DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31999 and Jag2

DIOPT Version :9

Sequence 1:	NP_001284712.1	Gene:	CG31999 / 43777	FlyBaseID:	FBgn0051999	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	XP_038967750.1	Gene:	Jag2 / 29147	RGDID:	2938	Length:	1247	Species:	Rattus norvegicus

Alignment Length:	983	Identity:	217/983 - (22%)
Similarity:	330/983 - (33%)	Gaps:	349/983 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 LWLGLCHSTLEVCCSRELDHQDCELGRL-----AALDGTRCDGEGNVTSSSYATCCR-SCQIGLA 119
            |.|.||     |..:|.:.:.:.:|..|     ..|.|..|||:|..|.:  ..|.| .|...:.
  Rat    15 LLLVLC-----VQATRPMGYFELQLSALRNVNGELLSGACCDGDGRTTRA--GGCGRDECDTYVR 72

  Fly   120 VKASKANCKDPLFSFIFLIESYRA-------CCY--------GSADFKDQPGIDEIDKANSITDE 169
            |      |          ::.|:|       |.|        |...|...|.....|:|.:.:..
  Rat    73 V------C----------LKEYQAKVTPTGPCSYGYGATPVLGGNSFYLPPAGAAGDRARARSRT 121

  Fly   170 G--------ELPFVSEEDMNVTIVL---------TGDDDICGKIENL------------------ 199
            |        .:||......:.|:::         |.|:::.  ||.:
  Rat   122 GGHQDPGLVVIPFQFAWPRSFTLIVEAWDWDNDTTPDEELL--IERVSHAGMINPEDRWKSLHFS 184

  Fly   200 --CAHI-------CENTFDAYQCK--CHP------GFMLDN-NNVTC------SPMKTQICPSGY 240
              .||:       |:..:.:..|.  |.|      .:..|. .|..|      ...|..:|..|.
  Rat   185 GHVAHLELQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGC 249

  Fly   241 NLDKLDNKCIDIDECR-------------------------EDLH-DC----------KSSQYC- 268
            ||  |...|....|||                         |..| ||          |...||
  Rat   250 NL--LHGGCTVPGECRCSYGWQGKFCDECVPYPGCVHGSCVEPWHCDCETNWGGLLCDKDLNYCG 312

  Fly   269 -HN--TNGGYHCLNVKEKE----CPPGFHYDHDYDAC-KDDYKCKDRKCVKIQSCDK---GFSLH 322
             |:  .||| .|:|.:..:    ||.|:...:    | :.::.|....|....||.:   ||..|
  Rat   313 SHHPCVNGG-TCINAEPDQYLCACPDGYLGKN----CERAEHACASNPCANGGSCHEVLSGFECH 372

  Fly   323 ------NGTCS-DIDECSHKSL-----------------------NNCHVNSNQ----------E 347
                  ..||: |||||:....                       ..|.:::|:          .
  Rat   373 CPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFS 437

  Fly   348 CVNTVGSYSCNCLPGFNLDATLNKCVDINECSINNHNCLPTQRCDNTIGSYICTRLQSCGTGYTL 412
            |.|.:|.|.|:||||:.   ..|..::||:|   :..|.....|.:.:..|.|.    |..|:
  Rat   438 CKNLIGGYYCDCLPGWK---GANCHININDC---HGQCQHGGTCKDLVNGYQCV----CPRGF-- 490

  Fly   413 NAETGNCDDDDECTLSTHNCPSN-----YDCHNTRGSFRCY--RKISTMLTTRTTSTTVPPLSLE 470
                    ....|.|..:.|.|:     ..|.:....|||:  |.:|..|.........|...|
  Rat   491 --------GGRHCELEYYKCASSPCRRGGICEDLVDGFRCHCPRGLSGPLCEVDVDLCEPNPCL- 546

  Fly   471 NARRSFTSRYPYPLAVHPEYSQNNDSISTNRRVDCSPGFYRNTLGACIDTNEC-----------M 524
            |..|.:.....|..|...::...|.|:.   |..| ||      |||...:.|           .
  Rat   547 NGARCYNLEDDYYCACPEDFGGKNCSVP---RETC-PG------GACRVIDGCGFEAGSRAHGAA 601

