DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31999 and fbln1

DIOPT Version :9

Sequence 1:	NP_001284712.1	Gene:	CG31999 / 43777	FlyBaseID:	FBgn0051999	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_571117.2	Gene:	fbln1 / 30240	ZFINID:	ZDB-GENE-990415-73	Length:	681	Species:	Danio rerio

Alignment Length:	954	Identity:	251/954 - (26%)
Similarity:	359/954 - (37%)	Gaps:	328/954 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 MCFLIVGGHVTTTMASDSISGYIRKCCINGLRHARTTASCKKIDIAPTIIPQLWLGLCHSTLEVC 73
            :|.|:.....|.|::.|:       ||.:|.:....:..|..:   |.|....   .|....|.|
Zfish    11 LCGLLRAQETTETISLDN-------CCEDGKKRGLESQDCSSL---PLISEST---TCRVVQEQC 62

  Fly    74 CSRELDHQDCELGRLAALDGTRCDG--EGNVTSSSYAT--CCRSCQIGLAVKASKANCKDPLFSF 134
            ||..|:...|..|...|.|.:.||.  .|:.|..:..|  ||..|.:|.|::....:|
Zfish    63 CSAVLEDSICTSGINMAKDQSSCDALLSGSSTCETKTTKMCCECCLLGRALQDQGLSC------- 120

  Fly   135 IFLIESYRACCYGSADFKDQPGIDEIDKANSITDEGELPFVSEEDMNVTIVLTGDDDICGKIENL 199
                                              |..||.|.:               ||::...
Zfish   121 ----------------------------------ELSLPVVYQ---------------CGQVSRS 136

  Fly   200 CAHICENTFDAYQCKCHPGFMLDNNNVTCSPMKTQICPSGYNLDKLDNKCIDIDECREDLHDCKS 264
            |                                                |:|    ::..|..:.
Zfish   137 C------------------------------------------------CVD----KQPAHGVQP 149

  Fly   265 SQYCHNTNGGYHCLNVKEKECPPGFHYDHDYDACKDDYKCKDRKCVKIQSCDKGFSLHNGTCSDI 329
            |:                            .||...:.:||...|.  |.|      .|||||
Zfish   150 SK----------------------------GDAQNTEDQCKAAGCA--QRC------LNGTCS-- 176

  Fly   330 DECSHKSLNNCHVNSNQECVNTVGSYSCNCLPGFNLDATLNKCVDINECSINNHNCLPTQRCDNT 394
                                         ||.||.|......|.|||||.:..|:|:..:||.||
Zfish   177 -----------------------------CLDGFKLKTDGKHCEDINECLLGPHHCVTGERCINT 212

  Fly   395 IGSYICTRLQSCGTGYTLNAETGNCDDDDECTLSTHNCPSNYDCHNTRGSFRCYRKISTMLTTRT 459
            :|||.|.|..||||||.| .:...|.|.|||.|.||||.:..:|.||.|||||
Zfish   213 LGSYRCQREISCGTGYEL-TDNNKCKDIDECDLGTHNCAAEMECQNTAGSFRC------------ 264

  Fly   460 TSTTVPPLSLENARRSFTSRYPYPLAVHPEYSQNNDSISTNRRVDCSPGFYRNTLGACIDTNECM 524
                                                    ..|:.|:.||.::.||:|||.|||:
Zfish   265 ----------------------------------------RPRMQCAAGFIQDALGSCIDINECV 289

  Fly   525 E-QNPCGNHERCINTNGHFRCE-SLLQCSPGYKSTVDGKSCIDIDECDTGEHNCGERQICRNRNG 587
            . ..||...:.|.||.|.|.|: ..:.|..||....:|..|:|||||...:::| :...|.|..|
Zfish   290 SVTGPCPGGQMCFNTVGSFICQRHSVTCGRGYHLNAEGTRCVDIDECAGPDNSC-DGHGCINLVG 353

