DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31999 and yl

DIOPT Version :9

Sequence 1:	NP_001284712.1	Gene:	CG31999 / 43777	FlyBaseID:	FBgn0051999	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_996433.1	Gene:	yl / 32367	FlyBaseID:	FBgn0004649	Length:	1984	Species:	Drosophila melanogaster

Alignment Length:	835	Identity:	184/835 - (22%)
Similarity:	275/835 - (32%)	Gaps:	288/835 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 CGKIENLCAHIC--ENTFDAYQCKCHPGFML-DNNNVTC-SPMKTQI-CPSGYNLDKLDNKCIDI 252
            |.:....|:|||  |..:.:. |.|..||:. |..|.|| ..:..:. |.||
  Fly   988 CQQQNGGCSHICVGEGPYHSI-CLCPAGFVYRDAGNRTCVEALDCEFRCHSG------------- 1038

  Fly   253 DECREDLHDCKSSQYCHNTNGGYHCLNVKEKE----CPPGFHYDHDYDACKDDYKCKDRKCVKIQ 313
             ||....|.|...:.|.:.:...:|.....::    |.|.....|..:.|.|    |:|:|...:
  Fly  1039 -ECLTMNHRCNGRRDCVDNSDEMNCDEEHRRKPKVLCSPNQFACHSGEQCVD----KERRCDNRK 1098

  Fly   314 SC-DKGFSLHNGTCSDIDECSHKSLNNCHVNSNQECVNTVGSYSCNCLPGFNLDATLNKCVDINE 377
            .| |.....|   |...|:.     ..|||:.:            .|..|..:|::| .|...|:
  Fly  1099 DCHDHSDEQH---CEKFDKS-----KKCHVHQH------------GCDNGKCVDSSL-VCDGTND 1142

  Fly   378 CSINNHN--CLPTQRCDNTIGSYICTRLQSCGTGYTLNAETGNCDDDDECTLSTHNCPSNYDCHN 440
            |..|:..  |..|.||:.  |.:      .||:|              .|...:..|....||
  Fly  1143 CGDNSDELLCEATSRCEP--GMF------QCGSG--------------SCIAGSWECDGRIDC-- 1183

  Fly   441 TRGSFRCYRKISTMLTTRTTSTTVPPLSLENARRSFTSRYPYPLAVHPEYSQNNDSISTNRRVDC 505
                                                              |..:|.........|
  Fly  1184 --------------------------------------------------SDGSDEHDKCVHRSC 1198

  Fly   506 SPGFYRNTLGACIDT-------NECMEQNP---CGNHERCIN---TNGHFRCESLLQ-CSPGYKS 556
            .|...|..||.|:|.       |:|.:::.   ||.....:|   ....::|.|.|: |.|   |
  Fly  1199 PPDMQRCLLGQCLDRSLVCDGHNDCGDKSDELNCGTDSSTMNISCAEDQYQCTSNLKICLP---S 1260

  Fly   557 TVDGKSCIDIDECDTGEH--NCGERQICRNRNGGFVCSCPIGHELKRSIGGASTCVDTNECALEQ 619
            ||   .|....||..||.  :||:           |||.   :|.|        |....||...:
  Fly  1261 TV---RCNGTTECPRGEDEADCGD-----------VCSI---YEFK--------CRSGRECIRRE 1300

  Fly   620 RVCPLNAQCFNTIGAYYCECKAGFQKKS--------------------DG---------NNSTQC 655
            ..|.....|.:......||.:.|...:|                    ||         ||...|
  Fly  1301 FRCDGQKDCGDGSDELSCELEKGHHNQSQIQPWSTSSRSCRPHLFDCQDGECVDLSRVCNNFPDC 1365

  Fly   656 FD-IDE-------CQVIPG--LCQQKCLNFWGGYRCTCNSGYQLGPDNRTCNDINECEVHKDYKL 710
            .: .||       |:...|  :||.||.....|..|:|..||:|..|.::|.||:||:   :.:.
  Fly  1366 TNGHDEGPKCATACRSASGRQVCQHKCRATPAGAVCSCFDGYRLDADQKSCLDIDECQ---EQQP 1427

