DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31999 and fbl-1

DIOPT Version :9

Sequence 1:	NP_001284712.1	Gene:	CG31999 / 43777	FlyBaseID:	FBgn0051999	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_001293878.1	Gene:	fbl-1 / 177788	WormBaseID:	WBGene00001403	Length:	751	Species:	Caenorhabditis elegans

Alignment Length:	938	Identity:	259/938 - (27%)
Similarity:	368/938 - (39%)	Gaps:	234/938 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 MCFLIVGGHVTTTMASDSISGYIRKCCINGLRHARTTASCKKIDIAPTIIPQLWLGLCHSTLEVC 73
            :|||::...|..|.|::     :.:||..|.||.:.:.:|..|....|.:      .|.....:|
Worm     3 ICFLLLAFLVAETFANE-----LTRCCAGGTRHFKNSNTCSSIKSEGTSM------TCQRAASIC 56

  Fly    74 CSRELDHQDCELGRLAALDGTRCDGEGNVTSSSY-ATCCRSCQIGLAVKASKANCKDPLFSFIFL 137
            |.|.|....|:.|...|.:...|....|:..... ..||..|.:...:......|..|:......
Worm    57 CLRSLLDNACDSGTDIAKEEESCPSNINILGGGLKKECCDCCLLAKDLLNRNEPCVAPVGFSAGC 121

  Fly   138 IESYRACCYGSADFKDQPGIDEIDKANSITDEGELPFVSEEDMNVTIVL-TGDDDICGKIENLCA 201
            :.|:..||.|..:               ||...|:  ::...:|...|| .||.  |.  .:.|.
Worm   122 LRSFNKCCNGDIE---------------ITHASEI--ITGRPLNDPHVLHLGDR--CA--SSHCE 165

  Fly   202 HIC-ENTFDAYQCKCHPGFMLDNNNVTCSPMKTQICPSGYNLDKLDNKCIDIDECREDLHDCKSS 265
            |:| :...:..:|.|..||              .:.|.|.       .|:|.:||......|..|
Worm   166 HLCHDRGGEKVECSCRSGF--------------DLAPDGM-------ACVDRNECLTRQSPCTQS 209

  Fly   266 QYCHNTNGGYHCLNVKEKECPPGFHYDHDYDACKDDYKCKDRKCVKIQSCDKGFSLHNGTCSDID 330
            :.|.||.|||.|.....:..|                                   |....:.|.
Worm   210 EDCVNTIGGYICQRRISRLVP-----------------------------------HRHRANRIG 239

  Fly   331 ECSHKSLNNCHVNSNQECVNTVGSYSCNCLPGFNLDATLNKCVDINECSINNHNCLPTQRCDNTI 395
            ....:..::.:..:.:....:..:....|..|:....  ..|||::||::.:|:|.|..:|.||.
Worm   240 NAPRRMRDDPYSRAGEYREASQANTEFGCPMGWLFQH--GHCVDVDECNLGSHDCGPLYQCRNTQ 302

  Fly   396 GSYICTRLQSCGTGYTLNAETGN----------------CDDDDECTLSTHNCPSNYDCHNTRGS 444
            |||.|. .:.||.|...|..||.                |:|.||| ::.|||.:..:|.||.||
Worm   303 GSYRCD-AKKCGDGELQNPMTGECTSITCPNGYYPKNGMCNDIDEC-VTGHNCGAGEECVNTPGS 365

  Fly   445 FRCYRKISTMLTTRTTSTTVPPLSLENARRSFTSRYPYPLAVHPEYSQNNDSISTNRRVDCSPGF 509
            |||.:|.:.                                                   |:.|:
Worm   366 FRCQQKGNL---------------------------------------------------CAHGY 379

  Fly   510 YRN-TLGACIDTNECMEQNPCGNHERCINTNGHFRCESLLQCSPGYKSTVDGKSCIDIDECDTGE 573
            ..| ..|.|.|.||| :|..||:.| |||..|.::|    :|.|||:.....|.|.|:|||..
Worm   380 EVNGATGFCEDVNEC-QQGVCGSME-CINLPGTYKC----KCGPGYEFNDAKKRCEDVDECIK-- 436

