DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31999 and FBLN2

DIOPT Version :9

Sequence 1:	NP_001284712.1	Gene:	CG31999 / 43777	FlyBaseID:	FBgn0051999	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_001004019.1	Gene:	FBLN2 / 2199	HGNCID:	3601	Length:	1231	Species:	Homo sapiens

Alignment Length:	953	Identity:	287/953 - (30%)
Similarity:	410/953 - (43%)	Gaps:	221/953 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SISGYIRKCCINGLRHARTTASCKKIDIAPTIIPQLWLGLCHSTLEVCCSRELDHQDCELGRLAA 90
            |....|..||..|.:.|.....|.:|..:.|..     .:|.:....||...|..:.|..|.|.|
Human   437 STKDLIETCCAAGQQWAIDNDECLEIPESGTED-----NVCRTAQRHCCVSYLQEKSCMAGVLGA 496

  Fly    91 LDGTRCDGEGNVTS--SSYATCCRSCQIGLAVKASKANCK-DPLFSF----IFLIESYRACCYGS 148
            .:|..|..|.|.:.  |.|..||..|.:||.|:|...:|: :|...:    :.|     :||.|.
Human   497 KEGETCGAEDNDSCGISLYKQCCDCCGLGLRVRAEGQSCESNPNLGYPCNHVML-----SCCEGE 556

  Fly   149 ADF-------KDQPG-----IDEIDKAN----SITDEGELP-FVSEEDMNVTIVLTGDDDICGKI 196
            ...       ..:|.     :.|.:.|.    |:..|.||| .:..:|.:..::|.|:
Human   557 EPLIVPEVRRPPEPAAAPRRVSEAEMAGREALSLGTEAELPNSLPGDDQDECLLLPGE------- 614

  Fly   197 ENLCAHICENTFDAYQCKCHPGFMLDNNNVTCSP--------------MKTQICPSGYNLDKL-- 245
              ||.|:|.||..:|.|.|.|||.|.::..||.|              :|::......|...|
Human   615 --LCQHLCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALKSEFSQVASNTIPLPL 677

  Fly   246 --DNKCIDIDECREDLHDCKSSQYCHNTNGGYHCLNVKEKECPPGFHYDHDYDACKDDYKCKDRK 308
              .|.|.|...|:         |.|....|...|      .|.||      |....|...|:|:
Human   678 PQPNTCKDNGPCK---------QVCSTVGGSAIC------SCFPG------YAIMADGVSCEDQ- 720

  Fly   309 CVKIQSCDKGFSLHNGTCSDIDECSHKSLNNCH-VNSNQECVNTVGSYSC-----NCLPGFNLDA 367
                                 |||    |...| .:..|.||||:||:.|     .|..|:.|:|
Human   721 ---------------------DEC----LMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILNA 760

  Fly   368 TLNKCVDINECSINNHNCLPTQRCDNTIGSYICTRLQSCGTGYTLNAETGNCDDDDECTLSTHNC 432
            . .||||||||..:.|.|...:.|.||:||:.|.:..:|..||.|  :.|.|:|.|||.:.||.|
Human   761 H-RKCVDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGYAL--KDGECEDVDECAMGTHTC 822

  Fly   433 PSNYDCHNTRGSFRCYRKISTMLTTRTTSTTVPPLSLENARRSFTSRYPYPLAVHPEYSQNNDSI 497
            ...:.|.||:|||.|
Human   823 QPGFLCQNTKGSFYC-------------------------------------------------- 837

  Fly   498 STNRRVDCSPGFYRNTLGACIDTNECME-QNPCGNHERCINTNGHFRCE-SLLQCSPGYKSTVDG 560
              ..|..|..||.::..|.|:|.|||.. ..||.....||||.|.:.|: :.|.|:.||.::.||
Human   838 --QARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHASDDG 900

  Fly   561 KSCIDIDECDTGEHNCGERQICRNRNGGFVCSCPIGHELKRSIGGASTCVDTNEC-ALEQRVCPL 624
            ..|:|::||:||.|.|||.|:|.|..|.:.|.|..|  .:|...|.. |:|.||| |...|:|
Human   901 TKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAG--FQRDAFGRG-CIDVNECWASPGRLC-- 960

