DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31999 and lrp13

DIOPT Version :9

Sequence 1:	NP_001284712.1	Gene:	CG31999 / 43777	FlyBaseID:	FBgn0051999	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	XP_021327248.1	Gene:	lrp13 / 562438	ZFINID:	ZDB-GENE-130729-1	Length:	1354	Species:	Danio rerio

Alignment Length:	724	Identity:	160/724 - (22%)
Similarity:	234/724 - (32%)	Gaps:	254/724 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 LRHARTTASCKKIDIAPTIIPQLWLG--LCHSTLEVCCSRELDHQDCELGRLAALDGTRCDGEGN 101
            ||..|..|:....|:|   :|...||  ||.           |...|      .|:...||||.:
Zfish    17 LRAERVLAAVVSEDVA---LPYCRLGFQLCE-----------DRSGC------VLNTHLCDGEND 61

  Fly   102 VTSSSYATCCRS-CQIGLAVKASKANCKDPLFSFIFLIESYRACCYGSADFKDQPGIDEIDKANS 165
            ....|....|.: |.:|....|....|       |:|    |..|.|....:|:.  ||::
Zfish    62 CDDGSDEDNCPTVCSVGHFQCAHGKMC-------IWL----RQVCDGVPQCQDRS--DELN---- 109

  Fly   166 ITDEGELPFVSEEDMNVTIVLTGDDDICGKIENLCAHICE-NTFDAYQCKCHPGFMLDNNNVTCS 229
                                       |.|.::.|||.|: ||      :|.|...:.:.:|.|.
Zfish   110 ---------------------------CFKPDDGCAHRCDGNT------RCVPESFVCDGDVDCV 141

  Fly   230 PMKTQICPSGYNLDKLDNKCIDIDECREDLHDCKS--------SQYCHNTNGGYHCLNVKEKECP 286
            ....:.     |.:..|    |.|:..|||.|.|.        ||....|.|...| ::..|.|.
Zfish   142 DGSDEA-----NCENPD----DDDDDDEDLLDEKEEMTGEHEVSQNVPATKGPLRC-SIASKLCR 196

  Fly   287 PGFHYDHDYDACKDDYKCKD----RKCVKIQSCDKG-FSLHNG--------TCSDIDECSHKSLN 338
            .|.........|..:..|||    ..| .:| |:.| |...:|        .|..:.:|..:
Zfish   197 DGTDCVMLNHVCDGELDCKDGSDEEDC-PVQ-CESGQFQCAHGKKCIDRRQLCDGVPQCQDR--- 256

  Fly   339 NCHVNSNQECVNTVGSYSCNCLPGFNLDATLNKCVDINECSINNHNCLPTQRCDNTIGSYICTRL 403
                           |...||   |..|         ::|:   |.|....||  ...|::|...
Zfish   257 ---------------SDELNC---FKPD---------DDCA---HRCDENTRC--VPESFVCDGD 289

  Fly   404 QSCGTGYTLNAETGNCDDDD-----------ECTLSTHNCPSNYDCHNTRGSFRCYRKISTMLTT 457
            ..|..|    ::..||.::.           :|...:..|..:.||.:......|
Zfish   290 PDCVDG----SDEANCGEESCSSAEWQCSSGQCVSLSMRCDGHSDCRDHSDEEDC---------- 340

  Fly   458 RTTSTTVPPLSLENARRSFTSRYPYPLAVHPEYSQNNDSISTNRRVDCSPGFYRNTLGACIDTNE 522
                 ..||                             ..|||||              |..::|
Zfish   341 -----AEPP-----------------------------PCSTNRR--------------CPKSHE 357

  Fly   523 C-MEQNPCGNHERCINTNGHFRC-ESLLQCSPGYKSTVDGKSCIDIDECDTGEHNCGERQICRNR 585
            | :::..|.....|.:......| ||.:||.. |:.     ||....:|......|...:.||:.
Zfish   358 CLLDEWMCDGETDCKDGTDEKNCKESPVQCGE-YQF-----SCSSKTQCIPQSWRCDGSEDCRDG 416

  Fly   586 NGGFVC---SCPIGH----------ELKRSIGGASTCVD---------TNECALEQRVCPLNAQ- 627
            :....|   ||| .|          |..:...|.:.|:|         |.:|: ||..|   ||
Zfish   417 SDESACASVSCP-PHLFQCGSSECVEFSQLCNGVTNCLDGSDEGGSCQTEKCS-EQLKC---AQD 476

  Fly   628 CFNTIGAYYCECKAGFQKKSDGNNSTQCFDIDECQVIPGLCQQKCLNFWGGYRCTCNSGYQLGPD 692
            |.:|.....|.|:.|::...||   .:|.|:|||...|.:|..:|.|..|.::|:|:.||.|.||
Zfish   477 CHSTPAGARCGCRMGYKPVDDG---LRCADVDECVERPNICSHRCNNTLGSFQCSCSHGYVLEPD 538

  Fly   693 NRTCNDINE 701
            ..:|....|
Zfish   539 GHSCKITGE 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31999	NP_001284712.1	vWFA	<189..227	CDD:294047	10/38 (26%)
		EGF_CA	251..293	CDD:238011	15/49 (31%)
		EGF_CA	328..>363	CDD:214542	4/34 (12%)
		EGF_CA	519..564	CDD:214542	11/46 (24%)
		EGF_CA	565..601	CDD:238011	10/48 (21%)
		EGF_CA	611..651	CDD:284955	15/49 (31%)
		vWFA	<655..695	CDD:294047	17/39 (44%)
		cEGF	678..701	CDD:289433	8/22 (36%)
		EGF_CA	698..>730	CDD:214542	1/4 (25%)
		cEGF	721..744	CDD:289433
lrp13	XP_021327248.1	LDLa	36..71	CDD:238060	12/51 (24%)
		LDLa	75..110	CDD:238060	12/78 (15%)
		LDLa	119..149	CDD:238060	8/40 (20%)
		LDLa	195..223	CDD:238060	6/27 (22%)
		LDLa	227..262	CDD:238060	7/52 (13%)
		LDLa	271..301	CDD:238060	8/35 (23%)
		LDLa	306..340	CDD:238060	4/33 (12%)
		LDLa	351..380	CDD:238060	6/42 (14%)
		LDLa	387..422	CDD:238060	8/40 (20%)
		LDLa	427..458	CDD:197566	7/31 (23%)
		EGF_CA	503..542	CDD:311536	16/38 (42%)
		PHA02142	<569..>666	CDD:333147
		LY	<622..648	CDD:214531
		Ldl_recept_b	680..718	CDD:278487
		LY	702..744	CDD:214531
		LY	744..786	CDD:214531
		FXa_inhibition	818..848	CDD:317114
		LY	976..1021	CDD:214531
		FXa_inhibition	1130..1162	CDD:317114
		LDLa	1170..1202	CDD:197566
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24034
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.100