DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31999 and npnta

DIOPT Version :9

Sequence 1:	NP_001284712.1	Gene:	CG31999 / 43777	FlyBaseID:	FBgn0051999	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	XP_009292491.1	Gene:	npnta / 563273	ZFINID:	ZDB-GENE-090312-201	Length:	636	Species:	Danio rerio

Alignment Length:	391	Identity:	114/391 - (29%)
Similarity:	148/391 - (37%)	Gaps:	116/391 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   489 EYSQNNDSISTNRRVDCSPGFYRNTLGAC---------IDTNECMEQNPCGN---HERCINTNGH 541
            :.|.:|.......|:||..|:.|.:.|.|         :....|..|..|.:   |..|:..|
Zfish    27 QMSSSNGLCRYGGRIDCCWGWTRVSWGQCQPLYVLTRRVIGIRCQPQALCQHGCKHGECVGPN-- 89

  Fly   542 FRCESLLQCSPGYKSTVDGKSCIDIDECDTGEHNCGERQICRNRNGGFVCSCPIGHEL------- 599
             :|    :|.|||    .||:|           |..||        ||| |.|:.|..
Zfish    90 -KC----KCHPGY----TGKTC-----------NQDER--------GFV-SPPLWHSHAPVFVPM 125

  Fly   600 -KRSIGGASTCVDTNECALEQRVCPLNAQCFNTIGAYYCECKAGFQKKSDGNNSTQCFDIDECQV 663
             .:.|...|.  |.|||.|:.|.|  ..:|.||.|::.|.|..||....||:    |.:...|.:
Zfish   126 DHQPIAAPSE--DLNECGLKPRPC--KHRCMNTFGSFKCYCLNGFMLLPDGS----CANARTCSM 182

  Fly   664 IPGLCQQKCLNFWGGYRCTCNS-GYQLGPDNRTCNDINECEVHKDYKLCMGL--------CINTP 719
              ..||..|....|..||.|.| |.||.||.|||.|::||        ..||        ||||.
Zfish   183 --ANCQYGCEVMKGEVRCQCPSPGLQLAPDGRTCVDVDEC--------AAGLAVCPRFRKCINTF 237

  Fly   720 GSYQCSCPRGYIL--AADMNTCRDVDECATDSINQVCTGRNDICTNIRGSYKCTTVNCP-----L 777
            |||.|.|..|:.|  ......|.||:||   |:.|...|....|.|..|||||   .|.     :
Zfish   238 GSYICKCHDGFDLQYVNGKYQCTDVNEC---SLGQHQCGPYATCYNTPGSYKC---KCKEDYRGV 296

  Fly   778 GYS--------IDPEQKNRCRQNLNFCEGEECYTQPSAFTYNFITFVSKLMIPPDGRTIFTLRGP 834
            ||.        |||.:..:...:.|..:|.                 :|:......||..|:|.|
Zfish   297 GYDCKPIPKVVIDPPRPGKTTPSSNNNKGG-----------------NKIPGSDQKRTTTTVRPP 344

  Fly   835 L 835
            :
Zfish   345 V 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31999	NP_001284712.1	vWFA	<189..227	CDD:294047
		EGF_CA	251..293	CDD:238011
		EGF_CA	328..>363	CDD:214542
		EGF_CA	519..564	CDD:214542	13/47 (28%)
		EGF_CA	565..601	CDD:238011	9/43 (21%)
		EGF_CA	611..651	CDD:284955	17/39 (44%)
		vWFA	<655..695	CDD:294047	15/40 (38%)
		cEGF	678..701	CDD:289433	13/23 (57%)
		EGF_CA	698..>730	CDD:214542	14/39 (36%)
		cEGF	721..744	CDD:289433	9/24 (38%)
npnta	XP_009292491.1	EGF_CA	136..168	CDD:238011	15/33 (45%)
		cEGF	197..219	CDD:289433	13/21 (62%)
		EGF_CA	216..>248	CDD:284955	14/39 (36%)
		EGF_3	265..300	CDD:289699	14/40 (35%)
		MAM	487..629	CDD:279023
		MAM	487..627	CDD:99706
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	48	1.000	Domainoid score	I11922
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.000