Protein Alignment CG1674 and SYNPO

DIOPT Version :10

• Sequence 1: NP_001245414.1
• Gene: CG1674 / 43780
• FlyBaseID: FBgn0039897
• Length: 905
• Species: Drosophila melanogaster
• Sequence 2: XP_006714818.1
• Gene: SYNPO / 11346
• HGNCID: 30672
• Length: 1147
• Species: Homo sapiens
• Alignment Length: 1093
• Identity: 208/1093 - (19%)
• Similarity: 327/1093 - (29%)
• Gaps: 399/1093 - (36%)

  Fly    44 APDLKMENTKNSIPSPIKPNVNDQTSSASDLTAENTKADHDSLNKP-KDFNNQILNIISDIDINI 107
            ||.|.:.:|  |:|.|..|.                   |.|...| :......:...|:....:
Human   212 APGLSLSST--SLPEPGPPR-------------------HPSPQSPDRGVPGHSMEGYSEEASLL 255

  Fly   108 KAQEKITQLKEQELKLI--QKQND---LANEIHKQQILAKQLSAQNQLKQNECQSGELDLHS--- 164
            :..||:.. :|:|:.|:  .|:|.   .||.:|        ||...:.:|:.......::||
Human   256 RHLEKVAS-EEEEVPLVVYLKENAALLTANGLH--------LSQNREAQQSSPAPPPAEVHSPAA 311

  Fly   165 QYQNERGGPTSTLYQEKNIASKQIPVVHNNMN--CTV------------EKKRGYRPSDLIDPSK 215
            ........|::||....:.:|...|....|.|  .||            .......||:...|:.
Human   312 DVNQNLASPSATLTTPTSNSSHNPPATDVNQNPPATVVPQSLPLSSIQQNSSEAQLPSNGTGPAS 376

  Fly   216 RQYLLSLSKKLWQEKKESANVSKTVDLRKIFTPATDAAEILPKNRKLYASSAFYSPTLHPTVEDQ 280
            :...|....:. |...|....| |:.:.|:.||||..:        .::..|...|:..|...|.
Human   377 KPSTLCADGQP-QAPAEEVRCS-TLLIDKVSTPATTTS--------TFSREATLIPSSRPPASDF 431

  Fly   281 VELARRISHSLSDISNQT---SKGQSMYVNRKKRSDKWVHEGGSQGNDAINPFKENSETKSTMEV 342
            :.     |..|.||...|   |..|.|                |....|..|.|..||...|:
Human   432 MS-----SSLLIDIQPNTLVVSADQEM----------------SGRAAATTPTKVYSEVHFTL-- 473

  Fly   343 AKLEKIPLKLIMNPNGKVRDYNSLKDLINVEAGLLSPDNCAELITALQLHQGRGAELFAKRRRKA 407
            ||    |..::   |...|.:           |:.:|...:::..:..|          :||
Human   474 AK----PPSVV---NRTARPF-----------GIQAPGGTSQMERSPML----------ERR--- 507

  Fly   408 DNWVVDESHSGTQY---HPSGIPDFQQYQQR------PVLSPNILPAYSDAGKHRVQLNIHQNQL 463
                    |.|.:.   .|..:||.....||      |::...::...|.|.:.|.
Human   508 --------HFGEKAPAPQPPSLPDRSPRPQRHIMSRSPMVERRMMGQRSPASERRP--------- 555

  Fly   464 IEKYSKPGLQVVQSPWKAALQTGSASSAFLEDTKSFSP--PALTP---------IPSSQAGSKDW 517
            :..::.|      ..:...|.|...:| ::....|:|.  |:..|         :|:|:.|..:
Human   556 LGNFTAP------PTYTETLSTAPLAS-WVRSPPSYSVLYPSSDPKSSHLKGQAVPASKTGILE- 612

  Fly   518 TDANEPMPHGSSRRNTNAVASSPRSVIVPSNP--------------QRDLAYTPCVAQGWGGRSV 568
                |.|....||::.......|:   |..||              |||        ||    .|
Human   613 ----ESMARRGSRKSMFTFVEKPK---VTPNPDLLDLVQTADEKRRQRD--------QG----EV 658

  Fly   569 ELPKDSFQSNESQSSWQTEP------HIGRADDSNPSFNNYIFGERL--------------TSNF 613
            .:.::.|......|::|.||      ....|::..|.:.:.:...|:              .|..
Human   659 GVEEEPFALGAEASNFQQEPAPRDRASPAAAEEVVPEWASCLKSPRIQAKPKPKPNQNLSEASGK 723

  Fly   614 AFDVQNRLHSLENFQKYFLEYQRLELEILR-------------------------NRESSRVLQH 653
            ..::..|..|  ..:||.:|......|:.|                         :|..:|....
Human   724 GAELYARRQS--RMEKYVIESSSHTPELARCPSPTMSLPSSWKYPTNAPGAFRVASRSPARTPPA 786

  Fly   654 DAYESLLDFTPQNEFKVISGEDLK-----------VNCDLDEKVNVRELIQSFEKQNTTDL---- 703
            ..|...|   |:|  .|:..|..|           |...:.|...|.....|..|.::.||
Human   787 SLYHGYL---PEN--GVLRPEPTKQPPYQLRPSLFVLSPIKEPAKVSPRAASPAKPSSLDLVPNL 846

  Fly   704 -RHDAAPIEGLYVPKEISLSSYAAPSQQCEIHSKHFERPY-EDTFP-----------RTFPRNNY 755
             :....|...|..|...|...|.:|.|. .:.......|| .|..|           :..||.::
Human   847 PKGALPPSPALPRPSRSSPGLYTSPGQD-SLQPTAVSPPYGGDISPVSPSRAWSPRAKQAPRPSF 910

  Fly   756 SANN-NFPGNDGIGEFPLSKPTGLTTGTLH------------------------------QQPYS 789
            |..| .....|.....|.|.|  .|.|...                              ..|.|
Human   911 STRNAGIEAQDRRESLPTSPP--WTPGASRPPSSLDGWVSPGPWEPGRGSSMSSPPPLPPPPPMS 973

  Fly   790 PTSYKKTVPGLEKVENFARYEQPDRK-------------RLTSGSPQYLNA-------------- 827
            |:..:::|..| :.|..||  .|.|:             |..|.||:...|
Human   974 PSWSERSVSPL-RPETEAR--PPSRQLQALLARNIINAARRKSASPRSAGAENPRPFSPPRAPPP 1035

  Fly   828 ----------LQNSQ--------VRNA-------SPIPFG----TSLNEQTSWPPRSVLLQ---- 859
                      :::.|        |..|       ||:|.|    ||.......|||..|.:
Human  1036 PPPPPPPPPRMRSPQPARPGSAAVPGAAFAPIPRSPLPAGPSSCTSPRSPLPAPPRPFLYRRSPT 1100

  Fly   860 ----------GGSPSPLPNHVQTFNKCAKGW-GSIPVKQQSYSSQYNLPGNLP 901
                      .|:.||   .:..:|.|.:|| ||:.:|:          |:||
Human  1101 DSDVSLDSEDSGAKSP---GILGYNICPRGWNGSLRLKR----------GSLP 1140

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1674	NP_001245414.1	None
SYNPO	XP_006714818.1	PHA03247	<180..611	CDD:223021	100/516 (19%)
		PRK13914	<259..>386	CDD:237555	28/135 (21%)
		PHA03247	<743..1144	CDD:223021	80/422 (19%)