DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1674 and Synpo2

DIOPT Version :9

Sequence 1:	NP_001245414.1	Gene:	CG1674 / 43780	FlyBaseID:	FBgn0039897	Length:	905	Species:	Drosophila melanogaster
Sequence 2:	NP_001178892.1	Gene:	Synpo2 / 499702	RGDID:	1564779	Length:	1262	Species:	Rattus norvegicus

Alignment Length:	1128	Identity:	190/1128 - (16%)
Similarity:	361/1128 - (32%)	Gaps:	422/1128 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 NSIPSPIKPNVN------DQTSSASDLTAENTKADHDSLNKPKDFNNQILNIISDIDINIKAQEK 112
            ||||:|.|.:.:      .||||..:||....: |......|:      :.:|.|..
  Rat   236 NSIPAPEKADTSLTSGTTVQTSSGRELTVIQGR-DPGGTGLPQ------VEVILDCS-------- 285

  Fly   113 ITQLKEQELKLIQKQNDLANEIH------KQQILAKQLSAQNQLKQNECQSGELDLHSQYQNERG 171
             .:||.:|.:|...:..:|:.:.      ...:::..:|::...:..:.:||:         ::|
  Rat   286 -DRLKAEECRLQAGRGCVASPVEGGRSEAPPSLVSFAVSSEGTEQGEDQRSGK---------DQG 340

  Fly   172 GP------TSTLYQEKNIASKQIPVVH----------------NNMNCTVEKKRGYRPSDLIDPS 214
            .|      .:.|.:.::::.||:....                |:....:.|||..|
  Rat   341 RPHKHRARHARLRRSESLSEKQVKEAKSKCKSIALLLTDAPNPNSKGVLMFKKRRRR-------- 397

  Fly   215 KRQYLL------SLSKKLWQEKKESANVSKTVDLRKIFTPATDAAEILPKNRKLYASSAFYSPTL 273
            .|:|.|      .|.::..:|.:|:.:..:..||..:.|..::..|.|..:
  Rat   398 ARKYTLVSYGTGELEREEEEEDQEAGDKDEISDLAFLGTSESEVDEELLSD-------------- 448

  Fly   274 HPTVEDQ------------VELARRISH--SLSDISNQTSKGQSMYVNRKKRSDKWVHE------ 318
               |:|.            |::.:|::.  .:..:.:.|.||..|:..|::|.:::..:
  Rat   449 ---VDDNTQVVNFDWDSGLVDIEKRLNRGDKMEMLPDTTGKGALMFAKRRERMEQFTAQNEEEKT 510

  Fly   319 GG--SQGNDAINPFKENSETKSTMEVAKLEKIPLKLIMNPN--------GKVRDYNSLKDLINVE 373
            ||  ..|:||:.  .:...|.::.: .|.|.:.::..::.:        |.|...|....
  Rat   511 GGLAGGGSDALQ--TDGLRTMTSYQ-RKEESVRMQSSVSESSFQMGRSLGSVPQQNGFSG----- 567

  Fly   374 AGLLSPDNCAELITALQLHQGRGAELFAKRRRKADNWVVDESHSGTQYHP-----SGIPDF---- 429
                             :.:..|.:......|.|..::...:.:...:.|     |.||||
  Rat   568 -----------------VSETAGPQRMIPMNRTAKPFLGSVNQTAAPFSPTQSVTSPIPDFPAPP 615

  Fly   430 -----------------------QQYQQRPVLSPNILPAYSDAGK------HRVQLNIHQNQLIE 465
                                   .|....|..:|...||:.|:.:      .|:.:...:..:::
  Rat   616 PYSAVSPPPEAFSRGISSPVAGPAQPPPWPQPAPWSQPAFYDSSEQIASRDERIAVPAKRTGILQ 680

  Fly   466 KYSKPG-------------------LQVVQS--------------PWKAALQTGSASSAFLEDT- 496
            :..:.|                   |.::|:              |.:..|..|:.:..|::.:
  Rat   681 EAKRRGTTKPMFTFKETKVSPNPELLSLLQNAEGKRGTGAGGDSGPEEDYLSLGAEACNFMQSSA 745

  Fly   497 KSFSPPALTPIPSSQAGSKD---------WTDANEPMPHGSSRRNTN--------AVAS------ 538
            |..:||.:.|.|:.:..|..         |:....| ..|.:...||        ||:|
  Rat   746 KQKTPPPVAPKPAVKTSSSSQPVAPVSPVWSPGVAP-AQGPAFSTTNPPNPPQVTAVSSIKIAQP 809

  Fly   539 ------------------SPRSVIVPSNPQRDLAYTP----------CVAQGWGGRSVELPKDS- 574
                              .|::.:|..|      |||          ....|.||.|.|||..|
  Rat   810 TCPPARPASALNLAGPFKGPQAAVVSHN------YTPKPSAPTPLVNAAPAGAGGPSNELPGMSG 868

