DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31999 and Fbln1

DIOPT Version :9

Sequence 1:	NP_001284712.1	Gene:	CG31999 / 43777	FlyBaseID:	FBgn0051999	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_001121019.1	Gene:	Fbln1 / 315191	RGDID:	1308667	Length:	705	Species:	Rattus norvegicus

Alignment Length:	951	Identity:	251/951 - (26%)
Similarity:	353/951 - (37%)	Gaps:	304/951 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LIVGGHVTTTMASDSISGYIRKCCINGLRHARTTASC--------KKIDIAPTIIPQLWLGLCHS 68
            |::.|.::...|..:....:..||..|.:.|.....|        |:               |..
  Rat    14 LLLLGSLSLLAARANADISMEACCTEGNQMANQHRDCSLSYTSESKE---------------CRM 63

  Fly    69 TLEVCCSRELDHQDCELGRLAALDGTRCDGEGNVTSS----SYATCCRSCQIGLAVKASKANCKD 129
            ..|.||..:|:...|..|...|.:...|....|..||    ....||..|.:|.|.:|....|:.
  Rat    64 VQEQCCHNQLEELHCATGINLASEPDGCASLHNYNSSLETIFIKRCCHCCMLGRAAQARGQTCEP 128

  Fly   130 PLFSFIFLIESYRACC---YGSADFKDQPGIDEIDKANSITDEGELPFVSEEDMNVTIVLTGDDD 191
            .|.........:||||   ..::||....|.|       :.|..::|...|::
  Rat   129 NLMISYQCGLVFRACCVKGQENSDFVRGDGTD-------LQDPAKIPEEEEQE------------ 174

  Fly   192 ICGKIENLCAHICENTFDAYQCKCHPGFMLDNNNVTCSPMKTQICPSGYNLDKLDNKCIDIDECR 256
                             |.|
  Rat   175 -----------------DPY--------------------------------------------- 177

  Fly   257 EDLHDCKSSQYCHNTNGGYHCLNVKEKECPPGFHYDHDYDACKDDYKCKDRKCVKIQSCDKGFSL 321
                                 ||                |.|:....||
  Rat   178 ---------------------LN----------------DRCRGGGPCK---------------- 189

  Fly   322 HNGTCSDIDECSHKSLNNCHVNSNQECVNTVGSYSCNCLPGFNLDATLNKCVDINECSINNHNCL 386
                                    |:|.:|.....|:|..|:.|.:....|.|||||...:|||.
  Rat   190 ------------------------QQCRDTGDEVICSCFVGYQLQSDGVSCEDINECITGSHNCR 230

  Fly   387 PTQRCDNTIGSYICTRLQSCGTGYTLNAETGNCDDDDECTLSTHNCPSNYDCHNTRGSFRCYRKI 451
            ..:.|.||:||:.|.|..||||||.| .|..||.|.|||....||||.::.|.||.|||||..|:
  Rat   231 LGESCINTVGSFRCQRDSSCGTGYEL-TEDNNCKDIDECETGIHNCPPDFICQNTLGSFRCRPKL 294

  Fly   452 STMLTTRTTSTTVPPLSLENARRSFTSRYPYPLAVHPEYSQNNDSISTNRRVDCSPGFYRNTLGA 516
                                                                .|..||.::.||.
  Rat   295 ----------------------------------------------------QCKSGFIQDALGN 307

  Fly   517 CIDTNECME-QNPCGNHERCINTNGHFRCE-SLLQCSPGYKSTVDGKSCIDIDECDTGEHNCGER 579
            |||.|||:. ..||...:.||||.|.:.|: ::..|..||....:|..|:|:|||......||:.
  Rat   308 CIDINECLSISAPCPVGQTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECSPPAEPCGKG 372

  Fly   580 QICRNRNGGFVCSCPIGHELKRSIGGASTCVDTNEC-ALEQRVCPLNAQCFNTIGAYYCECKAGF 643
            ..|.|..|.|.|.|..|:...   |.:.||||.||| ....|:|  ..:|.||.|:|:|.|.|||
  Rat   373 HHCLNSPGSFRCECKAGYYFD---GISRTCVDINECQRYPGRLC--GHKCENTPGSYHCSCSAGF 432

