Protein Alignment CG31999 and thbs2a

DIOPT Version :10

• Sequence 1: NP_726551.2
• Gene: CG31999 / 43777
• FlyBaseID: FBgn0051999
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: XP_009305765.2
• Gene: thbs2a / 100535241
• ZFINID: ZDB-GENE-020708-2
• Length: 1175
• Species: Danio rerio
• Alignment Length: 766
• Identity: 163/766 - (21%)
• Similarity: 264/766 - (34%)
• Gaps: 239/766 - (31%)

  Fly   153 DQPGIDEI--DKANSITDEGELPFVSEEDMNVTIVLTGDDDICGKIENLCAHICENTFDAYQ--- 212
            |.| |:.|  :|...|....|:..|:|...:|::..:...:..|:.|.:.:.:||.:.:...
Zfish   218 DTP-IENILRNKGCEIAKPEEVNVVNESTESVSVGTSISTNFIGEKEKIASDVCERSCEELSNMV 281

  Fly   213 -----CKCHPGFMLDNNNVTCSPMKTQICPSGYNLDKLDNKCIDIDECREDLHDCKSSQYCHNTN 272
                 .:...|.::|                  .|.|:..:...:.|...::.:.|..:.|....
Zfish   282 QELKGLRIIVGNLID------------------GLQKVTEENTVMKEVLGNMKNIKDKRMCWQDG 328

  Fly   273 GGYHCLNVKEKECPPGFHYDHDYDACKDDYKCKDRKCVKIQSCDKGFSLHNGTCSDIDECSHKSL 337
            ..:     ::||       |...|:| ....|::.|.|    |      |..||..:...|...|
Zfish   329 RLF-----EDKE-------DWVVDSC-TKCTCQESKIV----C------HQITCPPVACASPTFL 370

  Fly   338 NN-----CHVNSNQ----------ECVNTVGSYSCNCLPGFNLDATLNKC----VDINECSINNH 383
            :.     |....::          ||..|.|:.:..  .|.:.|||.|.|    :....||:.
Zfish   371 DGECCPLCLPKDSEDGWSPWSEWTECTVTCGTGTQQ--RGRSCDATSNPCSGPSIQTRRCSLG-- 431

  Fly   384 NCLPTQRCDNTIGSYICTRLQSCGTGYTLNAETGNCD---DDDECTLSTH-NCP----SNYDCHN 440
                  :||        :|::..| |::|.:...:|.   .:.:.|...| |.|    ...||..
Zfish   432 ------KCD--------SRVRQDG-GWSLWSPWSSCSVTCGEGQITRIRHCNSPVPQLGGKDCEG 481

  Fly   441 T-RGSFRCYRKISTMLTTRTTSTTVPPLSLENARRSFTSRYPYPLAVHPEYSQNNDSIS------ 498
            : |.:.:|..|               |..::.|...::     |.||        .|::
Zfish   482 SGRETQKCEAK---------------PCPIDGAWGPWS-----PWAV--------CSVTCGGGTR 518

  Fly   499 TNRRVDCSP-----GFYRNTLGACIDTNECMEQ---------NPCGNHERCINT-NGHFRCESLL 548
            |..||..||     |  :...|..:|||.|.:|         |||.....|.:: :|.:.|.
Zfish   519 TRTRVCNSPRPQYGG--KKCPGDSVDTNACNKQDCPVDGCLSNPCFGGVECTSSPDGSWECG--- 578

  Fly   549 QCSPGYKSTVDGKSCIDIDECDTGEHNC---GERQICRNRNGGFVC-SCPIGHELKRSIG----- 604
            .|..|::.  :||.|.|::|||.....|   |:.|.|.|.:.||.| .||..::..:..|
Zfish   579 PCPLGFRG--NGKVCEDVNECDMVPDLCYKVGDSQRCVNTDPGFHCLPCPPRYKGNQPFGMGVEA 641

  Fly   605 ---GASTCVDTNECALEQRVCPLNAQCFNTIG-----AYYCECKAGFQKKSDGNNSTQCFDIDEC 661
               ....|...|.|..:...|..:|:|. .:|     .:.||||.|:  ..||....:..|:|
Zfish   642 AKLNKQVCEQENPCKEKTHNCHRSAECI-YLGHFSEPMFKCECKIGY--AGDGLICGEDSDLD-- 701

  Fly   662 QVIPGLCQQKCLNFWGGYRCTCNSGYQLGPDNRTCNDI--------------NECEVHKDYKLCM 712
                |...|..:       |..|..|....||  |..:              :.|:...|....|
Zfish   702 ----GWPNQNLV-------CGANQSYHCKKDN--CPKLPNSGQEDFDKDGQGDACDKDDDNDGIM 753

  Fly   713 GLCINTPGSY--------------QC-SCPRGYILA-ADMNTCRDVDECATDSINQVCTGRNDIC 761
            ....|.|..|              :| :||..:..| .|.:...:.|.||.|.........||.|
Zfish   754 DETDNCPLLYNPRQFDYDKDLVGDRCDNCPYEHNPAQIDTDGNGEGDACAVDIDGDEVLNENDNC 818

  Fly   762 ----------TNIRG-SYKCTTVNCPLGYSIDPEQKNRCRQNLNFCEGEEC 801
                      |::.| ..:|.  ||||.:  :|||.:.....:    |:||
Zfish   819 PYMYNTDQKDTDMDGVGDQCD--NCPLLH--NPEQTDSDNDRV----GDEC 861

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31999	NP_726551.2	vWFA	<189..227	CDD:469594	6/45 (13%)
		EGF_CA	251..293	CDD:238011	5/41 (12%)
		EGF_CA	328..>363	CDD:214542	7/49 (14%)
		EGF_CA	421..447	CDD:429571	7/31 (23%)
		EGF_CA	519..564	CDD:214542	15/54 (28%)
		EGF_CA	565..601	CDD:238011	14/39 (36%)
		EGF_CA	611..642	CDD:429571	10/35 (29%)
		FXa_inhibition	661..696	CDD:464251	7/34 (21%)
		EGF_CA	698..>730	CDD:214542	9/60 (15%)
		cEGF	723..744	CDD:463661	5/22 (23%)
thbs2a	XP_009305765.2	None