  Fly   575 -----FQSNESQ------SSWQTEPHIGRADDSNPSFN---NYIFGERLTSNFAFDVQNRLHSLE 625
                 |...:|:      .|...:.|..||....||..   .|....|.....|:   |.:||
  Rat   869 KGAQLFAKRQSRMEKYVVDSDTVQAHTVRAQSPTPSLPASWKYSSNVRAPPPVAY---NPIHS-- 928

  Fly   626 NFQKYFLEYQRLELEILRNR----ESSRVLQHDAYESLLDFTPQNEFKVISGEDLKVNCDLDEKV 686
                     ....|..::::    ::|:..:....:      |.|...|:..:..::|..|
  Rat   929 ---------PSYPLAAIKSQPPGAQASKTSKKKGKK------PLNTLDVMKHQPYQLNASL---- 974

  Fly   687 NVRELIQSFEKQNTTDLRHDAAPIEGLYVPKEISLSS------YAAPSQQCEIHSKHFERPYEDT 745
                  .:|:..::.|         ||.....:.:||      .|.|.:|.:|.|     |....
  Rat   975 ------FTFQPPDSKD---------GLPQKSTVKVSSVAPAMKQALPPRQADIGS-----PTNAK 1019

  Fly   746 FPRTFPRNNYSANNNFPGNDGIGEFPLS-KPTGLTTGTLHQQPYSPTSY----------KKTVPG 799
            ....:....|::..||...   ...|:| .|..::..|..:|..:.|||          ||:  |
  Rat  1020 ASSVYSVPAYTSQPNFFAE---ATSPVSASPVPVSVPTSPKQETTSTSYFVAPRPKFSAKKS--G 1079

  Fly   800 LEKVENFARYEQPDRKRLTSGSPQYLNA----LQNSQVRNASPIPFGTSLNEQ-TSWPPRSVLLQ 859
            :...||:.....|.|     .:|..::|    .|.:...::.|.......|:: |.|       :
  Rat  1080 VTVQENWRSLSLPGR-----AAPPIMSAPPWLCQPAYSYSSKPTLEQEKANKRPTPW-------E 1132

  Fly   860 GGSPSPL--------PNHVQ--------------TFNKCAKGW----GSIPVKQQSYSS-----Q 893
            ..:.|||        |.:::              .|....:.|    ..:|..|::..|     :
  Rat  1133 AAAKSPLGLVDEAFRPRNIEESIVANVVSAARRKVFAGSQEDWKERLSFVPQTQKTSMSFSERRE 1197

  Fly   894 YNLP--------------GNLPY 902
            ||:|              ..|||
  Rat  1198 YNVPSPVNSHVSSHSLYSSQLPY 1220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1674	NP_001245414.1	None
Synpo2	NP_001178892.1	Interaction with VPS18. /evidence=ECO:0000250\|UniProtKB:Q9UMS6	1..174
		PDZ_signaling	7..85	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..114
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	239..276		10/37 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	323..363		7/48 (15%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q91YE8	392..400		4/15 (27%)
		Interaction with ACTN2. /evidence=ECO:0000250\|UniProtKB:Q9UMS6	477..658		31/205 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	503..576		12/97 (12%)
		F-actin binding. /evidence=ECO:0000250\|UniProtKB:Q9UMS6	530..658		19/150 (13%)
		Interaction with YWHAB. /evidence=ECO:0000250\|UniProtKB:Q91YE8	554..560		1/5 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	592..703		14/110 (13%)
		Interaction with YWHAB. /evidence=ECO:0000250\|UniProtKB:Q91YE8	602..809		33/207 (16%)
		Interaction with BAG3. /evidence=ECO:0000250\|UniProtKB:Q9UMS6	610..621		2/10 (20%)
		PPPY motif. /evidence=ECO:0000250\|UniProtKB:Q9UMS6	614..617		0/2 (0%)
		Atrophin-1	<651..1101	CDD:331285	91/510 (18%)
		Interaction with ACTN2. /evidence=ECO:0000250\|UniProtKB:Q9UMS6	659..922		46/269 (17%)
		F-actin bundling activity. /evidence=ECO:0000250\|UniProtKB:Q9UMS6	659..914		45/261 (17%)
		F-actin binding. /evidence=ECO:0000250\|UniProtKB:Q9UMS6	659..801		19/142 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	741..799		11/58 (19%)
		Actin binding. /evidence=ECO:0000250\|UniProtKB:Q91YE8	745..898		32/159 (20%)
		Interaction with FLNC. /evidence=ECO:0000250\|UniProtKB:Q9UMS6	808..1153		76/411 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	833..868		12/40 (30%)
		Interaction with ACTN2. /evidence=ECO:0000250\|UniProtKB:Q9UMS6	899..1153		56/314 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	933..957		2/29 (7%)
		Interaction with ZYX. /evidence=ECO:0000250\|UniProtKB:Q9UMS6	999..1018		6/23 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341795
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24217
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030