DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31999 and Ltbp4

DIOPT Version :9

Sequence 1:	NP_001284712.1	Gene:	CG31999 / 43777	FlyBaseID:	FBgn0051999	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_001163807.1	Gene:	Ltbp4 / 292734	RGDID:	1307033	Length:	1631	Species:	Rattus norvegicus

Alignment Length:	906	Identity:	236/906 - (26%)
Similarity:	334/906 - (36%)	Gaps:	288/906 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 GLCHSTLEVCCSRELDHQDCELGRLAALDGTRCD-GEGNVTSSSYATCCRSCQIGLAVKASKANC 127
            |||.:..|......:|..:|       ..|.||. ||...|...| ||.  |..|..:.:|:::|
  Rat   342 GLCPTGFERVNGSCVDVDEC-------ATGGRCQHGECANTRGGY-TCV--CPDGFLLDSSRSSC 396

  Fly   128 ---------KDPLF--------SFIFL--IESYRACC----------------YGSADFK----- 152
                     |.|.:        |...|  |.....||                |||..|:
  Rat   397 ISQHVISEAKGPCYRVLQDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPYGSEGFREICPA 461

  Fly   153 --------------------DQPGID-EIDKANSIT-----------------DEGELPFV---- 175
                                |.|.:. ...:|..:|                 |.|..|.:
  Rat   462 GPGYHYSASDLRYNTRPLNPDPPRVTFNQPRAPPVTLRPPTGFLPTRRPEPRPDPGPQPELRPRP 526

  Fly   176 -----SEEDMNVTIVLTGDD--------DICGKIENLCA-HICENTFDAYQCKCHPGFMLDNNN- 225
                 .|..:......||.:        .:|.:...:|. ..|.:....|.|.|.|||.|....
  Rat   527 EPQPRPEFPLPSIPAWTGPEIPESGTSSSMCQRNPQVCGPGRCVSRPGGYTCACDPGFRLGPQGT 591

  Fly   226 ------------VTCSPMKTQ--------ICPSGYNLDKLDNKCIDIDECR-------------- 256
                        ..|:|.:.:        :|.:|:.......:|:|:||||
  Rat   592 RCIDVDECRRVPTPCAPGRCENTPGSFRCVCGTGFRAGPRATECLDVDECRRVPPPCDRGRCENT 656

  Fly   257 ---------------------EDLHDCKSSQ------YCHNTNGGYHCLNVKEKECPPGF---HY 291
                                 :|:.:|..|.      .|.|..|.:.|:      ||.||   ..
  Rat   657 PGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGACENLPGSFRCV------CPAGFLGSAC 715

  Fly   292 DHDYDAC-KDDYKCKDRKCVKIQ-----SCDKGFSLH--NGTCSDIDECSHKSLNNCHVNSNQEC 348
            :.|.|.| :....|...:|....     :|..||...  ...|.|:|||: :|.:.|   :...|
  Rat   716 EEDVDECAQQPPPCGPGRCDNTLGSFHCACPAGFRSRGPGAPCQDVDECA-RSPSPC---AYGRC 776

  Fly   349 VNTVGSYSCNCLPGFNLDATLNKCVDINECSINNHNCLPTQRCDNTIGSYICTRLQSCGTGYTLN 413
            .||.||:.|.|..||..:|..::|.|::||  .||...|.|.|.|:.||:.|   ::|..||.|:
  Rat   777 ENTEGSFKCVCPTGFQPNAAGSECEDVDEC--ENHLACPGQECVNSPGSFQC---RACPVGYHLH 836

  Fly   414 AETGNCDDDDECTLSTHNCPSNYDCHNTRGSFRCYRKISTMLTTRTTSTTVPPLSLENARRSFTS 478
              .|.|.|.|||...| .|..:..|.|.:|||.|
  Rat   837 --RGRCTDVDECNSGT-PCGLHGQCTNAQGSFHC------------------------------- 867

