DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31999 and Fbln7

DIOPT Version :9

Sequence 1:	NP_001284712.1	Gene:	CG31999 / 43777	FlyBaseID:	FBgn0051999	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	XP_215832.6	Gene:	Fbln7 / 296145	RGDID:	1310131	Length:	439	Species:	Rattus norvegicus

Alignment Length:	511	Identity:	119/511 - (23%)
Similarity:	184/511 - (36%)	Gaps:	161/511 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   440 NTRGSFRCYRKISTMLTTRTTSTTVPPLSLENARRSFTSRYPYPLAVHPEYSQNNDSISTNRRVD 504
            |.:......:...:.:|......:.|.|......:.|.|:|.....||               ..
  Rat    57 NMKSRLTALQNTVSKMTPDAPPVSCPALDAPPNGKKFGSKYLVDHEVH---------------FT 106

  Fly   505 CSPGF---------------YRNTLGACIDTNECMEQNPCGNHERCINTNGHFRCESLLQCSPGY 554
            |:|||               :......|.||:||..| ||.|...|:....|:||    .|.||
  Rat   107 CNPGFQLVGPXSVVCLANGTWTGEQPRCRDTSECSSQ-PCHNGGTCVEGVHHYRC----ICPPG- 165

  Fly   555 KSTVDGKSCIDIDECDTGEHNCGERQICRNRNGGFVCSCPIGHELKRSIGGASTCVDTNECALEQ 619
                                ..|.|  |:::.   ..:.|.|      :.|.|.......||..:
  Rat   166 --------------------KTGNR--CQHQT---QAAAPGG------VAGDSAYSRAPRCAQVE 199

  Fly   620 RVCPLNAQCFNTIGAYYCECKAGFQKKSDGNNSTQCFDIDECQVIPGLCQQKCLNFWGGYRCTCN 684
            |             ..:|.|:|||......                           ||:
  Rat   200 R-------------EQHCSCEAGFHLSGTA---------------------------GGH----- 219

  Fly   685 SGYQLGPDNRTCNDINECEVHKDY---KLCMGLCINTPGSYQCSCPRGYILAADMNTCRDVDECA 746
                     ..|.|:||||::...   :|||..|:||||||:|:||.||.:.||..:|.||||||
  Rat   220 ---------SVCQDVNECEIYGQEGRPRLCMHACVNTPGSYRCTCPSGYRILADGKSCEDVDECA 275

  Fly   747 TDSINQVCTGRNDICTNIRGSYKCTTVNCPLG------YSIDPEQKNRCRQNLNFCEGEECYTQP 805
              ....:|. |...|.|..|.::|....||.|      ....|.|   |.:|....:...|...|
  Rat   276 --GPQHMCP-RGTTCINTGGGFQCVNPECPEGSGNISYVKTSPFQ---CERNPCPMDSRPCRHLP 334

  Fly   806 SAFTYNFITFVSKLMIPPDGRTIFTLR--------GPLWYDNIEFDLKIVRIQATTNIQKATDGS 862
            ...::::::..|.|..|   .|:|.:.        ||   :::.|.:          :...:.|.
  Rat   335 KTISFHYLSLPSNLKTP---ITLFRMATASVPGHPGP---NSLRFGI----------VGGNSRGH 383

  Fly   863 FDTLQNNNQV-NVILKKSLEGPQDIELELSMTVYTNGMPRGKSVAKLFLFVSQHTF 917
            |...:::.|. .:||.::|||||.:|:|:.|:.|.....:...|:|:.:|||::.|
  Rat   384 FVMQRSDRQTGELILIQTLEGPQTLEVEVDMSEYLERSFQASHVSKVTIFVSRYDF 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31999	NP_001284712.1	vWFA	<189..227	CDD:294047
		EGF_CA	251..293	CDD:238011
		EGF_CA	328..>363	CDD:214542
		EGF_CA	519..564	CDD:214542	15/44 (34%)
		EGF_CA	565..601	CDD:238011	5/35 (14%)
		EGF_CA	611..651	CDD:284955	8/39 (21%)
		vWFA	<655..695	CDD:294047	2/39 (5%)
		cEGF	678..701	CDD:289433	3/22 (14%)
		EGF_CA	698..>730	CDD:214542	18/34 (53%)
		cEGF	721..744	CDD:289433	12/22 (55%)
Fbln7	XP_215832.6	CCP	81..135	CDD:153056	11/68 (16%)
		EGF_CA	136..172	CDD:238011	17/63 (27%)
		vWFA	<220..267	CDD:412136	23/46 (50%)
		cEGF	250..273	CDD:403760	12/22 (55%)
		EGF_CA	270..307	CDD:311536	15/39 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002570
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910