DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31999 and FBLN7

DIOPT Version :9

Sequence 1:	NP_001284712.1	Gene:	CG31999 / 43777	FlyBaseID:	FBgn0051999	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	XP_011508887.1	Gene:	FBLN7 / 129804	HGNCID:	26740	Length:	453	Species:	Homo sapiens

Alignment Length:	476	Identity:	111/476 - (23%)
Similarity:	169/476 - (35%)	Gaps:	161/476 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   465 PPLSLENARRSFTSRYPYPLAVHPEYSQNNDSISTNRRVDCSPGF---------------YRNTL 514
            |.|:.....|.|.|:|.....||               ..|:|||               :....
Human    82 PALNTPADGRKFGSKYLVDHEVH---------------FTCNPGFRLVGPSSVVCLPNGTWTGEQ 131

  Fly   515 GACIDTNECMEQNPCGNHERCINTNGHFRCESLLQCSPGYKSTVDGKSCIDIDECDTGEHNCGER 579
            ..|...:||..| ||.|...|:.....:||    .|.||.    .|..|         :|..
Human   132 PHCRGISECSSQ-PCQNGGTCVEGVNQYRC----ICPPGR----TGNRC---------QHQA--- 175

  Fly   580 QICRNRNGGFVCSCPIGHELKRSIGGASTCVDTNECALEQRVCPLNAQCFNTIGAYYCECKAGFQ 644
                      ..:.|.|     |:.|.|.......||..:|             |.:|.|:|||.
Human   176 ----------QTAAPEG-----SVAGDSAFSRAPRCAQVER-------------AQHCSCEAGFH 212

  Fly   645 KKSDGNNSTQCFDIDECQVIPGLCQQKCLNFWGGYRCTCNSGYQLGPDNRTCNDINECEVHKDY- 708
            ......:|                                          .|.|:||||::...
Human   213 LSGAAGDS------------------------------------------VCQDVNECELYGQEG 235

  Fly   709 --KLCMGLCINTPGSYQCSCPRGYILAADMNTCRDVDECATDSINQVCTGRNDICTNIRGSYKCT 771
              :|||..|:||||||:|:||.||...||..:|.|||||.  .:..||. :...|.|..||::|.
Human   236 RPRLCMHACVNTPGSYRCTCPGGYRTLADGKSCEDVDECV--GLQPVCP-QGTTCINTGGSFQCV 297

  Fly   772 TVNCPLG------YSIDPEQKNRCRQNLNFCEGEECYTQPSAFTYNFITFVSKLMIPPDGRTIFT 830
            :..||.|      ....|.|   |.:|....:...|...|...::::::..|.|..|   .|:|.
Human   298 SPECPEGSGNVSYVKTSPFQ---CERNPCPMDSRPCRHLPKTISFHYLSLPSNLKTP---ITLFR 356

  Fly   831 L--------RGPLWYDNIEFDLKIVRIQATTNIQKATDGSFDTLQNNNQV-NVILKKSLEGPQDI 886
            :        .||   :::.|.:          :...:.|.|...:::.|. ::||.::|||||.:
Human   357 MATASAPGRAGP---NSLRFGI----------VGGNSRGHFVMQRSDRQTGDLILVQNLEGPQTL 408

  Fly   887 ELELSMTVYTNGMPRGKSVAK 907
            |:::.|:.|.:...:...|:|
Human   409 EVDVDMSEYLDRSFQANHVSK 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31999	NP_001284712.1	vWFA	<189..227	CDD:294047
		EGF_CA	251..293	CDD:238011
		EGF_CA	328..>363	CDD:214542
		EGF_CA	519..564	CDD:214542	13/44 (30%)
		EGF_CA	565..601	CDD:238011	3/35 (9%)
		EGF_CA	611..651	CDD:284955	9/39 (23%)
		vWFA	<655..695	CDD:294047	0/39 (0%)
		cEGF	678..701	CDD:289433	2/22 (9%)
		EGF_CA	698..>730	CDD:214542	18/34 (53%)
		cEGF	721..744	CDD:289433	12/22 (55%)
FBLN7	XP_011508887.1	CCP	81..135	CDD:153056	12/67 (18%)
		EGF_CA	137..172	CDD:238011	14/52 (27%)
		EGF_CA	224..269	CDD:214542	22/44 (50%)
		EGF_CA	270..307	CDD:284955	15/39 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002570
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910