  Fly   479 RYPYPLAVHPEYSQNNDSISTNRRVDCSPGFYR---NTLGACIDTNECMEQNPCGNHERCINTNG 540
                                     .||.| ||   ...|.|.|.|||:|.:.|..|..|:||:|
  Rat   868 -------------------------SCSTG-YRAPSGRPGPCADINECLEGDFCFPHGECLNTDG 906

  Fly   541 HFRCESLLQCSPGYKSTVDGKSCIDIDECDTGEHNCGERQICRNRNGGFVCSCPIGHELKRSIGG 605
            .|.|    .|:|||:....|.||:|:|||  .|.:..:..||.|.:|.|.|.||.||   |:...
  Rat   907 SFTC----TCAPGYRPGPRGASCLDVDEC--SEEDLCQSGICTNTDGSFECICPPGH---RAGPD 962

  Fly   606 ASTCVDTNECALEQRVCPLNAQCFNTIGAYYC--ECKAGFQKKSDGNNSTQCFDIDECQVI-PGL 667
            .::|:|.:||.........:.:|.|:.|:|.|  :|..|:....:|.    |.|:|||:.. ..:
  Rat   963 LASCLDIDECRERGPALCGSQRCENSPGSYRCVRDCDPGYHPGPEGT----CDDVDECREYGSAI 1023

  Fly   668 C-QQKCLNFWGGYRCT--CNSGYQLGPDNRTCNDINECEVHKDYKLCMGLCINTPGSYQCSCPRG 729
            | .|:|.|..|.||||  |:.|||..|.. .|.|::||. ::.:.....:|.|.|||:||.|.:|
  Rat  1024 CGAQRCENTPGSYRCTPACDPGYQPTPGG-GCQDVDECR-NRSFCGAHAMCQNLPGSFQCVCDQG 1086

  Fly   730 YILAADMNTCRDVDECATDSINQVCTGRNDICTNIRGSYKCTTVNCPLG-YSIDPEQKNRC 789
            |..|.|...|.||:||.|  :..||  .:.:|.|:.||:.|.   ||.. ...|| ...||
  Rat  1087 YEGARDGRHCVDVNECET--LQGVC--GSALCENVEGSFLCV---CPTSPEEFDP-MTGRC 1139

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31999	NP_001284712.1	vWFA	<189..227	CDD:294047	10/59 (17%)
		EGF_CA	251..293	CDD:238011	16/85 (19%)
		EGF_CA	328..>363	CDD:214542	13/34 (38%)
		EGF_CA	519..564	CDD:214542	19/44 (43%)
		EGF_CA	565..601	CDD:238011	15/35 (43%)
		EGF_CA	611..651	CDD:284955	11/41 (27%)
		vWFA	<655..695	CDD:294047	19/43 (44%)
		cEGF	678..701	CDD:289433	11/24 (46%)
		EGF_CA	698..>730	CDD:214542	11/31 (35%)
		cEGF	721..744	CDD:289433	11/22 (50%)
Ltbp4	NP_001163807.1	EGF_CA	357..>387	CDD:214542	12/39 (31%)
		TB	418..453	CDD:279073	7/34 (21%)
		cEGF	575..598	CDD:289433	7/22 (32%)
		EGF_CA	595..631	CDD:214542	4/35 (11%)
		EGF_CA	637..678	CDD:214542	5/40 (13%)
		EGF_CA	679..716	CDD:238011	11/42 (26%)
		EGF_CA	718..752	CDD:214542	8/33 (24%)
		EGF_CA	760..800	CDD:284955	16/43 (37%)
		EGF_CA	842..874	CDD:238011	15/89 (17%)
		EGF_CA	885..921	CDD:214542	17/39 (44%)
		EGF_CA	927..962	CDD:214542	16/39 (41%)
		EGF_CA	968..1006	CDD:214542	10/37 (27%)
		EGF_CA	1056..1097	CDD:214542	15/41 (37%)
		TB	1200..1237	CDD:279073
		EGF_CA	1303..>1332	CDD:238011
		TB	1368..1404	CDD:279073
		EGF_CA	1581..>1615	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910