Protein Alignment CG31999 and Fbln2

DIOPT Version :10

• Sequence 1: NP_726551.2
• Gene: CG31999 / 43777
• FlyBaseID: FBgn0051999
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: NP_001093960.1
• Gene: Fbln2 / 282583
• RGDID: 628685
• Length: 1221
• Species: Rattus norvegicus
• Alignment Length: 939
• Identity: 293/939 - (31%)
• Similarity: 417/939 - (44%)
• Gaps: 203/939 - (21%)

  Fly    26 SISGYIRKCCINGLRHARTTASCKKIDIAPTIIPQ--LWLGLCHSTLEVCCSRELDHQDCELGRL 88
            |....:..||..|.:.|.....|::       ||:  ....:|......||...|..:.|..|.:
  Rat   427 STKDLVETCCAAGQQWAIDNDECQE-------IPENGAQSDVCRIAQRHCCISYLKEKSCVAGVM 484

  Fly    89 AALDGTRCDGEGNVTS--SSYATCCRSCQIGLAVKASKANCK-DPLF----SFIFLIESYRACCY 146
            .|.:|..|..|.|.|.  |.|..||..|.:||.|:|...:|: :|..    |.:.|     :||.
  Rat   485 GAKEGETCGAEDNDTCGVSLYKQCCDCCGLGLRVRAEGQSCESNPNLGYPCSHVML-----SCCE 544

  Fly   147 GSADF-------KDQPG-----IDEID----KANSITDEGELP-FVSEEDMNVTIVLTGDDDICG 194
            |....       ..:||     :.|.:    :|.|:..|.||| .:..:|.:..::|.|:
  Rat   545 GEEPLIVPEVRRPPEPGATPRRVSETEMGSREALSLGTEAELPNSLPGDDQDECLMLPGE----- 604

  Fly   195 KIENLCAHICENTFDAYQCKCHPGFMLDNNNVTCSPMKTQICPSGYNLDKLDNKCIDIDECREDL 259
                ||.|:|.||..:|:|.|.|||.|..:..||.|               |.....:|..||..
  Rat   605 ----LCQHLCINTVGSYRCACFPGFELQGDGRTCRP---------------DGGAPQLDTARESA 650

  Fly   260 HDCKSSQYCHNTNGGYHCLNVKEKECPPGFHYDHDYDACKDDYKCKDRKC-----VKIQSCDKGF 319
            ...:|:|...||..    |.|.:.            :.|||:..|: :.|     ..:.||..|:
  Rat   651 PRSESAQVSPNTIP----LPVPQP------------NTCKDNGPCR-QVCRVIGDTAMCSCFPGY 698

  Fly   320 SL--HNGTCSDIDECSHKSLNNCHVNS-NQECVNTVGSYSC-----NCLPGFNLDATLNKCVDIN 376
            ::  ...:|.|.|||    |...|..| .|.||||:||:.|     .|..|:.|:|. .||||||
  Rat   699 AIMADGVSCEDQDEC----LMGTHDCSWKQFCVNTLGSFYCVNHTVLCAEGYILNAH-RKCVDIN 758

  Fly   377 ECSINNHNCLPTQRCDNTIGSYICTRLQSCGTGYTLNAETGNCDDDDECTLSTHNCPSNYDCHNT 441
            ||..:.|.|...:.|.||.||:.|.:..:|..||.|.  .|.|.|.|||...||||.:.:.|.||
  Rat   759 ECVTDLHTCTRAEHCVNTPGSFQCYKALTCEPGYVLT--DGECTDVDECVTGTHNCQAGFSCQNT 821

  Fly   442 RGSFRCYRKISTMLTTRTTSTTVPPLSLENARRSFTSRYPYPLAVHPEYSQNNDSISTNRRVDCS 506
            :|||.|                                                    ..|..|.
  Rat   822 KGSFYC----------------------------------------------------QARQRCM 834

