DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG1674 and SYNPO2

DIOPT Version :9

Sequence 1:NP_001245414.1 Gene:CG1674 / 43780 FlyBaseID:FBgn0039897 Length:905 Species:Drosophila melanogaster
Sequence 2:NP_597734.2 Gene:SYNPO2 / 171024 HGNCID:17732 Length:1261 Species:Homo sapiens


Alignment Length:1007 Identity:200/1007 - (19%)
Similarity:344/1007 - (34%) Gaps:263/1007 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 IENVND--------PTS-IASDLSAENTKADLVSLNEPKTYEPTT--IAPDLKMENTKNSIPSPI 60
            :|::.|        |:| |:..|.:||...:|..|......|.||  |.|..|.:.|:..: :|:
Human    73 MESITDSLQMLIKRPSSGISEALISENENKNLEHLTHGGYVESTTLQIRPATKTQCTEFFL-APV 136

  Fly    61 KPNVNDQTSSASDLTAENTKADHD---SLNKPKDFNNQILNIISDIDINIKAQEKITQLKEQELK 122
            |..|.         .|||.::..|   ||.:....:.|....:.|......|:|.|.:.|.:.::
Human   137 KTEVP---------LAENQRSGPDCAGSLKEETGPSYQRAPQMPDSQRGRVAEELILREKVEAVQ 192

  Fly   123 ---LIQKQNDLANEIHK------QQILAKQLSAQNQLKQNECQSGELDLHSQYQNERGGP----- 173
               :::.|..|:.|.||      ..:...:.|.......|......:.::|...||:..|     
Human   193 PGPVVELQLSLSQERHKGASGPLVALPGAEKSKSPDPDPNLSHDRIVHINSIPTNEKADPFLRSS 257

  Fly   174 ---------TSTLYQEKNIASKQIPVVHNNMNCT-VEKKRGYR---PSDLID-----------PS 214
                     ...:.||.......:|.|...::|: .:|..|.|   ..:.:|           ||
Human   258 KIIQISSGRELRVIQESEAGDAGLPRVEVILDCSDRQKTEGCRLQAGKECVDSPVEGGQSEAPPS 322

  Fly   215 KRQYLLSLSKKLWQEKKESANVSKTVDLRKIFTPATDAAEILP-KNRKLYASSAFYSPTLHPTVE 278
            ...:.:|      .|..|...           .|.::.....| |:|..:|............|:
Human   323 LVSFAVS------SEGTEQGE-----------DPRSEKDHSRPHKHRARHARLRRSESLSEKQVK 370

  Fly   279 DQVELARRISHSLSDISNQTSKGQSMYVNRKKRSDKWV---HEGGSQGNDAINPFKENSETKSTM 340
            :.....:.|:..|:|..|..|||..|:..|::|:.|:.   :..|....:|..  :|..:.:.|.
Human   371 EAKSKCKSIALLLTDAPNPNSKGVLMFKKRRRRARKYTLVSYGTGELEREADE--EEEGDKEDTC 433

  Fly   341 EVAKL----EKIPLKLI--MNPNGKVRDYNSLKDLINVEAGLLSPDNCAELITALQLHQGRGAEL 399
            |||.|    .::..:|:  ::.|.:|.:::....|:::|..|    |..:.:..|....|:||.:
Human   434 EVAFLGASESEVDEELLSDVDDNTQVVNFDWDSGLVDIEKKL----NRGDKMEMLPDTTGKGALM 494

  Fly   400 FAKRRRKADNWVVDESHSGTQYHPS---------GIPDFQQYQQRPVLSPNILPAYSDAGKHRVQ 455
            |||||.:.|.....:........||         |:.....||::            :....|.|
Human   495 FAKRRERMDQITAQKEEDKVGGTPSREQDAAQTDGLRTTTSYQRK------------EEESVRTQ 547

  Fly   456 LNIHQNQLIEKYSKPGLQVVQSPWKAALQTGSASSAFLEDTKSFSPPALT--PIPSSQAGSKDWT 518
            .::         ||..::|.........|.|.:.::...:.:...|...|  |.|.|        
Human   548 SSV---------SKSYIEVSHGLGHVPQQNGFSGTSETANIQRMVPMNRTAKPFPGS-------- 595

