DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31999 and jag1b

DIOPT Version :9

Sequence 1:	NP_001284712.1	Gene:	CG31999 / 43777	FlyBaseID:	FBgn0051999	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_571938.2	Gene:	jag1b / 140423	ZFINID:	ZDB-GENE-011128-4	Length:	1213	Species:	Danio rerio

Alignment Length:	888	Identity:	193/888 - (21%)
Similarity:	289/888 - (32%)	Gaps:	346/888 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 CDGEGNVT--------SSSYATCCRSCQIGLAVKASKANCKDPLFSFIFLIESYRACCYG-SADF 151
            ||..||.|        ..:.|.|.:.|      .....:||.|         ....|.|| ...:
Zfish   209 CDQNGNKTCLEGWTGPDCNTAICRQGC------STEHGSCKQP---------GGCKCLYGWQGPY 258

  Fly   152 KDQ----PGIDE---IDKANSITDE---GELPFVSEEDMNVTIVLTGDDDICGKIEN-LCAHICE 205
            .|:    ||...   ::....:.|.   |:|   .::|:|          .||..:. |....|.
Zfish   259 CDKCIPHPGCVHGTCVEPWQCLCDTNWGGQL---CDKDLN----------YCGTHQPCLNGGTCS 310

  Fly   206 NTF-DAYQCKCHPGFMLDNNNVTCSPMKTQICPSGYNLDKLDNKCIDIDECREDLHDCKSSQYCH 269
            ||. |.|||.|..|:                  ||.|.::.::.|:.        :.|.:...|.
Zfish   311 NTGPDKYQCSCEDGY------------------SGVNCERAEHACLS--------NPCANGGTCK 349

  Fly   270 NTNGGYHCLNVKEKECPPGFHYDHDYDACKDDYKCKDRKCVKIQSCDKGFSLHNGTCSDI---DE 331
            .|:.||.|      .|..|:          ....|:    :.:..|......|.|||.|:   .:
Zfish   350 ETSQGYEC------HCAIGW----------SGTSCE----INVDDCTPNQCKHGGTCQDLVNGFK 394

  Fly   332 CS---HKSLNNCHVNSNQ----------ECVNTVGSYSCNCLPGF---NLDATLNKCVDINECSI 380
            |:   |.:...|.:::|:          .|.|.:|:|.|.||||:   |.|      ::||:|
Zfish   395 CACPPHWTGKTCQIDANECEDKPCVNAKSCHNLIGAYFCECLPGWSGQNCD------ININDC-- 451

  Fly   381 NNHNCLPTQRCDNTIGSYICTRLQSCGTGYTLNAETGNCDDD-DECTLSTHNCPSNYDCHNTRGS 444
             ...||....|.:.:..|.|.    |..|||    ...|:.| |||..|.  |.:...|.:....
Zfish   452 -KGQCLNGGTCKDLVNGYRCL----CPPGYT----GEQCEKDVDECASSP--CLNGGRCQDEVNG 505

  Fly   445 FRCYRKISTMLTTRTTSTTVPPLSLENARRSFTSRYPYPLAVHPEYSQNNDSISTNRRVDCSPGF 509
            |:|.                                                        |..||
Zfish   506 FQCL--------------------------------------------------------CPAGF 514

  Fly   510 YRNTLGAC-IDTNECMEQNPCGNHERCINTNGHFRCESLLQCSPGYKSTVDGKSCIDI-DECDT- 571
            ...   .| :|.:.| :.|||.|..:|.|....:.|    :|...|    :||:|..: |.|.|
Zfish   515 SGQ---LCQLDIDYC-KPNPCQNGAQCFNLASDYFC----KCPDDY----EGKNCSHLKDHCRTT 567

  Fly   572 ------------------------GEHNCGERQICRNRNGG-FVCSCPIG------HELKRSIGG 605
                                    ..:.||....||::.|| |.|.|..|      ||
Zfish   568 SCQVIDSCTVAVASNSTPEGVRYISSNVCGPHGRCRSQAGGQFTCECQEGFRGTYCHE------- 625

