DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31999 and Fbln5

DIOPT Version :9

Sequence 1:	NP_001284712.1	Gene:	CG31999 / 43777	FlyBaseID:	FBgn0051999	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	XP_006240521.1	Gene:	Fbln5 / 29158	RGDID:	2594	Length:	461	Species:	Rattus norvegicus

Alignment Length:	539	Identity:	158/539 - (29%)
Similarity:	225/539 - (41%)	Gaps:	140/539 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   404 QSCGTGYTLNAETGNCDDDDECTLSTHNCPSNYDCHNTRGSFRCYRKISTMLTTRTTSTTVPPLS 468
            |.|..|:.|:.:||.|.|.|||......|..:..|.|..|.:.|        ..||......|.|
  Rat    38 QQCTNGFDLDRQTGQCLDIDECRTIPEACRGDMMCVNQNGGYLC--------IPRTNPVYRGPYS 94

  Fly   469 LENARRSFTSRY--PYPLAVHPEYSQNNDSISTNRRVDCSPGFYRNTLGACIDTNECMEQNPCGN 531
                 ..:::.|  |||.|..|..:.|..:||                            .|
  Rat    95 -----NPYSTSYSGPYPAAAPPVPASNYPTIS----------------------------RP--- 123

  Fly   532 HERCINTNGHFRCESLLQCSPGYKSTVDGKSCIDIDECDTGEHNCGERQICRNRNGGFVCSCPIG 596
                            |.|..||:.. :|..|:|:|||.|..|.|...|||.|..||:.|||..|
  Rat   124 ----------------LVCRFGYQMD-EGNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDG 171

  Fly   597 HELKRSIGGASTCVDTNECALEQRVCPLNAQCFNTIGAYYCECKAGFQKKSDGNNSTQCFDIDEC 661
            :.|..     ..|:|.:||    |.......|.|..|:|.|.|..||....||.:   |.|::||
  Rat   172 YWLLE-----GQCLDIDEC----RYGYCQQLCANVPGSYSCTCNPGFTLNDDGRS---CQDVNEC 224

  Fly   662 QVIPGLCQQKCLNFWGGYRCTCNSGYQLGPDNRTCNDINECEVHKDYKLCMGLCINTPGSYQCSC 726
            :. ...|.|.|:|.:|.:.|.|:.||:|..|...|:|::||...:  .||...|:|.||||.|||
  Rat   225 ET-ENPCVQTCVNTYGSFICRCDPGYELEEDGIHCSDMDECSFSE--FLCQHECVNQPGSYFCSC 286

  Fly   727 PRGYILAADMNTCRDVDECATDSINQVCTGRNDICTNIRGSYKCTTVNCPLGYSIDP---EQ--- 785
            |.||:|..|..:|:|::||  :..|..||.. ..|.|::|.:||          |||   |:
  Rat   287 PPGYVLLEDNRSCQDINEC--EHRNHTCTPL-QTCYNLQGGFKC----------IDPIVCEEPYL 338

  Fly   786 ---KNRCRQNLNFCEGEE--CYTQPSAFTYNFITFVSKLMIPPDGRTIFTLRGPLWYDNIEFDLK 845
               .|||     .|..|.  |..||....:..:..||...:|.|
  Rat   339 LIGDNRC-----MCPAENTGCRDQPFTILFRDMDVVSGRSVPAD--------------------- 377

  Fly   846 IVRIQATT---------NIQKATDGSFDTLQNNNQVN--VILKKSLEGPQDIELELSM-TVYTNG 898
            |.::||||         .|:...:|....::....::  :::.:.::||:||:|:|.| ||.|..
  Rat   378 IFQMQATTRYPGAYYIFQIKSGNEGREFYMRQTGPISATLVMTRPIKGPRDIQLDLEMITVNTVI 442

  Fly   899 MPRGKSVAKLFLFVSQHTF 917
            ..||.||.:|.::|||:.|
  Rat   443 NFRGSSVIRLRIYVSQYPF 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31999	NP_001284712.1	vWFA	<189..227	CDD:294047
		EGF_CA	251..293	CDD:238011
		EGF_CA	328..>363	CDD:214542
		EGF_CA	519..564	CDD:214542	6/44 (14%)
		EGF_CA	565..601	CDD:238011	18/35 (51%)
		EGF_CA	611..651	CDD:284955	14/39 (36%)
		vWFA	<655..695	CDD:294047	15/39 (38%)
		cEGF	678..701	CDD:289433	8/22 (36%)
		EGF_CA	698..>730	CDD:214542	15/31 (48%)
		cEGF	721..744	CDD:289433	12/22 (55%)
Fbln5	XP_006240521.1	vWFA	<134..178	CDD:294047	20/48 (42%)
		cEGF	200..223	CDD:289433	9/25 (36%)
		EGF_CA	220..258	CDD:214542	14/38 (37%)
		FXa_inhibition	271..299	CDD:291342	15/27 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11382
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910