DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31999 and Crb2

DIOPT Version :9

Sequence 1:	NP_001284712.1	Gene:	CG31999 / 43777	FlyBaseID:	FBgn0051999	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_001129233.1	Gene:	Crb2 / 366031	RGDID:	1309368	Length:	1283	Species:	Rattus norvegicus

Alignment Length:	718	Identity:	151/718 - (21%)
Similarity:	212/718 - (29%)	Gaps:	324/718 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 NLCAHICENTFDAYQCKCHPGF---MLDNNNVTCSPMKTQICPSGYNLDKLDNKCIDIDECREDL 259
            |:||          ...|.||.   ..::...||.|::...|
  Rat    41 NVCA----------SDPCAPGTRCQATESGGFTCEPLELGGC----------------------- 72

  Fly   260 HDCKSSQYCHN---------TNGGYHCLNVKEKECPPGFHYDHDYDACKDDYKCKDRKCVKIQSC 315
                ::|.||:         ...|:.|.      |.|||...|                     |
  Rat    73 ----AAQPCHHGALCVPQGPDPNGFRCY------CVPGFQGPH---------------------C 106

  Fly   316 DKGFSLHNGTCSDIDECSHKSLNNCHVNSNQECVNTVGSYSCNCLPGFNLDATLNKCVDINECSI 380
            :          .|||||:.:.   ||....  |.|....|.|:|..|:   |.:....:::|||
  Rat   107 E----------LDIDECASRP---CHHGGT--CRNLADHYECHCPLGY---AGVTCEAEVDECS- 152

  Fly   381 NNHNCLPTQRCDNTIGSYICTRLQSCGTGYTLNAETGNCD-DDDECTLSTHNCPSNYDCHNTRGS 444
             :..||....|.:.:|||.|.    |..||.    ..:|. |.|||  .:..|.....||:....
  Rat   153 -SAPCLHGGSCLDGVGSYRCV----CAPGYA----GASCQLDVDEC--QSQPCEHGGVCHDLVNG 206

  Fly   445 FRCYRKISTMLTTRTTSTTVPPLSLENARRSFTSRYPYPLAVHPEYSQNNDSISTNRRVDCSPGF 509
            |||                                                        ||:...
  Rat   207 FRC--------------------------------------------------------DCADTG 215

  Fly   510 YRNTLGACIDTN--ECMEQNPCGNHERCINTNGHFRCESLLQCSPGYKSTVDGKSC-IDIDECDT 571
            |.   ||..:..  ||... ||.::..|::....|||    .|.||:    .|:.| :|.|||.:
  Rat   216 YE---GARCEQEVLECASA-PCVHNASCLDGFRSFRC----LCWPGF----SGERCEVDEDECAS 268

  Fly   572 GE-HNCGERQICRNRN---------------------GGFVCSCPIGHELKRSIGGASTCVDTNE 614
            .. ||.|.   |..|:                     .||:||||.|      ..|....||.||
  Rat   269 DPCHNGGR---CSQRSDPTLYGGVQAIFPGAFSFSQAAGFLCSCPPG------FAGDDCSVDVNE 324

  Fly   615 CALEQRVCPLNAQCFNTIGAYYCECKAGFQKKSDGNNSTQCFDIDECQVIPGLCQQKCLNFWGGY 679
            ||                                   |..|.:...||.:|           .|:
  Rat   325 CA-----------------------------------SEPCLNGGSCQDLP-----------NGF 343

  Fly   680 RCTCNSGYQLGPDNRTC-NDINECEVHKDYKLCM--GLCINTPGSYQCSCPRGYILAADMNTCRD 741
            :|.|..||    ...|| .|.:||:...    |:  |.|.:|...|.|.||..:
  Rat   344 QCYCQDGY----TGLTCQEDTDECQSEP----CLHGGTCSDTVAGYICQCPEAW----------- 389

  Fly   742 VDECATDSINQVCTGRNDICTNIRGSYKCTTVNCPLGYSIDPEQKN-------RCRQNL--NFCE 797
                          |.:|....:.|   |....|||..:..|..|:       ||....  :||:
  Rat   390 --------------GGHDCSVQLTG---CQGHACPLAATCIPTFKSGFHSYICRCLPGTYGSFCD 437

  Fly   798 GEECYTQPSAFTYNFITFVSKLMIPPDGRTI-FTLR-------GPL-----WYDNIEFDLKIVRI 849
            ...        |::.::..|...:.|.|.:: |.||       |.|     ..|::|..|....:
  Rat   438 QNT--------TFSVVSGSSVWGLVPAGASLAFALRFRTTLLAGALATLKDSRDSLELVLVGAML 494

  Fly   850 QAT 852
            |||
  Rat   495 QAT 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31999	NP_001284712.1	vWFA	<189..227	CDD:294047	6/31 (19%)
		EGF_CA	251..293	CDD:238011	9/50 (18%)
		EGF_CA	328..>363	CDD:214542	12/34 (35%)
		EGF_CA	519..564	CDD:214542	13/47 (28%)
		EGF_CA	565..601	CDD:238011	16/57 (28%)
		EGF_CA	611..651	CDD:284955	5/39 (13%)
		vWFA	<655..695	CDD:294047	9/39 (23%)
		cEGF	678..701	CDD:289433	8/23 (35%)
		EGF_CA	698..>730	CDD:214542	11/33 (33%)
		cEGF	721..744	CDD:289433	4/22 (18%)
Crb2	NP_001129233.1	EGF_CA	<76..107	CDD:238011	9/57 (16%)
		EGF_CA	109..145	CDD:238011	14/43 (33%)
		EGF_CA	148..183	CDD:238011	13/44 (30%)
		EGF_CA	185..222	CDD:238011	15/97 (15%)
		EGF_CA	227..260	CDD:238011	12/41 (29%)
		EGF_CA	321..357	CDD:238011	16/85 (19%)
		EGF_CA	359..394	CDD:238011	12/63 (19%)
		Laminin_G_2	466..589	CDD:280389	8/32 (25%)
		EGF_CA	<614..642	CDD:238011
		LamG	657..774	CDD:238058
		EGF_CA	814..843	CDD:238011
		LamG	901..1021	CDD:304605
		EGF_CA	1176..1207	CDD:238011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910