  Fly   519 DANEP-MPHGSSRRNTNAVASSPRSVIVPSNPQRDLAYTPCVAQGWGGRSVELPKDSFQ---SNE 579
             .|:| .|...:|..|:.:|..|.       |....|.||             |.|:|.   |:.
Human   596 -VNQPATPFSPTRNMTSPIADFPA-------PPPYSAVTP-------------PPDAFSRGVSSP 639

  Fly   580 SQSSWQTEPHIGRADDSNPSFNNYIFGERLTSNFAFDVQNRLHSLENFQKYFLEYQRLELEILRN 644
            .....|..|....|..|.|:|              :|...|:.|.:         :|:.:...| 
Human   640 IAGPAQPPPWPQPAPWSQPAF--------------YDSSERIASRD---------ERISVPAKR- 680

  Fly   645 RESSRVLQHDAYESLLDFTPQNEFKVISGEDLKVNCDLDEKVN----VRELIQSFEKQNTTDLRH 705
               :.:||.....|..  .|...||             :.||:    :..|:|:.|.:..|....
Human   681 ---TGILQEAKRRSTT--KPMFTFK-------------EPKVSPNPELLSLLQNSEGKRGTGAGG 727

  Fly   706 DAAPIEGLYVPKEISLSSYAAPSQQCEIHSKHFERPYEDTFPRTFPRNNYSANNNFP-------G 763
            |:.|.|..     :||.:.|....|.       ....:.|.|...|:....::::.|       .
Human   728 DSGPEEDY-----LSLGAEACNFMQS-------SSAKQKTPPPVAPKPAVKSSSSQPVTPVSPVW 780

  Fly   764 NDGIG-----EFPLSKP---TGLTTGTLHQQPYSPTSYKKT--VPGLEKVENFARYEQPDRKRLT 818
            :.|:.     .||.|.|   |.:::..:.|..|.|.....|  |.|..|....|...|....:.|
Human   781 SPGVAPTQPPAFPTSNPSKGTVVSSIKIAQPSYPPARPASTLNVAGPFKGPQAAVASQNYTPKPT 845

  Fly   819 SGSPQYLNALQNSQVRNASPIP---------FGTSLNEQTSWPPRSVLLQ---GGSPSPLPNHVQ 871
            ..:|. :||:|...|..::.:|         |....:....:...|..:|   ..:.||.|    
Human   846 VSTPT-VNAVQPGAVGPSNELPGMSGRGAQLFAKRQSRMEKYVVDSDTVQAHAARAQSPTP---- 905

  Fly   872 TFNKCAKGWGSIPVKQQSYSSQYNLPGNLPYS 903
                      |:|...: |||....|..:.|:
Human   906 ----------SLPASWK-YSSNVRAPPPVAYN 926

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1674NP_001245414.1 None
SYNPO2NP_597734.2 Interaction with VPS18. /evidence=ECO:0000269|PubMed:23434281 1..180 28/116 (24%)
PDZ_signaling 7..85 CDD:238492 2/11 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 144..174 7/29 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 211..233 1/21 (5%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 329..369 8/56 (14%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q91YE8 398..406 2/7 (29%)
Interaction with ACTN2. /evidence=ECO:0000269|PubMed:20554076 481..663 48/245 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 507..803 72/399 (18%)
F-actin binding. /evidence=ECO:0000269|PubMed:23225103 534..663 35/192 (18%)
Interaction with YWHAB. /evidence=ECO:0000250|UniProtKB:Q91YE8 607..811 52/277 (19%)
Interaction with BAG3. /evidence=ECO:0000269|PubMed:23434281 615..626 3/17 (18%)
PPPY motif. /evidence=ECO:0000305|PubMed:23434281 619..622 1/2 (50%)
Interaction with ACTN2. /evidence=ECO:0000269|PubMed:20554076 664..924 61/315 (19%)
F-actin bundling activity. /evidence=ECO:0000269|PubMed:23225103 664..916 59/307 (19%)
F-actin binding. /evidence=ECO:0000269|PubMed:23225103 664..803 33/178 (19%)
Actin binding. /evidence=ECO:0000250|UniProtKB:Q91YE8 751..900 29/149 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 834..870 9/36 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 937..956
Interaction with ZYX. /evidence=ECO:0000269|PubMed:16885336 1000..1019
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1041..1064
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147924
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR24217
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.030

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