  Fly   507 PGFYRNTLGACIDTNECME-QNPCGNHERCINTNGHFRCE-SLLQCSPGYKSTVDGKSCIDIDEC 569
            .||.::..|.|:|.|||.. ..||.:...||||.|.:.|: :.|.|..||.:..:|..|:|::||
  Rat   835 DGFLQDPEGNCVDINECTSLLEPCRSGFSCINTVGSYTCQRNPLVCRRGYHANEEGSECVDVNEC 899

  Fly   570 DTGEHNCGERQICRNRNGGFVCSCPIGHELKRSIGGASTCVDTNECALEQ-RVCPLNAQCFNTIG 633
            :||.|.|||.|:|.|..|.:.|.|..|  .:|...| .||:|.|||.:.. |:|  ...|.||.|
  Rat   900 ETGVHRCGEGQLCYNLPGSYRCDCKPG--FQRDAFG-RTCIDVNECWISPGRLC--QHTCENTPG 959

  Fly   634 AYYCECKAGFQKKSDGNNSTQCFDIDECQVIPGLCQQKCLNFWGGYRCTCNSGYQLGPDNRTCND 698
            :|.|.|.|||...:||.:   |.|::||:.  ..|.|:|.|.:|.|:|.|..||||..|..||.|
  Rat   960 SYRCSCAAGFLLAADGKH---CEDVNECET--RRCSQECANIYGSYQCYCRQGYQLAEDGHTCTD 1019

  Fly   699 INECEVHKDYKLCMGLCINTPGSYQCSCP-RGYILAADMNTCRDVDECATDSINQVCTGRNDICT 762
            |:||...... ||...|:|.||||||:|| :||.:.|:..:|:|:||||..:.|  |: ..:.|.
  Rat  1020 IDECAQGAGI-LCTFRCVNVPGSYQCACPEQGYTMMANGRSCKDLDECALGTHN--CS-EAETCH 1080

  Fly   763 NIRGSYKCTTVNCPLGYSIDPEQKNRCRQNLNFCEG-EECYTQPSAFTYNFITFVSKLMIPPDGR 826
            ||:||::|...:||..|....|.|  |.:..  |:. .||.|.|:..|:..:.|.:.|::|..
  Rat  1081 NIQGSFRCLRFDCPPNYVRVSETK--CERTT--CQDISECQTSPARITHYQLNFQTGLLVPAH-- 1139

  Fly   827 TIFTLRGP---LWYDNIEFDLKIVRIQATTNIQKAT-DGSFDTLQNNNQVNVI-LKKSLEGPQDI 886
             ||.: ||   ...|.|           :..|.|.. :|.|.|.:.|....|: |::|:..|:|.
  Rat  1140 -IFRI-GPAPAFAGDTI-----------SLTITKGNEEGYFVTRRLNAYTGVVSLQRSVLEPRDF 1191

  Fly   887 ELELSMTVYTNGMPRGKSV----AKLFLF 911
            .|::.|.::..|     ||    ||:::|
  Rat  1192 ALDVEMKLWRQG-----SVTTFLAKMYIF 1215

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31999	NP_726551.2	vWFA	<189..227	CDD:469594	13/37 (35%)
		EGF_CA	251..293	CDD:238011	9/41 (22%)
		EGF_CA	328..>363	CDD:214542	16/40 (40%)
		EGF_CA	421..447	CDD:429571	14/25 (56%)
		EGF_CA	519..564	CDD:214542	17/46 (37%)
		EGF_CA	565..601	CDD:238011	16/35 (46%)
		EGF_CA	611..642	CDD:429571	13/31 (42%)
		FXa_inhibition	661..696	CDD:464251	14/34 (41%)
		EGF_CA	698..>730	CDD:214542	16/32 (50%)
		cEGF	723..744	CDD:463661	9/21 (43%)
Fbln2	NP_001093960.1	None