DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31999 and Fbln2

DIOPT Version :9

Sequence 1:	NP_001284712.1	Gene:	CG31999 / 43777	FlyBaseID:	FBgn0051999	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_032018.2	Gene:	Fbln2 / 14115	MGIID:	95488	Length:	1221	Species:	Mus musculus

Alignment Length:	945	Identity:	294/945 - (31%)
Similarity:	421/945 - (44%)	Gaps:	205/945 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SISGYIRKCCINGLRHARTTASCKKIDIAPTIIPQ--LWLGLCHSTLEVCCSRELDHQDCELGRL 88
            |....|..||..|.:.|.....|::       ||:  ....:|......||...|..:.|..|.:
Mouse   427 STKDLIETCCAAGQQWAIDNDECQE-------IPENGAQSDICRIAQRQCCISYLKEKSCVAGVM 484

  Fly    89 AALDGTRCDGEGNVTS--SSYATCCRSCQIGLAVKASKANCK-DPLFSF----IFLIESYRACCY 146
            .|.:|..|..|.|.|.  |.|..||..|.:||.|:|...:|: :|...:    :.|     :||.
Mouse   485 GAKEGETCGAEDNDTCGVSLYKQCCDCCGLGLRVRAEGQSCESNPNLGYPCNHVML-----SCCE 544

  Fly   147 GS-----ADFKDQP-------GIDEIDKAN----SITDEGELP-FVSEEDMNVTIVLTGDDDICG 194
            |.     .:.:..|       .:.|::.|:    |:..|.||| .:..:|.:..::|.|:
Mouse   545 GEEPLIVPEVRRPPEPEAAPRRVSEMEMASREALSLGTEAELPNSLPGDDQDECLMLPGE----- 604

  Fly   195 KIENLCAHICENTFDAYQCKCHPGFMLDNNNVTCSPMKTQICPSGYNLDKLDNKCIDIDECREDL 259
                ||.|:|.||..:|:|.|.|||.|..:..||.|               |.....:|..||..
Mouse   605 ----LCQHLCINTVGSYRCACFPGFELQGDGRTCRP---------------DRGAPQLDTARESA 650

  Fly   260 HDCKSSQYCHNTNGGYHCLNVKEKECPPGFHYDHDYDACKDDYKCKDRKC-----VKIQSCDKGF 319
            ...:|:|...||..    |.|.:.            :.|||:..|: :.|     ..:.||..|:
Mouse   651 PRSESAQVSPNTIP----LPVPQP------------NTCKDNGPCR-QVCRVVGDTAMCSCFPGY 698

  Fly   320 SL--HNGTCSDIDECSHKSLNNCHVNS-NQECVNTVGSYSC-----NCLPGFNLDATLNKCVDIN 376
            ::  ...:|.|.|||    |...|..| .|.||||:||:.|     .|..|:.|:|. .||||||
Mouse   699 AIMADGVSCEDQDEC----LMGTHDCSWKQFCVNTLGSFYCVNHTVLCAEGYILNAH-RKCVDIN 758

  Fly   377 ECSINNHNCLPTQRCDNTIGSYICTRLQSCGTGYTLNAETGNCDDDDECTLSTHNCPSNYDCHNT 441
            ||..:.|.|...:.|.||.||:.|.:..:|..||.|.  .|.|.|.|||...||||.:.:.|.||
Mouse   759 ECVTDLHTCTRAEHCVNTPGSFQCYKALTCEPGYVLT--DGECTDVDECVTGTHNCQAGFSCQNT 821

  Fly   442 RGSFRCYRKISTMLTTRTTSTTVPPLSLENARRSFTSRYPYPLAVHPEYSQNNDSISTNRRVDCS 506
            :|||.|                                                    ..|..|.
Mouse   822 KGSFYC----------------------------------------------------QARQRCM 834

  Fly   507 PGFYRNTLGACIDTNECME-QNPCGNHERCINTNGHFRCE-SLLQCSPGYKSTVDGKSCIDIDEC 569
            .||.::..|.|:|.|||.. ..||.:...||||.|.:.|: :.|.|..||.:..:|..|:|::||
Mouse   835 DGFLQDPEGNCVDINECTSLLEPCRSGFSCINTVGSYTCQRNPLVCGRGYHANEEGSECVDVNEC 899

  Fly   570 DTGEHNCGERQICRNRNGGFVCSCPIGHELKRSIGGASTCVDTNECALEQ-RVCPLNAQCFNTIG 633
            :||.|.|||.|:|.|..|.:.|.|..|  .:|...| .||:|.|||.:.. |:|  ...|.||.|
Mouse   900 ETGVHRCGEGQLCYNLPGSYRCDCKPG--FQRDAFG-RTCIDVNECWVSPGRLC--QHTCENTPG 959