  Fly   525 EQNPCGNHERCIN-TNGHFRCESLLQCSPGYKSTVDGKSCID-IDECDTGEHNCGERQICRNRNG 587
            ....||.|..|:: ..|:|.|    .|..|:..|.    |.: ||:|        ..|.|  |||
  Rat   602 PSGVCGPHGHCVSLPGGNFSC----ICDSGFTGTY----CHENIDDC--------MGQPC--RNG 648

  Fly   588 G--------FVCSCPIGHELKRSIGGASTCVDTNECALEQRVCPLNAQCFNTIGAYYCECKAGFQ 644
            |        |.|.||.|.|      |....::.|:|..:.  |....:|::.:..:||.|..|::
  Rat   649 GTCIDEVDSFRCFCPSGWE------GELCDINPNDCLPDP--CHSRGRCYDLVNDFYCVCDDGWK 705

  Fly   645 KKS--------DG---NNSTQCFDIDE---CQVIPG----LC---------QQKCLNFWGG---- 678
            .|:        |.   :|...|:|..:   |...||    .|         ...|:|  ||
  Rat   706 GKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCTIAKNSSCVPNPCVN--GGTCVG 768

  Fly   679 ----YRCTCNSGYQLGPDNRTC-NDINECEVHKDYKLCMGLCINTPGSYQCSCPRGYILAADMNT 738
                :.|.|..|:    :.||| ::.|:|.....|.  .|:|::....::|.|..|: ...|
  Rat   769 SGDSFSCICRDGW----EGRTCTHNTNDCNPLPCYN--GGICVDGVNWFRCECAPGF-AGPD--- 823

  Fly   739 CR-DVDECATDSINQVCTGRNDICTNIRGSYKCTTVNCPLGYSIDPEQKNRCRQNLNFCEGEECY 802
            || ::|||.:.......|     |.:....|:|   :||.|.| .|    ||::.:.|.  ..|:
  Rat   824 CRINIDECQSSPCAYGAT-----CVDEINGYRC---SCPPGRS-GP----RCQEVVIFT--RPCW 873

  Fly   803 TQPSAFTY 810
            ::..:|.:
  Rat   874 SRGVSFPH 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31999	NP_001284712.1	vWFA	<189..227	CDD:294047	11/73 (15%)
		EGF_CA	251..293	CDD:238011	19/85 (22%)
		EGF_CA	328..>363	CDD:214542	15/67 (22%)
		EGF_CA	519..564	CDD:214542	11/56 (20%)
		EGF_CA	565..601	CDD:238011	15/44 (34%)
		EGF_CA	611..651	CDD:284955	10/50 (20%)
		vWFA	<655..695	CDD:294047	13/63 (21%)
		cEGF	678..701	CDD:289433	7/31 (23%)
		EGF_CA	698..>730	CDD:214542	7/31 (23%)
		cEGF	721..744	CDD:289433	6/23 (26%)
Jag2	XP_038967750.1	MNNL	28..103	CDD:400141	19/92 (21%)
		DSL	178..240	CDD:396134	9/61 (15%)
		EGF_CA	307..345	CDD:238011	11/42 (26%)
		EGF	351..381	CDD:394967	7/29 (24%)
		EGF_CA	385..421	CDD:238011	5/35 (14%)
		EGF_CA	423..458	CDD:238011	10/37 (27%)
		EGF_CA	461..496	CDD:238011	9/51 (18%)
		EGF_CA	502..534	CDD:238011	9/31 (29%)
		EGF_CA	536..571	CDD:238011	6/35 (17%)
		EGF_CA	636..671	CDD:238011	16/50 (32%)
		EGF_CA	676..709	CDD:238011	9/34 (26%)
		EGF	716..746	CDD:394967	7/29 (24%)
		EGF_CA	757..787	CDD:238011	9/35 (26%)
		EGF_CA	<797..824	CDD:238011	7/32 (22%)
		EGF_CA	827..863	CDD:238011	13/48 (27%)
		VWC_out	872..943	CDD:214565	2/10 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000