DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31999 and nell1

DIOPT Version :9

Sequence 1:	NP_001284712.1	Gene:	CG31999 / 43777	FlyBaseID:	FBgn0051999	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	XP_031756556.1	Gene:	nell1 / 779470	XenbaseID:	XB-GENE-920228	Length:	829	Species:	Xenopus tropicalis

Alignment Length:	860	Identity:	195/860 - (22%)
Similarity:	279/860 - (32%)	Gaps:	311/860 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 LWLGLCHSTLEVCCS----RELDHQDCELGRLAAL------------DGTRCDGEGNVTSSSYAT 109
            |.:...|..|.|.|:    |.:|..|..|...::|            .|...|.:.....:.|.|
Frog   152 LTVSASHVLLHVDCNRIYERVIDPPDANLSPGSSLWLGQRNRKHGFFKGVIQDVKMIFMPNGYIT 216

  Fly   110 CC----RSCQIGLAVKASKANCKD--PLFSFIFLIESYRACCYGSADFKDQPGIDEIDKANSITD 168
            .|    |:|          ..|.|  .|...|..::...|......::..:|.|       |:|.
Frog   217 QCPNLNRTC----------PTCSDFLSLVQGIMDLQELLAKMTAKLNYASKPRI-------SLTS 264

  Fly   169 E-GELP-FVSEEDMNVTIVLTG-DDDICG------KIENLCAHICENTFDAYQCKCHPGFMLDNN 224
            : |||. ||....|...  ||| .|.|.|      ::.:|.....|.|             ::.|
Frog   265 QRGELHIFVKPTGMLER--LTGVSDGISGASSSSFRLNHLSTGADEET-------------IEGN 314

  Fly   225 NVTCS------PMKTQICPSGYN---LDKLDNKCIDIDEC--------REDLHDCKSSQYCHNTN 272
            ....|      |...::..:||:   .:..|::..:..:|        ..|....||.:.|.|.:
Frog   315 PTVASLHHIDYPPSEEMGMNGYSELLSEAKDHRPTEATKCIYGGKVLAEGDRILTKSCRECKNGS 379

  Fly   273 GGYHCLNVKEKECPP--------------------GFHYDHDYDACKDDYKCKDRKCVKIQSCDK 317
                 |......|||                    |.::..|...|.::.:|::........|..
Frog   380 -----LQKLMDPCPPLNCSEADRVLPENQCCSVCRGHNFCADGHRCGENSECRNHNNKATCECLS 439

  Fly   318 GFSLHNGT---CSDIDECSHKSLNNCHVNSNQECVNTVGSYSCNCLPGF-NLDATLNKCVDINEC 378
            ||....|.   |.|||||:.| ::.||.|:  .|||..|||.|:|:||: .:|..  .|.:.:||
Frog   440 GFQPIQGDPAYCEDIDECAAK-MHYCHANT--VCVNLPGSYRCDCVPGYIRVDDF--SCTEHDEC 499

  Fly   379 SINNHNCLPTQRCDNTIGSYICTRLQSCGTGYTLNAET------------GNCDDDDECTLSTHN 431
            .....:|.....|.|::..:.||    |..||..|...            |.|...::|.
Frog   500 GEGESSCDENAICANSVRGHSCT----CKPGYVGNGTVCRAFCEEGCRYGGTCVAPNKCL----- 555

  Fly   432 CPSNYDCHNTRGSFRCYRKISTMLTTRTTSTTVPPLSLENARRSFTSRYPYPLAVHPEYSQNNDS 496
            |||.:     .|| .|.:.|.
Frog   556 CPSGF-----TGS-HCEKDID-------------------------------------------- 570

  Fly   497 ISTNRRVDCSPGFYRNTLGACIDTNECMEQNPCGNHERCINTNGHFRCESLLQCSPGYKS----T 557
                   :|:.|...                 |.||.||:|..|.|.||    |..|:..    :
Frog   571 -------ECAEGIIE-----------------CHNHSRCVNLPGWFHCE----CRSGFHDNGTYS 607

  Fly   558 VDGKSCIDIDECDTGEHNCGERQICRNRNGGFVCSCPIG--------HE--LKRSIGGASTCVDT 612
            :.|:||:|||||....|.|.....|.|..|||.|.||.|        ||  |||:  |....:..
Frog   608 ISGESCVDIDECALRTHTCWNDSACVNLEGGFDCLCPSGPSCTGDCPHEGGLKRN--GQVWTLKE 670

  Fly   613 NECALEQRVCPLNAQCFNTIGAYYCECKAG--FQKKSD---GNNSTQCFDIDECQVIPGLCQQKC 672
            :.|::                   |.||.|  |.:::.   .|.|...|...||..   ....:|
Frog   671 DRCSV-------------------CSCKDGKIFCRRTACDCQNPSVDLFCCPECDT---RVTSQC 713

  Fly   673 LNFWGGYRCTCNSGYQLGPDNRTCNDINECEVHKDYKLCMGLCINTPGSYQC---SCPRGYILAA 734
            |:..|      :..|..| ||.|.: ..:|.           |:.  |...|   :||   ||..
Frog   714 LDQTG------HKVYHSG-DNWTYS-CQQCR-----------CLE--GEVDCWPLTCP---ILTC 754

  Fly   735 DMNT---------CRDVDECATD----SINQVCTGRNDICTNIRGSY------KCTTVNCPLG-- 778
            :..|         |.| |.|..|    .|.:.|.....| |.:.||.      .|||..|..|
Frog   755 EYTTISEGECCPHCVD-DPCIADGDPYDIRKTCQDPQGI-TRLGGSVWTMVGSPCTTCKCKNGSV 817

  Fly   779 -YSIDPEQKNRCRQN 792
             .|:|.:    |..|
Frog   818 CCSVDLD----CLHN 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31999	NP_001284712.1	vWFA	<189..227	CDD:294047	7/43 (16%)
		EGF_CA	251..293	CDD:238011	11/69 (16%)
		EGF_CA	328..>363	CDD:214542	18/34 (53%)
		EGF_CA	519..564	CDD:214542	14/48 (29%)
		EGF_CA	565..601	CDD:238011	19/45 (42%)
		EGF_CA	611..651	CDD:284955	6/44 (14%)
		vWFA	<655..695	CDD:294047	10/39 (26%)
		cEGF	678..701	CDD:289433	5/22 (23%)
		EGF_CA	698..>730	CDD:214542	6/34 (18%)
		cEGF	721..744	CDD:289433	8/34 (24%)
nell1	XP_031756556.1	TSPN	27..211	CDD:214560	12/58 (21%)
		VWC	354..408	CDD:327433	10/58 (17%)
		EGF_CA	453..>485	CDD:214542	18/34 (53%)
		EGF_3	499..534	CDD:403986	10/38 (26%)
		EGF_CA	568..605	CDD:214542	15/108 (14%)
		EGF_CA	615..653	CDD:214542	16/37 (43%)
		VWC	653..705	CDD:327433	15/72 (21%)
		VWC	720..768	CDD:327433	14/65 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000