSGFQEPTNIPPLVSPERAKEALML 289

  Fly   223 SKKLWQEKKESANVSKTVDLRKIFTPATDAAEILPKNRKLYASSAFYSPTLHPTVED-QVELA-- 284
            |.:. |.......|...|| .::.....|.|:....||             ..|:.| ||:.|
Zfish   290 SSRS-QLVPMVGPVDNPVD-EELTLTYMDKAKQAKLNR-------------GETITDKQVKEARS 339

  Fly   285 --RRISHSLSDISNQTSKGQSMYVNRKKRSDKW-------VHEG---GSQGNDAINPFKENSETK 337
              |.|:..|:|..|..|||..|:..|::||.|:       |.|.   .||..|.|.|..|:...:
Zfish   340 KCRTIASLLTDAPNPHSKGVLMFKKRRQRSKKYTLTSFGSVDEDMRQDSQEEDGIFPGSESEFDE 404

  Fly   338 STMEVAK--------LEKIPLKLIMNPNGKVRDYNSLKDLINVEAGLLSPDNCAELITALQLHQG 394
            .....|.        ||.:..:..  ..|:..|           .|.|||        .|....|
Zfish   405 EGFSAAPDPTWDSDYLEMLEKRCA--SRGQEGD-----------GGALSP--------GLSDTSG 448

  Fly   395 RGAELFAKRRRKADNWV--VDESHSGTQYHPSGI--------PDFQQYQQRPVLSPNILP----- 444
            :||:||.::|::|:...  ::.:....|....||        |..|.....|:...|:.|
Zfish   449 KGAQLFEQQRKRAEEHARKIEAAQEQLQSQMLGISLKEAQALPPLQTAHPDPLTKLNVQPPPVAP 513

  Fly   445 --------AYSD-----AGKHRVQLNIHQNQLIEKYSKPGLQVVQSPWKAALQTGSASSAFLE-- 494
                    .|.|     |..::.|:|..|.               .|....:..|.||:..:.
Zfish   514 KPARPSTTLYHDVQAAEAQNNKTQMNTPQT---------------IPTVPVMVNGDASNTTVTAP 563

  Fly   495 -----------DTKSFSPPALTPIPSSQAGSKDWTDANEPMPHGSSRRNTNAVASSP-------- 540
                       .|::..||..||:|...|.|. ......|...|..   ||..|::|
Zfish   564 SVMPKTNLSVLSTETVMPPPPTPLPELPASSV-LNRTARPFAPGCI---TNRAATAPVVFRPAVS 624

  Fly   541 --------RSVIVPSNPQRDLAYTPCVAQGWGGRSVELPKDSFQSNESQSSWQTEPHIGRADDSN 597
                    .:|:.|..|.....:..||.....|..|.:  ....:|.|.....|:|
Zfish   625 KKTPRPVSVAVVAPPFPAASEEHVMCVTPAIFGTQVTM--SQMNANVSNEIIPTQP--------- 678

  Fly   598 PSFNNYIFGERLTSNFAFDVQNRLHSLENFQKYFLEYQRLELEILRNRESSRVLQHDAYESLLDF 662
                 ...|..:....|..|::  :|...||             ....||.:|......::....
Zfish   679 -----LAQGTSIPPPAAVSVES--YSQSAFQ-------------CSPMESIQVASLPRVQAQKPT 723

  Fly   663 TPQNEFKVISGEDLKVNCDLDEKVNVRELIQSFEKQNTTDLRHDAAPIEGLYVPKEISLSSYAAP 727
            .|.....::..:|:..:.                   .||:.           ||.|::||..:
Zfish   724 VPMIAETIVPPDDMVTSL-------------------ATDMH-----------PKGIAISSQTS- 757

  Fly   728 SQQCEIHSKHFERPYEDTFPRTFPRNNYSANNNFPGNDGIGEFPLSKPTGLTTGTLHQQPYSPTS 792
                                                       .:..||...|.:....|.||..
Zfish   758 -------------------------------------------SILTPTASETTSSPVIPLSPVV 779

  Fly   793 YKK---TVPGLEKVENFAR--------YEQPDRKRLTSGSPQYLNALQNSQVR--NASPIPFGTS 844
            |::   :|.|...:...||        ::.||.|: .|.:|:.|..:||...|  :..|.|....
Zfish   780 YREKPASVGGRTGILQDARRRSAYKPMFKMPDSKK-NSPNPELLTMVQNLDDRPSHGYPEPDNIV 843

  Fly   845 LN---EQTSWPPRSVLLQGGSPSPLPNHVQTFNKC--AKGWGS-IPVKQQSYSSQYNLPGNLPY 902
            .|   .:|..||        ..:|.|..:...::.  |:|.|: :..::||...|:.:  :.||
Zfish   844 YNIDENRTRVPP--------PVAPKPRVIPEMSQIPQAEGKGAELFARRQSRMDQFVV--DTPY 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1674	NP_001245414.1	None
synpo2la	XP_009305650.2	PDZ_signaling	5..84	CDD:238492
		TrbI	336..>516	CDD:329122	47/200 (24%)
		Atrophin-1	<491..961	CDD:331285	94/542 (17%)
		DNA_pol3_gamma3	<1014..1178	CDD:331207
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581816
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24217
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.030