DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31999 and LTBP3

DIOPT Version :9

Sequence 1:	NP_001284712.1	Gene:	CG31999 / 43777	FlyBaseID:	FBgn0051999	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	XP_011543334.1	Gene:	LTBP3 / 4054	HGNCID:	6716	Length:	1312	Species:	Homo sapiens

Alignment Length:	944	Identity:	222/944 - (23%)
Similarity:	311/944 - (32%)	Gaps:	334/944 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 ISGYIRKCCINGLRHARTTASCKKIDIAPTIIPQLWLGLCHSTLEVCCSRELDHQD--------- 82
            :.|.:...|..|.:...:| .|:  ||....:|    |:|.            |.|
Human   342 VRGEVGADCPQGYKRLNST-HCQ--DINECAMP----GVCR------------HGDCLNNPGSYR 387

  Fly    83 --CELGRLAALDGTRCDGEGN--------------------VTSSSYATCCRSCQIGLAVKASKA 125
              |..|.......|:|..:..                    .|..:...||  |.:|   ||..|
Human   388 CVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCC--CSVG---KAWGA 447

  Fly   126 NCKDPLFSFIFLIESYRACCYGSADFKD----QPGIDEIDKANSITDEGELPFV----------- 175
            .|:             |....|:|.||:    ..|...:....::|.:||..|.
Human   448 RCQ-------------RCPTDGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKP 499

  Fly   176 ---------------SEEDMNVTIVLTGDDDICGKIENLCAHICENTFDAYQCKCHPGFMLDNNN 225
                           :||:..||.    |..:..:.....:|....|..|   :.:|..:...:.
Human   500 QQLPESPSQAPPPEDTEEERGVTT----DSPVSEERSVQQSHPTATTTPA---RPYPELISRPSP 557

  Fly   226 VTCSPMKTQICPSGYNLDKLDNKCIDIDECREDLHDCKSSQYCHNTNGGYHCLNVKEKECPPGFH 290
            .|.......:.||...::....:..:.||||.:.:.|...                  ||.||
Human   558 PTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHG------------------ECVPG-- 602

  Fly   291 YDHDYDACKDDYKCKDRKCVKIQSCDKGFSLH--NGTCSDIDECSHKSLNNCHVNSNQECVNTVG 353
                    ..||.|         .|:.|:..|  :..|.|::||..:...    .....|:||.|
Human   603 --------PPDYSC---------HCNPGYRSHPQHRYCVDVNECEAEPCG----PGRGICMNTGG 646

  Fly   354 SYSCNCLPGFNL--DATLNKCVDINECSINNHNCLPTQRCDNTIGSYICTRLQSCGTGYTLNAET 416
            ||:|:|..|:.|  .|....|||:|||: ..|.|.....|.|..|.|.|    :|..||.|.|..
Human   647 SYNCHCNRGYRLHVGAGGRSCVDLNECA-KPHLCGDGGFCINFPGHYKC----NCYPGYRLKASR 706

  Fly   417 GN-CDDDDECTLSTHNCPSNYDCHNTRGSFRCYRKISTMLTTRTTSTTVPPLSLENARRSFTSRY 480
            .. |:|.|||. ...:||.. .|.|..|||:|
Human   707 PPVCEDIDECR-DPSSCPDG-KCENKPGSFKC--------------------------------- 736

  Fly   481 PYPLAVHPEYSQNNDSISTNRRVDCSPGFYRNTLGACIDTNECMEQNPCGNHERCINTNGHFRCE 545
                                  :.|.||:.....|||.|.|||.|.:|| :...|.|..|.|||
Human   737 ----------------------IACQPGYRSQGGGACRDVNECAEGSPC-SPGWCENLPGSFRC- 777

  Fly   546 SLLQCSPGYKSTVDGKSCIDIDECDTGEHNCGERQICRNRNGGFVCSCPIGHELKRSIGGASTCV 610
               .|:.||....||:||:|:|||:.|: .| :..||.|..|.|.|.|..|:.|.|.   .|.|.
Human   778 ---TCAQGYAPAPDGRSCLDVDECEAGD-VC-DNGICSNTPGSFQCQCLSGYHLSRD---RSHCE 834

  Fly   611 DTNECALEQRVCPLNAQCFNTIGAYYCECKAGFQKKSDGNNSTQCFDIDECQVIPGLC--QQKCL 673
            |.:||.. ...| :...|.||.|:|.|.|..|.:..    ...:|.|||||...|.||  ...|.
Human   835 DIDECDF-PAAC-IGGDCINTNGSYRCLCPQGHRLV----GGRKCQDIDECSQDPSLCLPHGACK 893

  Fly   674 NFWGGYRCTCNSGYQLGPDNRTCNDINE------------------------------------- 701
            |..|.|.|.|:.|:....|...|.::.:
Human   894 NLQGSYVCVCDEGFTPTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAG 958

  Fly   702 ----CEV----------------------------------HKDYKLCM---------GLCINTP 719
                ||:                                  |:|...||         |.|:||.
Human   959 WGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQ 1023

  Fly   720 GSYQCSCPRGYILAADMNTCRDVDECATDSINQVCTGRNDICTNIRGSYKCTTVNC--PLGYS-- 780
            ..|:|.|.:|:....::..|.|||||..:|     ..||.:|.|.||.|:|.   |  |..||
Human  1024 PGYECYCKQGFYYDGNLLECVDVDECLDES-----NCRNGVCENTRGGYRCA---CTPPAEYSPA 1080

  Fly   781 ----IDPEQK--NRCRQNLNFCEGEECYTQPSAF 808
                :.||:.  :.| |:...|....|...|.::
Human  1081 QRQCLSPEEMDVDEC-QDPAACRPGRCVNLPGSY 1113

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31999	NP_001284712.1	vWFA	<189..227	CDD:294047	5/37 (14%)
		EGF_CA	251..293	CDD:238011	9/41 (22%)
		EGF_CA	328..>363	CDD:214542	11/34 (32%)
		EGF_CA	519..564	CDD:214542	19/44 (43%)
		EGF_CA	565..601	CDD:238011	15/35 (43%)
		EGF_CA	611..651	CDD:284955	12/39 (31%)
		vWFA	<655..695	CDD:294047	17/41 (41%)
		cEGF	678..701	CDD:289433	6/22 (27%)
		EGF_CA	698..>730	CDD:214542	13/115 (11%)
		cEGF	721..744	CDD:289433	7/22 (32%)
LTBP3	XP_011543334.1	EGF_CA	364..399	CDD:214542	9/50 (18%)
		TB	424..459	CDD:279073	11/52 (21%)
		EGF_CA	625..668	CDD:214542	14/46 (30%)
		EGF_CA	669..703	CDD:238011	14/38 (37%)
		EGF_CA	712..745	CDD:214542	15/89 (17%)
		EGF_CA	753..792	CDD:214542	18/43 (42%)
		EGF_CA	794..834	CDD:214542	17/44 (39%)
		EGF_CA	835..874	CDD:214542	12/44 (27%)
		EGF_CA	875..908	CDD:214542	15/32 (47%)
		TB	938..975	CDD:279073	2/36 (6%)
		EGF_CA	1045..>1073	CDD:214542	15/35 (43%)
		EGF_CA	1091..1126	CDD:214542	5/24 (21%)
		TB	1157..1190	CDD:279073
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	1.870