  Fly   644 QKKSDGNNSTQCFDIDECQVIPGLCQQKCLNFWGGYRCTCNSGYQLGP-DNRTCNDINECEVHKD 707
            :...||.:   |.|::||...|  |.|:|.|.:|.|:|.|..||||.. |..||.||:||.:...
  Rat   433 RLSVDGRS---CEDVNECLNSP--CSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTG 492

  Fly   708 YKLCMGLCINTPGSYQCSCP-RGYILAADMNTCRDVDECATDSINQVCTGRNDICTNIRGSYKCT 771
            ..:|...|||.|||:||||| .||.||.:...|:|:|||.|...|  |: .|:.|.||:||::|.
  Rat   493 GHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHN--CS-INETCFNIQGSFRCL 554

  Fly   772 TVNCPLGY--SIDP--EQKNRCRQNLNFCE--GEECYTQPSAFTYNFITFVSKLMIPPDGRTIFT 830
            :..||..|  |.|.  ::|....:.:..|.  .|.|...|       :..||..:|     ::.|
  Rat   555 SFECPENYRRSADTFRQEKTDTVRCIKSCRPTDEACMRDP-------VHTVSHTVI-----SLPT 607

  Fly   831 LRGPLWYDNIEFDL--KIVRIQATTNIQKA---------TDG----SFDTL---QNNNQVNVILK 877
            .|        ||..  :|:.::|.|.:..|         |:|    |||.:   ::...|.|:.:
  Rat   608 FR--------EFTRPEEIIFLRAVTPLYPANQADIIFDITEGNLRDSFDIIKRYEDGMTVGVVRQ 664

  Fly   878 -KSLEGPQDIELELSMTVYTNGMPRGKSVAKLFLFVSQHTF 917
             :.:.||....|:|.|.....|:...::|..:.:|||::.|
  Rat   665 VRPIVGPFYAVLKLEMNYVLGGVVSHRNVVNVHIFVSEYWF 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31999	NP_001284712.1	vWFA	<189..227	CDD:294047	2/37 (5%)
		EGF_CA	251..293	CDD:238011	2/41 (5%)
		EGF_CA	328..>363	CDD:214542	5/34 (15%)
		EGF_CA	519..564	CDD:214542	16/46 (35%)
		EGF_CA	565..601	CDD:238011	13/35 (37%)
		EGF_CA	611..651	CDD:284955	18/40 (45%)
		vWFA	<655..695	CDD:294047	18/40 (45%)
		cEGF	678..701	CDD:289433	12/23 (52%)
		EGF_CA	698..>730	CDD:214542	16/32 (50%)
		cEGF	721..744	CDD:289433	12/23 (52%)
Fbln1	NP_001121019.1	ANATO	30..85	CDD:237984	13/69 (19%)
		ANATO	107..162	CDD:237984	16/61 (26%)
		cEGF	201..221	CDD:289433	7/19 (37%)
		EGF_CA	218..261	CDD:284955	23/43 (53%)
		EGF_CA	264..>300	CDD:284955	18/87 (21%)
		EGF_CA	310..356	CDD:284955	16/45 (36%)
		EGF_CA	358..391	CDD:214542	13/32 (41%)
		cEGF	381..404	CDD:289433	9/25 (36%)
		cEGF	423..446	CDD:289433	10/25 (40%)
		cEGF	462..486	CDD:289433	12/23 (52%)
		vWFA	<481..524	CDD:294047	21/42 (50%)
		cEGF	506..530	CDD:289433	12/23 (52%)
		EGF_CA	527..567	CDD:284955	18/42 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I10871
eggNOG	1	0.900	-	-		E33208_3BC1W
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D106706at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45011
orthoMCL	1	0.900	-	-		OOG6_106295
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2629
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.720