  Fly   625 NAQCFNTIGAYYCECKAGFQKKSDGNNSTQCFDIDECQVIPGLCQQKCLNFWGGYRCTCNSGYQL 689
            ...|.||:|:|.|.|.:||...:||.   :|.|::||:.  ..|.|:|.|.:|.|:|.|..||||
Human   961 QHTCENTLGSYRCSCASGFLLAADGK---RCEDVNECEA--QRCSQECANIYGSYQCYCRQGYQL 1020

  Fly   690 GPDNRTCNDINECEVHKDYKLCMGLCINTPGSYQCSCP-RGYILAADMNTCRDVDECATDSINQV 753
            ..|..||.||:||...... ||...|:|.||||||:|| :||.:.|:..:|:||||||..:.|
Human  1021 AEDGHTCTDIDECAQGAGI-LCTFRCLNVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHN-- 1082

  Fly   754 CTGRNDICTNIRGSYKCTTVNCPLGYSIDPEQKNRCRQNLNFC-EGEECYTQPSAFTYNFITFVS 817
            |: ..:.|.||:||::|....||..|.  ...|.:|.:..  | :..||...|:..|:..:.|.:
Human  1083 CS-EAETCHNIQGSFRCLRFECPPNYV--QVSKTKCERTT--CHDFLECQNSPARITHYQLNFQT 1142

  Fly   818 KLMIPPDGRTIFTLRGP---LWYDNIEFDLKIVRIQATTNIQKATDGSFDTLQNNNQVNVI-LKK 878
            .|::|..   ||.: ||   ...|.|..::          |:...:|.|.|.:.|....|: |::
Human  1143 GLLVPAH---IFRI-GPAPAFTGDTIALNI----------IKGNEEGYFGTRRLNAYTGVVYLQR 1193

  Fly   879 SLEGPQDIELELSMTVYTNGMPRGKSV----AKLFLFVSQHTF 917
            ::..|:|..|::.|.::..|     ||    ||:.:|.:  ||
Human  1194 AVLEPRDFALDVEMKLWRQG-----SVTTFLAKMHIFFT--TF 1229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31999	NP_001284712.1	vWFA	<189..227	CDD:294047	13/37 (35%)
		EGF_CA	251..293	CDD:238011	9/41 (22%)
		EGF_CA	328..>363	CDD:214542	14/40 (35%)
		EGF_CA	519..564	CDD:214542	18/46 (39%)
		EGF_CA	565..601	CDD:238011	16/35 (46%)
		EGF_CA	611..651	CDD:284955	18/40 (45%)
		vWFA	<655..695	CDD:294047	17/39 (44%)
		cEGF	678..701	CDD:289433	12/22 (55%)
		EGF_CA	698..>730	CDD:214542	16/32 (50%)
		cEGF	721..744	CDD:289433	12/23 (52%)
FBLN2	NP_001004019.1	ANATO	430..490	CDD:237984	13/57 (23%)
		ANATO	515..563	CDD:237984	14/52 (27%)
		FXa_inhibition	616..644	CDD:291342	12/27 (44%)
		vWFA	<717..759	CDD:294047	17/67 (25%)
		EGF_CA	766..>802	CDD:214542	14/35 (40%)
		EGF_CA	811..855	CDD:284955	19/95 (20%)
		EGF_CA	857..904	CDD:214542	18/46 (39%)
		EGF_CA	905..947	CDD:214542	18/44 (41%)
		vWFA	<946..986	CDD:294047	18/41 (44%)
		cEGF	970..993	CDD:289433	9/25 (36%)
		cEGF	1009..1032	CDD:289433	12/22 (55%)
		cEGF	1051..1075	CDD:289433	12/23 (52%)
		EGF_CA	1072..1120	CDD:284955	19/54 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	51	1.000	Domainoid score	I11591
eggNOG	1	0.900	-	-		E33208_3BC1W
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H1514
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D106706at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40871
orthoMCL	1	0.900	-	-		OOG6_106295
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2524
SonicParanoid	1	1.000	-	-		X2629
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.750