DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31999 and VWCE

DIOPT Version :9

Sequence 1:	NP_001284712.1	Gene:	CG31999 / 43777	FlyBaseID:	FBgn0051999	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_689931.2	Gene:	VWCE / 220001	HGNCID:	26487	Length:	955	Species:	Homo sapiens

Alignment Length:	898	Identity:	184/898 - (20%)
Similarity:	282/898 - (31%)	Gaps:	336/898 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 CGK----IENLCAHICENTFDAYQC-KCHP-----GFMLDNNNVTCSPMKTQICPSGYNLDK--L 245
            ||.    ..|:|:  |::......| :.|.     |..|..|:..|..: .::||.|:::.:  :
Human    75 CGSGICIAPNVCS--CQDGEQGATCPETHGPCGEYGCDLTCNHGGCQEV-ARVCPVGFSMTETAV 136

  Fly   246 DNKCIDIDECREDLHDCKSSQYCHNTNGGYHCLNVKEKECPPGFHYDHDYDACKDDYKCKDRKCV 310
            ..:|.|||||...  .|:.  :|.||.||:.|      ||.||.....|..:|:|..:|....|
Human   137 GIRCTDIDECVTS--SCEG--HCVNTEGGFVC------ECGPGMQLSADRHSCQDTDECLGTPC- 190

  Fly   311 KIQSCDKGFSLHNGTCSDIDECSHKSLNNCHVNSNQECVNTVGSYSCNCLPGFNLDATLNKCVDI 375
                                              .|.|.|::|||.|:|..||:|....:.|||:
Human   191 ----------------------------------QQRCKNSIGSYKCSCRTGFHLHGNRHSCVDV 221

  Fly   376 NECSINNHNCLPTQR------CDNTIGSYICTRLQSCGTGYTLNAETGNCDDDDECTLST----- 429
            |||.      .|.:|      |.||:||::||    |..|:.|.|:..:|:...:..|:.
Human   222 NECR------RPLERRVCHHSCHNTVGSFLCT----CRPGFRLRADRVSCEAFPKAVLAPSAILQ 276

  Fly   430 -----------------------HNCPSNYDCHNTRGSFRCYR------------------KIST 453
                                   |:.||.  ........|..|                  .:||
Human   277 PRQHPSKMLLLLPEAGRPALSPGHSPPSG--APGPPAGVRTTRLPSPTPRLPTSSPSAPVWLLST 339

  Fly   454 MLTTRTTSTTV-----PPLSLENARRSFTSRYPYP----LAVHPEYSQNNDSISTNRRVDCSPGF 509
            :|.|...:.::     ||..|:.......|....|    ||..|                 ||.:
Human   340 LLATPVPTASLLGNLRPPSLLQGEVMGTPSSPRGPESPRLAAGP-----------------SPCW 387

  Fly   510 YRNTLGACIDTNECMEQNPCGNHERCINTNGHFRCESLLQCSPGYKSTV---DGKSCIDIDECDT 571
            :   |||..::.....:..|   .:|...:|...||. ::|.......:   ||..|   ..| |
Human   388 H---LGAMHESRSRWTEPGC---SQCWCEDGKVTCEK-VRCEAACSHPIPSRDGGCC---PSC-T 441

  Fly   572 GEHNCGERQICRNRNGGF--------VCSCPIGHELKRSIGGASTCVDTNECALEQRVCPLNAQC 628
            |   |....:.|.....|        ||.|         :.|..:|: :.||.......|....|
Human   442 G---CFHSGVVRAEGDVFSPPNENCTVCVC---------LAGNVSCI-SPECPSGPCQTPPQTDC 493

  Fly   629 FNTI-------GAYYCECKAGFQKKSDGNNSTQCFDID---ECQVIPG---LCQQKCLNFWGGYR 680
            ...:       |.:|.:   |......|:..|.|...:   ||..:|.   .|.::......|..
Human   494 CTCVPVRCYFHGRWYAD---GAVFSGGGDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQC 555

  Fly   681 C-TC-----NSGYQLG------PDNRTCNDINECEVHKDYKLCMGLCI-NTPGSYQC-------S 725
            | ||     ::|..|.      |..:..:..:.||          ||| ...||..|       |
Human   556 CFTCQEPTPSTGCSLDDNGVEFPIGQIWSPGDPCE----------LCICQADGSVSCKRTDCVDS 610

  Fly   726 CPRGYILAADMNTCRDVDECATD-SINQVCTGR----NDI----------CTNIRGSYKCTTVNC 775
            ||         :..|...:|..| |.....|||    |:.          |..:.||..|:.|:|
Human   611 CP---------HPIRIPGQCCPDCSAGCTYTGRIFYNNETFPSVLDPCLSCICLLGSVACSPVDC 666

  Fly   776 PLG------------------------------YSIDPEQKNRCRQNLN--FCE----------- 797
            |:.                              :::|.|...||...|.  .||
Human   667 PITCTYPFHPDGECCPVCRDCNYEGRKVANGQVFTLDDEPCTRCTCQLGEVSCEKVPCQRACADP 731

  Fly   798 ----GEECYTQPSAFTYNFITFVSKLMIPPDGRTIFTLRGPLWYDNIEFD--------------- 843
                |:.|.:.|.:.:    ....|..:.|.|...|:..|...:.:.|..
Human   732 ALLPGDCCSSCPDSLS----PLEEKQGLSPHGNVAFSKAGRSLHGDTEAPVNCSSCPGPPTASPS 792

  Fly   844 ---LKIVRIQATTNIQKATDGSFDTLQNNNQVNVILKKSLEGPQDIELELSMT 893
               |.::::...||:.|.     .||..:       .....||..:.|.|:.|
Human   793 RPVLHLLQLLLRTNLMKT-----QTLPTS-------PAGAHGPHSLALGLTAT 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31999	NP_001284712.1	vWFA	<189..227	CDD:294047	10/43 (23%)
		EGF_CA	251..293	CDD:238011	16/41 (39%)
		EGF_CA	328..>363	CDD:214542	8/34 (24%)
		EGF_CA	519..564	CDD:214542	8/47 (17%)
		EGF_CA	565..601	CDD:238011	9/43 (21%)
		EGF_CA	611..651	CDD:284955	8/46 (17%)
		vWFA	<655..695	CDD:294047	12/57 (21%)
		cEGF	678..701	CDD:289433	7/34 (21%)
		EGF_CA	698..>730	CDD:214542	11/39 (28%)
		cEGF	721..744	CDD:289433	6/29 (21%)
VWCE	NP_689931.2	EGF_CA	142..180	CDD:214542	17/47 (36%)
		cEGF	200..223	CDD:315355	10/22 (45%)
		EGF_CA	220..262	CDD:214542	17/51 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..329		5/38 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	360..380		3/19 (16%)
		VWC	386..440	CDD:327433	12/63 (19%)
		VWC	501..559	CDD:327433	12/60 (20%)
		VWC	572..625	CDD:214564	14/71 (20%)
		VWC	629..684	CDD:327433	11/54 (20%)
		VWC	687..742	CDD:327433	9/54 (17%)
		Atrophin-1	<726..944	CDD:331285	20/124 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	812..889		7/29 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	903..955
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910