  Fly   634 AYYCECKAGFQKKSDGNNSTQCFDIDECQVIPGLCQQKCLNFWGGYRCTCNSGYQLGPDNRTCND 698
            :|.|.|.|||...:||.:   |.|::||:.  ..|.|:|.|.:|.|:|.|..||||..|..||.|
Mouse   960 SYRCSCAAGFLLAADGKH---CEDVNECET--RRCSQECANIYGSYQCYCRQGYQLAEDGHTCTD 1019

  Fly   699 INECEVHKDYKLCMGLCINTPGSYQCSCP-RGYILAADMNTCRDVDECATDSINQVCTGRNDICT 762
            |:||...... ||...|:|.||||||:|| :||.:.|:..:|:|:||||..:.|  |: ..:.|.
Mouse  1020 IDECAQGAGI-LCTFRCVNVPGSYQCACPEQGYTMMANGRSCKDLDECALGTHN--CS-EAETCH 1080

  Fly   763 NIRGSYKCTTVNCPLGYSIDPEQKNRCRQNLNFCEG-EECYTQPSAFTYNFITFVSKLMIPPDGR 826
            ||:||::|...:||..|....|.|  |.:..  |:. .||.|.|:..|:..:.|.:.|::|..
Mouse  1081 NIQGSFRCLRFDCPPNYVRVSETK--CERTT--CQDITECQTSPARITHYQLNFQTGLLVPAH-- 1139

  Fly   827 TIFTLRGP---LWYDNIEFDLKIVRIQATTNIQKAT-DGSFDTLQNNNQVNVI-LKKSLEGPQDI 886
             ||.: ||   ...|.|           :..|.|.. :|.|.|.:.|....|: |::|:..|:|.
Mouse  1140 -IFRI-GPAPAFAGDTI-----------SLTITKGNEEGYFVTRRLNAYTGVVSLQRSVLEPRDF 1191

  Fly   887 ELELSMTVYTNGMPRGKSV----AKLFLFVSQHTF 917
            .|::.|.::..|     ||    ||:::|.:  ||
Mouse  1192 ALDVEMKLWRQG-----SVTTFLAKMYIFFT--TF 1219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31999	NP_001284712.1	vWFA	<189..227	CDD:294047	13/37 (35%)
		EGF_CA	251..293	CDD:238011	9/41 (22%)
		EGF_CA	328..>363	CDD:214542	16/40 (40%)
		EGF_CA	519..564	CDD:214542	17/46 (37%)
		EGF_CA	565..601	CDD:238011	16/35 (46%)
		EGF_CA	611..651	CDD:284955	18/40 (45%)
		vWFA	<655..695	CDD:294047	17/39 (44%)
		cEGF	678..701	CDD:289433	12/22 (55%)
		EGF_CA	698..>730	CDD:214542	16/32 (50%)
		cEGF	721..744	CDD:289433	11/23 (48%)
Fbln2	NP_032018.2	N	27..434		2/6 (33%)
		Subdomain NA (Cys-rich)	27..176
		Subdomain NB (Cys-free)	177..434		2/6 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	248..329
		PHA03247	<287..422	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..399
		ANATO	420..479	CDD:237984	13/58 (22%)
		Cell attachment site. /evidence=ECO:0000255	421..423
		ANATO	505..553	CDD:237984	14/52 (27%)
		FXa_inhibition	606..634	CDD:373209	12/27 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	633..661		9/42 (21%)
		vWFA	<707..749	CDD:381780	18/45 (40%)
		EGF_CA	756..>792	CDD:389777	14/35 (40%)
		EGF_CA	801..845	CDD:311536	20/95 (21%)
		EGF_CA	847..893	CDD:311536	17/45 (38%)
		EGF_CA	895..937	CDD:214542	19/44 (43%)
		FXa_inhibition	942..978	CDD:373209	15/40 (38%)
		cEGF	999..1022	CDD:372248	12/22 (55%)
		EGF_CA	1019..1061	CDD:214542	19/42 (45%)
		EGF_CA	1062..1110	CDD:311536	19/54 (35%)
		Domain III	1111..1221		35/131 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC1W
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H1514
Inparanoid	1	1.050	384	1.000	Inparanoid score	I2023
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42943
orthoMCL	1	0.900	-	-		OOG6_106295
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2524
SonicParanoid	1	1.000	-	-		X2629
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.790