  Fly   711 CMGLCINTPGSYQCSCPRGYILAADMNTCRDVDECAT---DSINQVCTGRN----DICTNIRGSY 768
            |..||.||.|.|||.|...::|..|..:|:.:...||   .|.|:|   ||    .:..|:..|.
  Fly  1428 CAQLCENTLGGYQCQCHADFMLRQDRVSCKSLQSGATLLFSSFNEV---RNLSEQPVMLNVAWSA 1489

  Fly   769 KCTTV-------NCPLG----------YSIDPEQKNRCRQ---------NLNFCEGEECYTQPSA 807
            ..:.:       :..:|          |.||.:.|...|.         ::::..| ..|....|
  Fly  1490 NDSRITGFDLAMHRQMGYFSAEDEGIVYQIDLQTKVIVRALGLPAPTKLSVDWVTG-NVYVLSGA 1553

  Fly   808 FTYNFITFVSKLMIPPDGRTIFTLRGPLWYDNIEFDLKIVRI-----------QATTNIQKA-TD 860
            ......:||.::.    || |..::.|....::..|....||           |.::.|..| .|
  Fly  1554 QEIQACSFVGRMC----GR-IVHVKSPRHVKHLAVDGYHARIFYIVIRTEGYGQTSSEIHMARLD 1613

  Fly   861 GSFDTLQNNNQVNVILKKSLEGPQDIELELSMTVYTNGMPRGKSVAKLFLFVSQH 915
            ||        :.:::|::|         |..||..|....:     :|..||.||
  Fly  1614 GS--------RRDMLLQRS---------ESFMTALTTDPHQ-----QLLYFVDQH 1646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31999	NP_001284712.1	vWFA	<189..227	CDD:294047	12/36 (33%)
		EGF_CA	251..293	CDD:238011	8/45 (18%)
		EGF_CA	328..>363	CDD:214542	5/34 (15%)
		EGF_CA	519..564	CDD:214542	14/58 (24%)
		EGF_CA	565..601	CDD:238011	10/37 (27%)
		EGF_CA	611..651	CDD:284955	10/68 (15%)
		vWFA	<655..695	CDD:294047	16/49 (33%)
		cEGF	678..701	CDD:289433	10/22 (45%)
		EGF_CA	698..>730	CDD:214542	14/31 (45%)
		cEGF	721..744	CDD:289433	7/22 (32%)
yl	NP_996433.1	LDLa	90..124	CDD:238060
		LDLa	131..166	CDD:238060
		LDLa	184..216	CDD:238060
		LDLa	227..262	CDD:238060
		LDLa	271..302	CDD:238060
		FXa_inhibition	352..387	CDD:291342
		Ldl_recept_b	442..482	CDD:278487
		LY	466..508	CDD:214531
		Ldl_recept_b	529..569	CDD:278487
		LY	553..595	CDD:214531
		LY	596..637	CDD:214531
		FXa_inhibition	669..700	CDD:291342
		LY	774..815	CDD:214531
		LDLa	1032..1062	CDD:238060	8/43 (19%)
		LDLa	1074..1109	CDD:238060	11/41 (27%)
		LDLa	1118..1152	CDD:238060	11/46 (24%)
		LDLa	1157..1189	CDD:197566	11/105 (10%)
		LDLa	1198..1232	CDD:238060	9/33 (27%)
		LDLa	1243..1279	CDD:238060	13/41 (32%)
		LDLa	1283..1318	CDD:238060	9/45 (20%)
		LDLa	1340..1371	CDD:197566	5/30 (17%)
		FXa_inhibition	1388..1416	CDD:291342	11/27 (41%)
		EGF_CA	1418..1452	CDD:214542	15/36 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24034
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100