DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31999 and FBN3

DIOPT Version :9

Sequence 1:	NP_001284712.1	Gene:	CG31999 / 43777	FlyBaseID:	FBgn0051999	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	XP_016882868.1	Gene:	FBN3 / 84467	HGNCID:	18794	Length:	2851	Species:	Homo sapiens

Alignment Length:	1041	Identity:	268/1041 - (25%)
Similarity:	368/1041 - (35%)	Gaps:	378/1041 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SISGYIRKCCINGLRHARTTASCKKIDIAPTIIPQLWLGLCHSTLEVCCSRE------------- 77
            :|.|.....|..|.:...|..:|  :|:...|:..   ||||  |..|.:.|
Human   507 NIPGTYHCRCYPGFQATPTRQAC--VDVDECIVSG---GLCH--LGRCVNTEGSFQCVCNAGFEL 564

  Fly    78 -------LDHQD----------------------CELGRLAALDGTRCDG-----------EGNV 102
                   :||.:                      |:.|.|.|..|..|..           .|:.
Human   565 SPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKPGFLLAPGGHYCMDIDECQTPGICVNGHC 629

  Fly   103 TSSSYATCCRSCQIGLAVKASKANCKDPLFSFIFLIESYRACCYGSAD----FKDQPGI---DEI 160
            |::..:..|: |..||||......|.|         ...|:.|||:.:    .:..||.   .|.
Human   630 TNTEGSFRCQ-CLGGLAVGTDGRVCVD---------THVRSTCYGAIEKGSCARPFPGTVTKSEC 684

  Fly   161 DKAN------------SITDEGELPFVSEEDMNVTIVLTGDDDI--CGKIENLCAH-ICENTFDA 210
            ..||            ...|..|...:....:.:|   |...||  |.....:||: :|||...:
Human   685 CCANPDHGFGEPCQLCPAKDSAEFQALCSSGLGIT---TDGRDINECALDPEVCANGVCENLRGS 746

  Fly   211 YQCKCHPGFMLDNNNVTCSPMKTQICPSGYNLDKLDNKCIDIDECREDLHDCKSSQYCHNTNGGY 275
            |:|                     :|..||........|.|:|||..:...|.:. :|.|:.|.|
Human   747 YRC---------------------VCNLGYEAGASGKDCTDVDECALNSLLCDNG-WCQNSPGSY 789

  Fly   276 HCLNVKEKECPPGFHYDHDYDACKDDYKCKDRKCVKIQSCDKGFSLHNGTCSDIDECSHKSLNNC 340
            .|      .||||||:..|.:.|||..:|....||            :|.|.
Human   790 SC------SCPPGFHFWQDTEICKDVDECLSSPCV------------SGVCR------------- 823

  Fly   341 HVNSNQECVNTVGSYSCNCLPG--------FNLDATLNKC---VDINECSINNHNCLPTQRCDNT 394
                     |..|||:|.|.||        |.||:|...|   :..:.|.:|.........|..|
Human   824 ---------NLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLRSECCAT 879

  Fly   395 IGS---YICTRLQ---SCGTGYTLNAETG-NCDDDDECTLSTHNCPSNYDCHNTRGSFRCYRKIS 452
            :|:   ..|.|.:   :|..|:.  ..|| .|||.:||......|| |..|.||.|||||.....
Human   880 LGAAWGSPCERCEIDPACARGFA--RMTGVTCDDVNECESFPGVCP-NGRCVNTAGSFRCECPEG 941

  Fly   453 TMLTTR-------------------TTSTTVP-------------------------PLSLE--- 470
            .||...                   ....|:|                         |.|||
Human   942 LMLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLEFAS 1006

  Fly   471 -------NARRSFTSRYPYPLAVHPEYSQNNDSISTNRRVD---CSPGFYRNTLGA--------- 516
                   .|.|.|.|..|:       |...|:.     :|.   |:.|..|||:|:
Human  1007 LCPRGLGFASRDFLSGRPF-------YKDVNEC-----KVFPGLCTHGTCRNTVGSFHCACAGGF 1059

  Fly   517 --------CIDTNEC-MEQNPCGNHERCINTNGHFRCESLLQCSPGYKSTVDG----KSCIDIDE 568
                    |.|.:|| :..:.|| ...|:||.|.|.||    |.|||:|   |    |:|:|:||
Human  1060 ALDAQERNCTDIDECRISPDLCG-QGTCVNTPGSFECE----CFPGYES---GFMLMKNCMDVDE 1116

  Fly   569 CDTGEHNCGERQICRNRNGGFVCSCPIGHELKRSIGGASTCVDTNECALEQRVCPLNAQCFNTIG 633
            |......| ....|.|.:|.:.|.||.||||...   .:.|.|.:||:|...:|| :.||.|.||
Human  1117 CARDPLLC-RGGTCTNTDGSYKCQCPPGHELTAK---GTACEDIDECSLSDGLCP-HGQCVNVIG 1176

  Fly   634 AYYCECKAGFQKKSDGNNSTQCFDIDECQVIPGLCQQKCLNFWGGYRCTCNSGYQLGPDNRTCND 698
            |:.|.|.||||...|...   |.||:||:|..|.|...|:|..|.|||:|..||.|.||.|.|.|
Human  1177 AFQCSCHAGFQSTPDRQG---CVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRACAD 1238

  Fly   699 INECEVHKDYKLC-MGLCINTPGSYQCSCPRGYILAADMNTCRDVDECATDSINQVC-------- 754
            ::|||  ::.::| .|.|.|.||.::|.|..|::...||.||.|||||  |....:|
Human  1239 VDECE--ENPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDEC--DLNPHICLHGDCENT 1299

  Fly   755 ------------------TGRNDI----------------------------------------- 760
                              ||.:|:
Human  1300 KGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFECHDL 1364

  Fly   761 ---------------CTNIRGSYKCTTVNCPLGYSIDP---EQKNRCRQNLNFCEGEECYTQPSA 807
                           |.|:.|||:||   |..|::.|.   |.::.|.:|::.|:..:|...|..
Human  1365 DECVSQEHRCSPRGDCLNVPGSYRCT---CRQGFAGDGFFCEDRDECAENVDLCDNGQCLNAPGG 1426

  Fly   808 F 808
            :
Human  1427 Y 1427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31999	NP_001284712.1	vWFA	<189..227	CDD:294047	10/40 (25%)
		EGF_CA	251..293	CDD:238011	16/41 (39%)
		EGF_CA	328..>363	CDD:214542	8/42 (19%)
		EGF_CA	519..564	CDD:214542	19/49 (39%)
		EGF_CA	565..601	CDD:238011	15/35 (43%)
		EGF_CA	611..651	CDD:284955	19/39 (49%)
		vWFA	<655..695	CDD:294047	20/39 (51%)
		cEGF	678..701	CDD:289433	12/22 (55%)
		EGF_CA	698..>730	CDD:214542	12/32 (38%)
		cEGF	721..744	CDD:289433	9/22 (41%)
FBN3	XP_016882868.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2524
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940