  Fly   606 ASTCVDTNECALEQRVCPLNAQCFNTIGAYYCECKAGFQKKSDGNNSTQC-FDIDECQVIP---- 665
                 :.|:|  |...|.....|.:.:..|.|.|       :||.....| .:||:|.:.|
Zfish   626 -----NINDC--ESNPCRNGGTCIDKVNVYQCIC-------ADGWEGVHCEINIDDCSLNPCLNK 676

  Fly   666 GLCQQ-------KCLNFWGGYRC----------TCNSGYQLGPDNRTCNDINE------------ 701
            |.||.       :|.|.|.|..|          |||:|       .||:|..:
Zfish   677 GACQDLVNDFYCECRNGWKGKTCHSRDSQCDEATCNNG-------GTCHDEGDTFKCRCSPGWEG 734

  Fly   702 --CEVHKDYKLCM-------GLCINTPGSYQCSCPRGYILAADMNTCRDVDECATDSINQVCTGR 757
              |.:.|: ..|:       |.|:....|:.|.|..|:    :.:||.:    .|:..|......
Zfish   735 ATCNIAKN-SSCLPNPCENGGTCVVNGDSFNCVCKEGW----EGSTCTE----NTNDCNPHPCYN 790

  Fly   758 NDICTNIRGSYKCTTVNCPLGYSIDPEQKNRCRQNLNFCEGEECYTQPSAFTYNFITFVS--KLM 820
            :..|.:....|:|   .|..|:: .|:    ||.|:|     ||.:.|.||....:..::  :.:
Zfish   791 SGTCVDGENWYRC---ECAPGFA-GPD----CRININ-----ECQSSPCAFGSTCVDEINGYRCL 842

  Fly   821 IPPDGRTIFTLRGPLWYDNIEFDL-KIVRIQATTNIQKATDGS 862
            .|| ||.     ||        |. ::|......|.|...||:
Zfish   843 CPP-GRI-----GP--------DCQEVVGRPCIANGQVTADGA 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31999	NP_001284712.1	vWFA	<189..227	CDD:294047	12/39 (31%)
		EGF_CA	251..293	CDD:238011	8/41 (20%)
		EGF_CA	328..>363	CDD:214542	13/50 (26%)
		EGF_CA	519..564	CDD:214542	13/44 (30%)
		EGF_CA	565..601	CDD:238011	15/68 (22%)
		EGF_CA	611..651	CDD:284955	10/39 (26%)
		vWFA	<655..695	CDD:294047	17/61 (28%)
		cEGF	678..701	CDD:289433	9/32 (28%)
		EGF_CA	698..>730	CDD:214542	9/52 (17%)
		cEGF	721..744	CDD:289433	6/22 (27%)
jag1b	NP_571938.2	MNNL	29..102	CDD:284966
		DSL	164..226	CDD:279722	5/16 (31%)
		EGF_CA	293..331	CDD:238011	17/65 (26%)
		EGF	337..365	CDD:278437	9/51 (18%)
		EGF_CA	371..407	CDD:238011	8/35 (23%)
		EGF_CA	409..444	CDD:238011	10/34 (29%)
		EGF_CA	447..482	CDD:238011	12/45 (27%)
		EGF_CA	484..520	CDD:238011	12/96 (13%)
		EGF_CA	522..557	CDD:238011	13/43 (30%)
		EGF_CA	626..662	CDD:238011	10/44 (23%)
		EGF_CA	664..699	CDD:238011	11/34 (32%)
		EGF_CA	<711..737	CDD:238011	6/32 (19%)
		EGF	745..775	CDD:278437	7/33 (21%)
		EGF_CA	779..814	CDD:238011	8/42 (19%)
		EGF_CA	817..853	CDD:238011	14/54 (26%)
		VWC_out	860..927	CDD:214565	4/12 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1181..1202
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000