DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG31999 and THBD

DIOPT Version :9

Sequence 1:NP_001284712.1 Gene:CG31999 / 43777 FlyBaseID:FBgn0051999 Length:917 Species:Drosophila melanogaster
Sequence 2:NP_000352.1 Gene:THBD / 7056 HGNCID:11784 Length:575 Species:Homo sapiens


Alignment Length:587 Identity:128/587 - (21%)
Similarity:194/587 - (33%) Gaps:186/587 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   229 SPMKTQICPSGYNLDKLDNKCIDIDECREDLHDC-----------KSSQYCHNTNGGYHCLNVKE 282
            :|.:.|  |.|       ::|::        |||           .:||.|....|  |.:.|:.
Human    19 APAEPQ--PGG-------SQCVE--------HDCFALYPGPATFLNASQICDGLRG--HLMTVRS 64

  Fly   283 K-------------------------ECPPGFHYDHDYDACKDDYKCKDRKCVKIQSCDKGFSLH 322
            .                         :.|||               |.|.|.:   ...:||...
Human    65 SVAADVISLLLNGDGGVGRRRLWIGLQLPPG---------------CGDPKRL---GPLRGFQWV 111

  Fly   323 NGTCSDIDECSHKSLNNCHVNSNQECVNTVGSYSCNCLPGFNLDATLNKCVDIN--ECSINNHNC 385
            .|.    :..|:.......:|         |:..|..|           ||.::  |.::.:...
Human   112 TGD----NNTSYSRWARLDLN---------GAPLCGPL-----------CVAVSAAEATVPSEPI 152

  Fly   386 LPTQRCDNTIGSYICTRLQSCGTGYTLNAETGNCDDDDECTLSTHNCPSNYDCHNTRGSFRCYRK 450
            ...|:|:.....::| ......|...|..|.|........|..|.......|          ::.
Human   153 WEEQQCEVKADGFLC-EFHFPATCRPLAVEPGAAAAAVSITYGTPFAARGAD----------FQA 206

  Fly   451 ISTMLTTRTTSTTVPPLSLENARRSFTSRYPYPLAVHPEYSQNNDSISTNRRVDCSPGFYRNTLG 515
            :..     .:|..|.||.|:     .....| |.||...:::.            :||.:     
Human   207 LPV-----GSSAAVAPLGLQ-----LMCTAP-PGAVQGHWARE------------APGAW----- 243

  Fly   516 ACIDTNECMEQNPCGNHERCINTNGHFRCESLLQCSPGYKSTVDGKSCI--DIDEC-DTGEHNCG 577
                  :|..:|. |....|....|..||    ||..|.....||:||.  ....| |..||.|.
Human   244 ------DCSVENG-GCEHACNAIPGAPRC----QCPAGAALQADGRSCTASATQSCNDLCEHFCV 297

  Fly   578 ERQICRNRNGGFVCSCPIGHELKRSIGGASTCVDTNECALEQRVCPLNAQCFNTIGAYYCECKAG 642
            ...   ::.|.:.|.|..|:.|   ......|.|.::|.||...||  .:|.||.|.:.|.|...
Human   298 PNP---DQPGSYSCMCETGYRL---AADQHRCEDVDDCILEPSPCP--QRCVNTQGGFECHCYPN 354

  Fly   643 FQKKSDGNNSTQCFD-IDECQVIPGLCQQKC--LNFWGGYRCTCNSGYQLGPDNRTCNDINECEV 704
            :. ..||    :|.: :|.|  ....|:.:|  || ...|.|.|..|:...|     ::.:.|::
Human   355 YD-LVDG----ECVEPVDPC--FRANCEYQCQPLN-QTSYLCVCAEGFAPIP-----HEPHRCQM 406

  Fly   705 HKDYKLCMGLC-INTPGSYQCSCPRGYILAADMNTCRDVDECATDSINQVCTGRNDICTNIRGSY 768
            ..:...|...| .||..|  |.||.|||| .|...|.|:|||.....   |:|   :|.|:.|::
Human   407 FCNQTACPADCDPNTQAS--CECPEGYIL-DDGFICTDIDECENGGF---CSG---VCHNLPGTF 462

  Fly   769 KC 770
            :|
Human   463 EC 464

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31999NP_001284712.1 vWFA <189..227 CDD:294047
EGF_CA 251..293 CDD:238011 12/77 (16%)
EGF_CA 328..>363 CDD:214542 5/34 (15%)
EGF_CA 519..564 CDD:214542 13/44 (30%)
EGF_CA 565..601 CDD:238011 10/36 (28%)
EGF_CA 611..651 CDD:284955 14/39 (36%)
vWFA <655..695 CDD:294047 12/42 (29%)
cEGF 678..701 CDD:289433 5/22 (23%)
EGF_CA 698..>730 CDD:214542 9/32 (28%)
cEGF 721..744 CDD:289433 11/22 (50%)
THBDNP_000352.1 CLECT_thrombomodulin_like 30..171 CDD:153070 30/193 (16%)
FXa_inhibition 245..280 CDD:291342 12/39 (31%)
FXa_inhibition 289..323 CDD:291342 9/39 (23%)
EGF_CA 325..>355 CDD:214542 12/31 (39%)
Tme5_EGF_like 406..439 CDD:286192 13/35 (37%)
EGF_CA 441..>468 CDD:214542 10/30 (33%)
Involved in alpha-L/beta-2 and alpha-M/beta-2 integrin binding. /evidence=ECO:0000269|PubMed:27055590 481..515
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 484..506
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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