  Fly   574 HNCGERQICRNRNGGFVCSCPIGHELKRSIGGASTCVDTNECALEQRVCPLNAQCFNTIGAYYCE 638
                           |.     ||                       ||.|:|:|.||||::.|:
Worm   437 ---------------FA-----GH-----------------------VCDLSAECINTIGSFECK 458

  Fly   639 CKAGFQKKSDGNNSTQCFDIDECQVIPGLCQQKCLNFWGGYRCTCNSGYQLGPDNRTCNDINECE 703
            ||.|||..|||.   :|.|::||......|:|||:|..|.|:|.|:.|:.||||...|.||:||.
Worm   459 CKPGFQLASDGR---RCEDVNECTTGIAACEQKCVNIPGSYQCICDRGFALGPDGTKCEDIDECS 520

  Fly   704 V--HKDYKLCMGLCINTPGSYQCSCPRGYILAADMNTCRDVDECATDSINQVCTGRNDICTNIRG 766
            :  .....||||.||||.|||.|.||.||.:..|..||.||||||...    |.|.:.:|.|..|
Worm   521 IWAGSGNDLCMGGCINTKGSYLCQCPPGYKIQPDGRTCVDVDECAMGE----CAGSDKVCVNTLG 581

  Fly   767 SYKCTTVNCPLGYSIDPEQKNRCRQNLNFCE-GEECYTQPSAFTYNFITFVSKLMIPP--DGRTI 828
            |:||.:::||..|..|...||||.:..:.|. .|||...|...||.||:....:.|..  ...|:
Worm   582 SFKCHSIDCPTNYIHDSLNKNRCNRQPSACGLPEECSKVPLFLTYQFISLARAVPISSHRPAITL 646

  Fly   829 FTLRGPLWYD---NIEFDLKIVRIQATTNIQKATDGSFDTLQNNNQVN---VILKKSLEGPQDIE 887
            |.:..|...|   |.|..|| ..|....|:..|...:| .||...:.|   |.|:.||:|||.::
Worm   647 FKVSAPNHADTEVNFELQLK-TTIVGAPNVLPAIRANF-LLQKGEKRNSAVVTLRDSLDGPQTVK 709

  Fly   888 LELSMTVYTNGMPRGKSVAKLFLFVSQH 915
            |:|.:.:...|.......|.|.:.|:.|
Worm   710 LQLLLRMSKKGKNFNTYAANLIVDVAAH 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31999	NP_001284712.1	vWFA	<189..227	CDD:294047	9/38 (24%)
		EGF_CA	251..293	CDD:238011	13/41 (32%)
		EGF_CA	328..>363	CDD:214542	2/34 (6%)
		EGF_CA	519..564	CDD:214542	18/44 (41%)
		EGF_CA	565..601	CDD:238011	7/35 (20%)
		EGF_CA	611..651	CDD:284955	18/39 (46%)
		vWFA	<655..695	CDD:294047	18/39 (46%)
		cEGF	678..701	CDD:289433	11/22 (50%)
		EGF_CA	698..>730	CDD:214542	18/33 (55%)
		cEGF	721..744	CDD:289433	12/22 (55%)
fbl-1	NP_001293878.1	EGF_CA	343..380	CDD:214542	18/88 (20%)
		vWFA	<386..426	CDD:294047	19/45 (42%)
		EGF_CA	430..472	CDD:284955	25/89 (28%)
		vWFA	<469..510	CDD:294047	18/43 (42%)
		vWFA	<513..557	CDD:294047	22/43 (51%)
		cEGF	540..563	CDD:289433	12/22 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I7085
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	283	1.000	Inparanoid score	I1737
Isobase	1	0.950	-	0	Normalized mean entropy	S5629
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D106706at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto19458
orthoMCL	1	0.900	-	-		OOG6_106295
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2524
SonicParanoid	1	1.000	-	-		X2629
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.850