DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31999 and Ltbp3

DIOPT Version :9

Sequence 1:	NP_001284712.1	Gene:	CG31999 / 43777	FlyBaseID:	FBgn0051999	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	XP_006531731.1	Gene:	Ltbp3 / 16998	MGIID:	1101355	Length:	1300	Species:	Mus musculus

Alignment Length:	944	Identity:	223/944 - (23%)
Similarity:	312/944 - (33%)	Gaps:	334/944 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 ISGYIRKCCINGLRHARTTASCKKIDIAPTIIPQLWLGLCHSTLEVCCSRELDHQD--------- 82
            :.|.:...|..|.:...:| .|:  ||....:|    |:|.            |.|
Mouse   330 VRGEVGADCPQGYKRLNST-HCQ--DINECAMP----GMCR------------HGDCLNNPGSYR 375

  Fly    83 --CELGRLAALDGTRCDGEGN--------------------VTSSSYATCCRSCQIGLAVKASKA 125
              |..|.......|:|..:..                    .|..:...||  |.:|   ||..|
Mouse   376 CVCPPGHSLGPSRTQCIADKPEEKSLCFRLVSTEHQCQHPLTTRLTRQLCC--CSVG---KAWGA 435

  Fly   126 NCKDPLFSFIFLIESYRACCYGSADFKD----QPGIDEIDKANSITDEGELPFV----------- 175
            .|:             |....|:|.||:    ..|...:....::|.:||..|.
Mouse   436 RCQ-------------RCPADGTAAFKEICPAGKGYHILTSHQTLTIQGESDFSLFLHPDGPPKP 487

  Fly   176 ---------------SEEDMNVTIVLTGDDDICGKIENLCAHICENTFDAYQCKCHPGFMLDNNN 225
                           :||:..||:    |..:..:.....:|....|...   :.:|..:...:.
Mouse   488 QQLPESPSRAPPLEDTEEERGVTM----DPPVSEERSVQQSHPTTTTSPP---RPYPELISRPSP 545

  Fly   226 VTCSPMKTQICPSGYNLDKLDNKCIDIDECREDLHDCKSSQYCHNTNGGYHCLNVKEKECPPGFH 290
            .|.......:.||...::....:..:.||||.:.:.|...|                  |.||
Mouse   546 PTFHRFLPDLPPSRSAVEIAPTQVTETDECRLNQNICGHGQ------------------CVPG-- 590

  Fly   291 YDHDYDACKDDYKCKDRKCVKIQSCDKGFSLH--NGTCSDIDECSHKSLNNCHVNSNQECVNTVG 353
                    ..||.|         .|:.|:..|  :..|.|::||..:.   |..... .|:||.|
Mouse   591 --------PSDYSC---------HCNAGYRSHPQHRYCVDVNECEAEP---CGPGKG-ICMNTGG 634

  Fly   354 SYSCNCLPGFNL--DATLNKCVDINECSINNHNCLPTQRCDNTIGSYICTRLQSCGTGYTLNAET 416
            ||:|:|..|:.|  .|....|||:|||: ..|.|.....|.|..|.|.|    :|..||.|.|..
Mouse   635 SYNCHCNRGYRLHVGAGGRSCVDLNECT-KPHLCGDGGFCINFPGHYKC----NCYPGYRLKASR 694

  Fly   417 GN-CDDDDECTLSTHNCPSNYDCHNTRGSFRCYRKISTMLTTRTTSTTVPPLSLENARRSFTSRY 480
            .. |:|.|||. ....||.. .|.|..|||:|
Mouse   695 PPICEDIDECR-DPSTCPDG-KCENKPGSFKC--------------------------------- 724

  Fly   481 PYPLAVHPEYSQNNDSISTNRRVDCSPGFYRNTLGACIDTNECMEQNPCGNHERCINTNGHFRCE 545
                                  :.|.||:.....|||.|.|||.|..|| :...|.|..|.:||
Mouse   725 ----------------------IACQPGYRSQGGGACRDVNECSEGTPC-SPGWCENLPGSYRC- 765

