DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31999 and Ltbp3

DIOPT Version :9

Sequence 1:	NP_001284712.1	Gene:	CG31999 / 43777	FlyBaseID:	FBgn0051999	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	XP_038948570.1	Gene:	Ltbp3 / 83838	RGDID:	62057	Length:	1317	Species:	Rattus norvegicus

Alignment Length:	959	Identity:	223/959 - (23%)
Similarity:	313/959 - (32%)	Gaps:	348/959 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 ISGYIRKCCINGLRHARTTASCKKIDIAPTIIPQLWLGLCHSTLEVCCSRELDHQD--------- 82
            :.|.:...|..|.:...:| .|:  ||...::|    |:|.            |.|
  Rat   330 VRGEVGADCPQGYKRLNST-HCQ--DINECVMP----GMCR------------HGDCLNNPGSYR 375

  Fly    83 --CELGRLAALDGTRCDGEGN--------------------VTSSSYATCCRSCQIGLAVKASKA 125
              |..|.......|:|..:..                    .|..:...||  |.:|   ||..|
  Rat   376 CVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSTEHQCQHPLTTRLTRQLCC--CSVG---KAWGA 435

  Fly   126 NCKDPLFSFIFLIESYRACCYGSADFKD----QPGIDEIDKANSITDEGELPFV----------- 175
            .|:             |....|:|.||:    ..|...:....::|.:||..|.
  Rat   436 RCQ-------------RCPADGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKP 487

  Fly   176 ---------------SEEDMNVTIVLTGDDDICGKIENLCAHICENTFDAYQCKCHPGFMLDNNN 225
                           :||:..||:    |..:..:.....:|....|..|   :.:|..:...:.
  Rat   488 QQLPESPSRAPALEDTEEERGVTL----DPPVSEERSVQQSHPTTTTSPA---RPYPELISRPSP 545

  Fly   226 VTCSPMKTQICPSGYNLDKLDNKCIDIDECREDLHDCKSSQYCHNTNGGYHCLNVKEKECPPGFH 290
            .|.......:.||...::....:..:.||||.:.:.|...|                  |.||
  Rat   546 PTFHRFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGQ------------------CVPG-- 590

  Fly   291 YDHDYDACKDDYKCKDRKCVKIQSCDKGFSLH--NGTCSDIDECSHKSLNNCHVNSNQECVNTVG 353
                    ..||.|         .|:.|:..|  :..|.|::||..:...    .....|:||.|
  Rat   591 --------PSDYSC---------HCNPGYRSHPQHRYCVDVNECEAEPCG----PGRGICMNTGG 634

  Fly   354 SYSCNCLPGFNL--DATLNKCVDINECSINNHNCLPTQRCDNTIGSYICTRLQSCGTGYTL-NAE 415
            ||:|:|..|:.|  .|....|||:|||: ..|.|.....|.|..|.|.|    :|..||.| .:.
  Rat   635 SYNCHCNRGYRLHVGAGGRSCVDLNECA-KPHLCGDGGFCINFPGHYKC----NCYPGYRLKTSR 694

  Fly   416 TGNCDDDDECTLSTHNCPSNYDCHNTRGSFRCYRKISTMLTTRTTSTTVPPLSLENARRSFTSRY 480
            ...|:|.|||. ....||.. .|.|..|||:|
  Rat   695 PPVCEDIDECR-DPSTCPDG-KCENKPGSFKC--------------------------------- 724

  Fly   481 PYPLAVHPEYSQNNDSISTNRRVDCSPGFYRNTLGACIDTNECMEQNPCGNHERCINTNGHFRCE 545
                                  :.|.||:.....|||.|.|||.|.:|| :...|.|..|.:||
  Rat   725 ----------------------IACQPGYRSQGGGACRDINECSEGSPC-SPGWCENLPGSYRC- 765

  Fly   546 SLLQCSPGYKSTVDGKSCIDIDECDTGEHNCGERQICRNRNGGFVCSCPIGHELKRSIGGASTCV 610
               .|:.||:..:||.||||:|||:||  |.....||.|..|.|.|.|..|:.|.|.   .|.|.
  Rat   766 ---TCAQGYEPALDGLSCIDMDECETG--NICHDGICTNTPGSFQCQCLSGYHLSRD---RSHCE 822

  Fly   611 DTNECALEQRVCPLNAQCFNTIGAYYCECKAGFQKKSDGNNSTQCFDIDECQVIPGLC--QQKCL 673
            |.:||.. ...| :...|.||.|:|.|.|..|.:..    ...:|.|||||...||||  ...|.
  Rat   823 DIDECDF-PAAC-IGGDCINTNGSYRCLCPQGHRLV----GGRKCQDIDECSQDPGLCLPHGACE 881

  Fly   674 NFWGGYRCTCNSGYQLGPDNRTCNDINE------------------------------------- 701
            |..|.|.|.|:.|:.|..|...|.::.:
  Rat   882 NLQGSYVCVCDEGFTLTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAG 946

  Fly   702 ----CEV----------------------------------HKDYKLCM---------GLCINTP 719
                ||:                                  |:|...|:         |.|:||.
  Rat   947 WGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECILFGAEICKEGKCVNTQ 1011

  Fly   720 GSYQCSCPRGYILAADMNTCRDVDECATDSINQVCTGRNDICTNIRGSYKCTTVNC--PLGYS-- 780
            ..|:|.|.:|:....::..|.|||||..:|     ..||.:|.|.||.|:|.   |  |..||
  Rat  1012 PGYECYCKQGFYYDGNLLECVDVDECLDES-----NCRNGVCENTRGGYRCA---CTPPAEYSPA 1068

  Fly   781 ----IDPEQKNRCR-----------------QNLNFCEGEECYTQPSAF 808
                :.||:....|                 |:...|....|...|.::
  Rat  1069 QRQCLSPEEMGEARGISAGSRAQEEMDMDECQDPAACRPGRCVNLPGSY 1117

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31999	NP_001284712.1	vWFA	<189..227	CDD:294047	5/37 (14%)
		EGF_CA	251..293	CDD:238011	9/41 (22%)
		EGF_CA	328..>363	CDD:214542	11/34 (32%)
		EGF_CA	519..564	CDD:214542	18/44 (41%)
		EGF_CA	565..601	CDD:238011	16/35 (46%)
		EGF_CA	611..651	CDD:284955	12/39 (31%)
		vWFA	<655..695	CDD:294047	19/41 (46%)
		cEGF	678..701	CDD:289433	7/22 (32%)
		EGF_CA	698..>730	CDD:214542	12/115 (10%)
		cEGF	721..744	CDD:289433	7/22 (32%)
Ltbp3	XP_038948570.1	EGF_CA	352..387	CDD:214542	9/50 (18%)
		TB	412..453	CDD:395554	14/58 (24%)
		PHA03247	<484..574	CDD:223021	12/96 (13%)
		EGF_CA	613..656	CDD:214542	14/46 (30%)
		EGF_CA	657..692	CDD:238011	15/39 (38%)
		EGF_CA	700..733	CDD:214542	15/89 (17%)
		EGF_CA	741..781	CDD:214542	18/44 (41%)
		EGF_CA	782..822	CDD:214542	18/44 (41%)
		EGF_CA	823..862	CDD:214542	12/44 (27%)
		EGF_CA	863..896	CDD:214542	16/32 (50%)
		TB	926..969	CDD:395554	2/42 (5%)
		EGF_CA	1033..>1061	CDD:214542	15/35 (43%)
		EGF_CA	1095..1135	CDD:214542	4/23 (17%)
		TB	1161..>1195	CDD:395554
		EGF_CA	1268..1306	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000