DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31999 and Egf

DIOPT Version :9

Sequence 1:	NP_001284712.1	Gene:	CG31999 / 43777	FlyBaseID:	FBgn0051999	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_036974.2	Gene:	Egf / 25313	RGDID:	2542	Length:	1132	Species:	Rattus norvegicus

Alignment Length:	741	Identity:	158/741 - (21%)
Similarity:	233/741 - (31%)	Gaps:	263/741 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 DAYQCKCHPGFML------DNNNVTCSPMKTQICPSGYNLDKLDNKCIDIDECREDLHDCKSSQY 267
            |:.:||...|..|      |.|:.:|:      |..||.|.:....|.|::||....|.|...
  Rat   315 DSERCKQRRGQCLYSLSERDPNSDSCA------CAEGYTLSRDRKYCEDVNECALQNHGCTLG-- 371

  Fly   268 CHNTNGGYHCLNVKEKECPPGFHYDHDYDACKDDYKCKDRK------CVKIQS-----CDKGFSL 321
            |.|..|.|:|      .||.||....|...|.:...|...:      |:....     |..|..|
  Rat   372 CENIPGSYYC------TCPTGFVLLPDGKRCHELVACPGNRSECSHDCILTSDGPLCICPAGSVL 430

  Fly   322 --HNGTCSDIDECSHKSLNNCHVNSNQECVN-TVGSYSCNCLPGFNLDATLNKC----------- 372
              ...||:.   ||......|    :|.|:. ::.|:.|:|.||::|......|
  Rat   431 GKDGKTCTG---CSSPDNGGC----SQICLPLSLASWECDCFPGYDLQLDRKSCAASGPQPFLLF 488

  Fly   373 ----------------------------------------------------------------- 372

  Rat   489 ANSQDIRHMHFDGTDYKTLLSRQMGMVFALDYDPVESKIYFAQTALKWIERANLDGSQRERLITE 553

  Fly   373 --------------------------VDINECSINNHNCLPTQRCDNTIGSYI---CTRLQSCGT 408
                                      ::.::.|..:|..:..:......|..:   ..||....|
  Rat   554 GVDTPEGLAVDWIGRRIYWTDSGKSVIEGSDLSGKHHQIIIKESISRPRGIAVHPKARRLFWTDT 618

  Fly   409 GYTLNAETGNCDDDDECTLSTHNC--PSNYDC-HNTRGSFRCYRKISTMLTTRTTSTTVPPLSLE 470
            |.:...|:.:....|...:::.|.  ||.... :.|...:.|..|:|          .:....|:
  Rat   619 GMSPRIESSSLQGSDRTLIASSNLLEPSGIAIDYLTDTLYWCDTKLS----------VIEMADLD 673

  Fly   471 NA-RRSFTSR---YPYPLAVHPEYSQNND-SISTNRRVDCSPGFYRNTL-GACIDTNECMEQNPC 529
            .: ||..|..   :|:.|||..::...:| :|.:..||:...|..|..| |:.:..:..:..:|.
  Rat   674 GSKRRRLTQNDVGHPFSLAVFEDHVWFSDWAIPSVIRVNKRTGQNRVRLRGSMLKPSSLVVVHPL 738

  Fly   530 G--NHERCINTNGHFRCESLLQ---------CSPGYKSTVDGKSCI------------------- 564
            .  ..:.|::.||  .||.:.|         |..|:....|||.|:
  Rat   739 AKPGADPCLHRNG--GCEHICQESLGTAQCLCREGFVKAPDGKMCLTRKDDQILAGDNADLSKEV 801

  Fly   565 ------------DID------------------ECDTGEHNCGERQICRNRNGGFVCSCPIGHEL 599
                        |.|                  |.|.|...||....|.:.....||.|     |
  Rat   802 ASLDNSPKAYVPDDDRTESSTLVAEIMVSGLNYEDDCGPGGCGSHAHCISEGEAAVCQC-----L 861

  Fly   600 KRSIGGASTCVDTNECALEQRVC-PLNAQCFNTIGAYYCECKAGFQKKSDGNNSTQCFDIDECQV 663
            |...|..:.|.|.:||.|....| |.:::|.||.|.|.|:|..|::  .||   ..|.|:||||.
  Rat   862 KGFAGDGNLCSDIDECELGSSDCPPTSSRCINTEGGYVCQCSEGYE--GDG---IYCLDVDECQQ 921

  Fly   664 IPGLCQQK--CLNFWGGYRCTC--------------NSGYQLGPDNRTC----NDINECEVHKD- 707
            ....|.:.  |.|..|||.|||              .|...||.|.  |    |.|..|....|
  Rat   922 GSHGCSENATCTNTEGGYNCTCAGCPSAPGLPCPDSTSPSLLGKDG--CHWVRNSITGCPPSYDG 984

  Fly   708 YKLCMGLC--INTPGSYQCSCPRGYI 731
            |.|..|:|  :.:...|.|:|..|||
  Rat   985 YCLNGGVCMYVESVDRYVCNCVIGYI 1010

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31999	NP_001284712.1	vWFA	<189..227	CDD:294047	7/23 (30%)
		EGF_CA	251..293	CDD:238011	14/41 (34%)
		EGF_CA	328..>363	CDD:214542	9/35 (26%)
		EGF_CA	519..564	CDD:214542	12/55 (22%)
		EGF_CA	565..601	CDD:238011	12/53 (23%)
		EGF_CA	611..651	CDD:284955	16/40 (40%)
		vWFA	<655..695	CDD:294047	19/55 (35%)
		cEGF	678..701	CDD:289433	12/40 (30%)
		EGF_CA	698..>730	CDD:214542	10/34 (29%)
		cEGF	721..744	CDD:289433	6/11 (55%)
Egf	NP_036974.2	LDL-receptor class B 1	87..128
		LDL-receptor class B 2	129..170
		LY	152..193	CDD:214531
		LDL-receptor class B 3	171..212
		LDL-receptor class B 4	213..259
		cEGF	339..360	CDD:403760	7/26 (27%)
		FXa_inhibition	361..396	CDD:405372	13/42 (31%)
		FXa_inhibition	402..437	CDD:405372	5/34 (15%)
		FXa_inhibition	444..477	CDD:405372	9/36 (25%)
		LDL-receptor class B 5	484..524		0/39 (0%)
		LY	505..547	CDD:214531	0/41 (0%)
		LDL-receptor class B 6	525..567		0/41 (0%)
		LY	548..590	CDD:214531	1/41 (2%)
		LDL-receptor class B 7	568..610		3/41 (7%)
		LY	591..634	CDD:214531	6/42 (14%)
		LDL-receptor class B 8	611..654		9/42 (21%)
		LY	634..677	CDD:214531	8/52 (15%)
		LDL-receptor class B 9	655..697		11/51 (22%)
		LY	678..719	CDD:214531	11/40 (28%)
		FXa_inhibition	746..781	CDD:405372	11/36 (31%)
		EGF_CA	839..871	CDD:419698	10/36 (28%)
		EGF_CA	873..913	CDD:214542	16/44 (36%)
		EGF_3	919..>943	CDD:403986	9/23 (39%)
		PHA03099	<974..>1016	CDD:165381	13/37 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1068..1096
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000