  Fly   588 GFVCSCPIG---HELKRSIGGASTCVDTNECA-LEQRVCPLNAQCFNTIGAYYCECKAGFQKKSD 648
            .:.|.|..|   :.:.||      |.|.|||. ...|:|.  .:|.|.:|:|.|.|.|||:...|
Zfish   354 SYRCECRTGFIFNSISRS------CEDINECRNYPGRLCA--HKCENILGSYKCSCTAGFKLADD 410

  Fly   649 GNNSTQCFDIDECQVIPGLCQQKCLNFWGGYRCTCNSGYQLG-PDNRTCNDINECEVHKDYKLCM 712
            |.|   |.|::||:..|  |.|:|.|.:|.|:|.|..||||. .|..||.||:||.:.....:|.
Zfish   411 GRN---CDDVNECESSP--CSQECANVYGSYQCYCRRGYQLSDADGITCEDIDECALPTGGHICS 470

  Fly   713 GLCINTPGSYQCSCP-RGYILAADMNTCRDVDECATDSINQVCTGRNDICTNIRGSYKCTTVNCP 776
            ..|.|||||:.|:|| .||.|||:..:|:|:|||.|.:  ..|: .::.|.||:|.::|.:.:||
Zfish   471 YRCHNTPGSFHCTCPASGYTLAANGRSCQDIDECLTGT--HSCS-ESESCFNIQGGFRCLSFDCP 532

  Fly   777 LGY--------SIDPEQKNRCRQNLNFCEGEE--CYTQPSAFTYNFITFVSKLMIP-------PD 824
            ..|        .:|.....||   :..|:..:  |...|...|.:     :.:.:|       |:
Zfish   533 ANYRRSGDTRPRVDRADIIRC---VKSCQHNDISCVLNPILSTSH-----TAISLPTFREFNKPE 589

  Fly   825 GRTIFTLRGP------------LWYDNIEFDLKIVRIQATTNIQKATDGSFDTLQNNNQ---VNV 874
              .|..||.|            :.||.:|           .|||    .|||.::..:.   |.|
Zfish   590 --EIVFLRSPTPSHLPHMDSPEIVYDILE-----------GNIQ----NSFDIIKRLDHGMIVGV 637

  Fly   875 ILK-KSLEGPQDIELELSMTVYTNGMPRGKSVAKLFLFVSQHTF 917
            :.: |.|.||....|:|:|...|||:...:::..:.::||:..|
Zfish   638 VRQVKPLVGPVSTVLKLAMNYVTNGVVSHRNIINVHIYVSEFWF 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31999	NP_001284712.1	vWFA	<189..227	CDD:294047	3/37 (8%)
		EGF_CA	251..293	CDD:238011	3/41 (7%)
		EGF_CA	328..>363	CDD:214542	2/34 (6%)
		EGF_CA	519..564	CDD:214542	16/46 (35%)
		EGF_CA	565..601	CDD:238011	12/38 (32%)
		EGF_CA	611..651	CDD:284955	17/40 (43%)
		vWFA	<655..695	CDD:294047	18/40 (45%)
		cEGF	678..701	CDD:289433	12/23 (52%)
		EGF_CA	698..>730	CDD:214542	14/32 (44%)
		cEGF	721..744	CDD:289433	11/23 (48%)
fbln1	NP_571117.2	ANATO	19..72	CDD:294031	15/65 (23%)
		ANATO	99..>139	CDD:294031	14/143 (10%)
		cEGF	174..195	CDD:289433	11/51 (22%)
		EGF_CA	192..235	CDD:304395	23/43 (53%)
		EGF_CA	238..>265	CDD:284955	17/78 (22%)
		EGF_CA	284..331	CDD:214542	16/46 (35%)
		EGF_CA	332..>363	CDD:214542	11/31 (35%)
		cEGF	354..377	CDD:289433	7/28 (25%)
		cEGF	396..419	CDD:289433	11/25 (44%)
		cEGF	435..459	CDD:289433	12/23 (52%)
		cEGF	479..503	CDD:289433	11/23 (48%)
		EGF_CA	500..540	CDD:284955	14/42 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I11172
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D106706at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26619
orthoMCL	1	0.900	-	-		OOG6_106295
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2524
SonicParanoid	1	1.000	-	-		X2629
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.850