  Fly   546 SLLQCSPGYKSTVDGKSCIDIDECDTGEHNCGERQICRNRNGGFVCSCPIGHELKRSIGGASTCV 610
               .|:.||:...||.||||:|||:.|: .| :..||.|..|.|.|.|..|:.|.|.   .|.|.
Mouse   766 ---TCAQGYEPAQDGLSCIDVDECEAGK-VC-QDGICTNTPGSFQCQCLSGYHLSRD---RSRCE 822

  Fly   611 DTNECALEQRVCPLNAQCFNTIGAYYCECKAGFQKKSDGNNSTQCFDIDECQVIPGLC--QQKCL 673
            |.:||.. ...| :...|.||.|:|.|.|..|.:..    ...:|.|||||...||||  ...|.
Mouse   823 DIDECDF-PAAC-IGGDCINTNGSYRCLCPQGHRLV----GGRKCQDIDECSQDPGLCLPHGACE 881

  Fly   674 NFWGGYRCTCNSGYQLGPDNRTCNDINE------------------------------------- 701
            |..|.|.|.|:.|:.|..|...|.::.:
Mouse   882 NLQGSYVCVCDEGFTLTQDQHGCEEVEQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAG 946

  Fly   702 ----CEV----------------------------------HKDYKLCM---------GLCINTP 719
                ||:                                  |:|...|:         |.|:||.
Mouse   947 WGDHCEIYPCPVYSSAEFHSLCPDGKGYTQDNNIVNYGIPAHRDIDECILFGAEICKEGKCVNTQ 1011

  Fly   720 GSYQCSCPRGYILAADMNTCRDVDECATDSINQVCTGRNDICTNIRGSYKCTTVNC--PLGYS-- 780
            ..|:|.|.:|:....::..|.|||||..:|     ..||.:|.|.||.|:|.   |  |..||
Mouse  1012 PGYECYCKQGFYYDGNLLECVDVDECLDES-----NCRNGVCENTRGGYRCA---CTPPAEYSPA 1068

  Fly   781 ----IDPEQK--NRCRQNLNFCEGEECYTQPSAF 808
                :.||:.  :.| |:...|....|...|.::
Mouse  1069 QRQCLSPEEMDVDEC-QDPAACRPGRCVNLPGSY 1101

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31999	NP_001284712.1	vWFA	<189..227	CDD:294047	4/37 (11%)
		EGF_CA	251..293	CDD:238011	9/41 (22%)
		EGF_CA	328..>363	CDD:214542	12/34 (35%)
		EGF_CA	519..564	CDD:214542	18/44 (41%)
		EGF_CA	565..601	CDD:238011	15/35 (43%)
		EGF_CA	611..651	CDD:284955	12/39 (31%)
		vWFA	<655..695	CDD:294047	19/41 (46%)
		cEGF	678..701	CDD:289433	7/22 (32%)
		EGF_CA	698..>730	CDD:214542	12/115 (10%)
		cEGF	721..744	CDD:289433	7/22 (32%)
Ltbp3	XP_006531731.1	EGF_CA	352..387	CDD:214542	9/50 (18%)
		TB	411..453	CDD:366245	14/59 (24%)
		EGF_CA	613..656	CDD:214542	15/46 (33%)
		EGF_CA	657..691	CDD:238011	14/38 (37%)
		EGF_CA	700..733	CDD:214542	15/89 (17%)
		EGF_CA	741..781	CDD:214542	18/44 (41%)
		EGF_CA	782..822	CDD:214542	17/44 (39%)
		EGF_CA	823..862	CDD:214542	12/44 (27%)
		EGF_CA	863..896	CDD:214542	16/32 (50%)
		TB	926..969	CDD:366245	2/42 (5%)
		EGF_CA	1033..>1061	CDD:214542	15/35 (43%)
		EGF_CA	1079..1114	CDD:214542	5/24 (21%)
		TB	1144..>1179	CDD:366245
		EGF_CA	1251..1289	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	1	0.960