DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31999 and Creld1

DIOPT Version :9

Sequence 1:	NP_001284712.1	Gene:	CG31999 / 43777	FlyBaseID:	FBgn0051999	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_598691.1	Gene:	Creld1 / 171508	MGIID:	2152539	Length:	420	Species:	Mus musculus

Alignment Length:	277	Identity:	79/277 - (28%)
Similarity:	97/277 - (35%)	Gaps:	87/277 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   545 ESLLQCSPGYKSTVDGKSCIDIDECDTG-EHNCGERQICR---NRNGGFVCSCPIGHELKRSIGG 605
            :||..|.|   |...|.||:   .|..| |..||....|.   .|.|...|.|..|:       |
Mouse   137 DSLKLCCP---SGTFGPSCL---PCPGGTERPCGGYGQCEGEGTRGGSGHCDCQAGY-------G 188

  Fly   606 ASTCVDTNECAL---------EQRVC-----PLNAQCFNTIGAYYCECKAGFQKKSDGNNSTQCF 656
            ...|   .:|.|         ...||     |. |:|.....::..:||.|:     ..:..:|.
Mouse   189 GEAC---GQCGLGYFEAERNSSHLVCSACFGPC-ARCTGPEESHCLQCKKGW-----ALHHLKCV 244

  Fly   657 DIDECQVIPGLC--QQKCLNFWGGYRCTCNSGYQLGPDNRTCNDINECEVHKDYKLCMGLCINTP 719
            |||||......|  .|.|:|..|.|.|            |.|           .|.|:|.....|
Mouse   245 DIDECGTEQATCGADQFCVNTEGSYEC------------RDC-----------AKACLGCMGAGP 286

  Fly   720 GSYQC-SCPRGYILAADMNTCRDVDECATDSINQVCTGRNDICTNIRGSYKCTTVNCPLGYSIDP 783
            |  :| .|.|||....  :.|.|||||.|    .||.|.|:.|.|..|.|:|.   |..||
Mouse   287 G--RCKKCSRGYQQVG--SKCLDVDECET----VVCPGENEKCENTEGGYRCV---CAEGY---- 336

  Fly   784 EQKNRCRQNLNFCEGEE 800
                  ||....|..|:
Mouse   337 ------RQEDGICVKEQ 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31999	NP_001284712.1	vWFA	<189..227	CDD:294047
		EGF_CA	251..293	CDD:238011
		EGF_CA	328..>363	CDD:214542
		EGF_CA	519..564	CDD:214542	7/18 (39%)
		EGF_CA	565..601	CDD:238011	11/39 (28%)
		EGF_CA	611..651	CDD:284955	10/53 (19%)
		vWFA	<655..695	CDD:294047	13/41 (32%)
		cEGF	678..701	CDD:289433	4/22 (18%)
		EGF_CA	698..>730	CDD:214542	8/32 (25%)
		cEGF	721..744	CDD:289433	8/23 (35%)
Creld1	NP_598691.1	DUF3456	46..>100	CDD:371810
		CXXC. /evidence=ECO:0000250\|UniProtKB:Q19267	46..49
		FU 1	208..255		14/52 (27%)
		FU	210..245	CDD:214589	9/40 (23%)
		EGF_CA	245..>272	CDD:389777	12/38 (32%)
		FU 2	268..315		22/77 (29%)
		CXXC. /evidence=ECO:0000250\|UniProtKB:Q9CYA0	278..281		1/2 (50%)
		EGF_CA	305..337	CDD:214542	18/48 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910