DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31999 and fbln2

DIOPT Version :9

Sequence 1:	NP_001284712.1	Gene:	CG31999 / 43777	FlyBaseID:	FBgn0051999	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	XP_001341277.2	Gene:	fbln2 / 553503	ZFINID:	ZDB-GENE-060711-1	Length:	1408	Species:	Danio rerio

Alignment Length:	938	Identity:	286/938 - (30%)
Similarity:	404/938 - (43%)	Gaps:	202/938 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 GYIRKCCINGLRHARTTASCKKIDIAPTIIPQLWLGLCHSTLEVCCSRELDHQDCELGRLAALDG 93
            |.:..||:.|.:.|.....|.::.:....|.    .:|....:.|||..|....|:.|.:||..|
Zfish   616 GLVESCCVAGQKWAEENQQCNRMAVKTEDIS----SVCGVVQQQCCSGALRESRCQAGIIAAKAG 676

  Fly    94 TRCD------GEGNVTSSSYATCCRSCQIGLAVKASKANCKDPLF-----SFIFLIESYRACCYG 147
            ..|.      ||.:.|.     ||..|.:||.::.....|:...:     ..:||     .||..
Zfish   677 RACQRNSPLCGEDSQTD-----CCNCCALGLRLRREGKGCEAHQYLSYPCGHVFL-----TCCED 731

  Fly   148 SADFKDQPGIDEIDKANSITDEGELP-FVSEEDMNVTIVLTGD-------------DDICGKIEN 198
            :.:....|.|    |.........|| .||:.......:..||             .|.|.:..:
Zfish   732 AEEGLPLPTI----KKKQRPQPTALPKRVSDSQFWKQALSAGDVDPAVNSLEDLEHGDRCQRFAS 792

  Fly   199 LCAHICENTFDAYQCKCHPGFMLDNNNVTCSPMKTQICPSGYNLDKLDNKCIDIDECREDLHDCK 263
            ||.|.|.||.|:|.|.||||:.|..:..||         ...|.:: ||:..:.|.....:.|
Zfish   793 LCHHTCINTRDSYLCACHPGYTLLQDGHTC---------VSENQEE-DNRVSEEDRIPTTVPD-- 845

  Fly   264 SSQYCHNTNGGYHCLNVKEKECP--PGFHYDHDYDACKDDYKCKDRKCVKIQ-----SCDKGFSL 321
                             |::...  |..|     :.|..:..| .:||..:|     ||..||.|
Zfish   846 -----------------KQQTTTQMPVLH-----NPCAGNGLC-SQKCTVVQELAQCSCFPGFFL 887

  Fly   322 --HNGTCSDIDECSHKSLNNCHVNSNQECVNTVGSYSCN-----CLPGF----NLDATLNKCVDI 375
              ...||.|::||.: ..:||.:  ::.|.|..|||.|.     |..||    |.|     |||:
Zfish   888 KPDGHTCEDVNECLN-GRHNCSL--DEVCKNHEGSYQCERVNEMCHKGFIHKHNRD-----CVDV 944

  Fly   376 NECSINNHNCLPTQRCDNTIGSYICTRLQSCGTGYTLNAETGNCDDDDECTLSTHNCPSNYDCHN 440
            |||..|.|.|...:||.|::|.::|.|:..|.:||.|  ..|.|:|.|||.:.||||...:.|.|
Zfish   945 NECVTNTHTCRADERCVNSVGGFVCERMILCSSGYQL--RNGVCEDIDECVIRTHNCGMGFQCQN 1007

  Fly   441 TRGSFRCYRKISTMLTTRTTSTTVPPLSLENARRSFTSRYPYPLAVHPEYSQNNDSISTNRRVDC 505
            |.|||.|..|                                                  :|  |
Zfish  1008 TDGSFTCKPK--------------------------------------------------QR--C 1020

  Fly   506 SPGFYRNTLGACIDTNECME-QNPCGNHERCINTNGHFRCE-SLLQCSPGYKSTVDGKSCIDIDE 568
            ..||.:::.|.|||.:||.. :.||.....||||.|.:.|: .::.||.||.|:.||..|||:||
Zfish  1021 LTGFTQDSHGNCIDIDECSSVREPCTTGFNCINTVGSYTCQRKIIMCSRGYHSSPDGARCIDVDE 1085

  Fly   569 CDTGEHNCGERQICRNRNGGFVCSCPIGHELK--RSIGGASTCVDTNEC-ALEQRVCPLNAQ-CF 629
            |.||.|.|||.|||.|..|...|.|..|::..  |.:     |||.||| ....|:|   || |.
Zfish  1086 CQTGTHRCGEGQICHNLPGSHRCDCQTGYQYDTIRQL-----CVDVNECWRYPGRLC---AQTCE 1142

  Fly   630 NTIGAYYCECKAGFQKKSDGNNSTQCFDIDECQVIPGLCQQKCLNFWGGYRCTCNSGYQLGPDNR 694
            ||.|:|.|.|..||....||.|   |.||:||...|  |.|:|.|.:|.|:|.|.:||.|..|..
Zfish  1143 NTPGSYQCSCTTGFSLAFDGKN---CEDINECDSNP--CSQECANIYGSYQCYCRAGYYLKEDGH 1202

  Fly   695 TCNDINECEVHKDYKLCMGLCINTPGSYQCSC-PRGYILAADMNTCRDVDECATDSINQVCTGRN 758
            ||.||:||. .....||...|:|.||||.|:| |.||.::|:..||:|:||||..|.|  |:. :
Zfish  1203 TCEDIDECS-QSIGNLCAFECVNVPGSYTCACPPHGYSMSANGRTCQDIDECAIGSHN--CSA-S 1263

  Fly   759 DICTNIRGSYKCTTVNCPLGYSIDPEQKNRCRQNLNFCEGEECYTQPSAFTYNFITFVSKLMIPP 823
            ..|.||:|.::|....||..|.  .....|| :.::....::|.|.|...||..::|.:.::||.
Zfish  1264 QTCFNIQGGFRCLLFECPDNYR--RVSDIRC-ERMSCPNYQQCQTMPLRITYYQLSFQTNIVIPA 1325

  Fly   824 DGRTIFTLRGPLWY--DNIEFDLKIVRIQATTNIQKATDGSFDTLQNNNQVN-VILKKSLEGPQD 885
            .   ||.:.....|  |||     |:.|.....     ||.|.|.:.|:... |.|.:.:..|:|
Zfish  1326 Q---IFRIGPSPAYSGDNI-----IISIPRGNE-----DGYFSTRKLNSFTGAVYLHRQVREPRD 1377

  Fly   886 IELELSMTVYTNGMPRGKSVAKLFLFVS 913
            ..:::.|.:...| .....:|::::|::
Zfish  1378 FFIDVEMKLLRQG-TFTTFLARIYVFIT 1404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31999	NP_001284712.1	vWFA	<189..227	CDD:294047	17/50 (34%)
		EGF_CA	251..293	CDD:238011	5/43 (12%)
		EGF_CA	328..>363	CDD:214542	12/39 (31%)
		EGF_CA	519..564	CDD:214542	18/46 (39%)
		EGF_CA	565..601	CDD:238011	18/37 (49%)
		EGF_CA	611..651	CDD:284955	19/41 (46%)
		vWFA	<655..695	CDD:294047	18/39 (46%)
		cEGF	678..701	CDD:289433	11/22 (50%)
		EGF_CA	698..>730	CDD:214542	15/32 (47%)
		cEGF	721..744	CDD:289433	11/23 (48%)
fbln2	XP_001341277.2	ANATO	694..734	CDD:294031	10/44 (23%)
		FXa_inhibition	794..822	CDD:291342	13/27 (48%)
		cEGF	878..899	CDD:289433	8/20 (40%)
		EGF_CA	896..>922	CDD:304395	10/28 (36%)
		EGF_CA	943..>980	CDD:284955	15/36 (42%)
		EGF_CA	988..1032	CDD:304395	21/95 (22%)
		EGF_CA	1034..1081	CDD:214542	18/46 (39%)
		EGF_CA	1082..1115	CDD:214542	18/32 (56%)
		vWFA	<1116..1164	CDD:294047	22/55 (40%)
		cEGF	1147..1170	CDD:289433	11/25 (44%)
		cEGF	1186..1209	CDD:289433	11/22 (50%)
		cEGF	1228..1252	CDD:289433	11/23 (48%)
		EGF_CA	1249..>1285	CDD:284955	15/38 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12200
eggNOG	1	0.900	-	-		E33208_3BC1W
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H1514
Inparanoid	1	1.050	376	1.000	Inparanoid score	I2049
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D106706at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26619
orthoMCL	1	0.900	-	-		OOG6_106295
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2524
SonicParanoid	1	1.000	-	-		X2629
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.800