DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31999 and efemp1

DIOPT Version :9

Sequence 1:	NP_001284712.1	Gene:	CG31999 / 43777	FlyBaseID:	FBgn0051999	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	XP_002936872.1	Gene:	efemp1 / 100495975	XenbaseID:	XB-GENE-1012537	Length:	460	Species:	Xenopus tropicalis

Alignment Length:	595	Identity:	168/595 - (28%)
Similarity:	236/595 - (39%)	Gaps:	164/595 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   341 HVNSNQECVNTVGSYSCNCLPGFNLDATLNKCVDINECSINNHNCLPTQRCDNTIGSYICTRLQS 405
            |....|:...|: :|: .|..|:..|....:|.||:||.|.:..|....:|.|..|.|:|
Frog    12 HFTCAQDTEETI-TYT-QCTDGYEWDPMRQQCKDIDECEIVHDACKGGMKCVNHFGGYLC----- 69

  Fly   406 CGTGYTLNAETGNCDDDDECTLSTHNCPSNYDCHNTRGSFRCYRKISTMLTTRTTSTTV--PPLS 468
              ...|......|..||..   :|...|:.                |..:..:.|:..|  ||
Frog    70 --LPRTAQILVNNGQDDSP---NTPQEPAG----------------SQQINGQNTAVEVHNPP-- 111

  Fly   469 LENARRSFTSRYPYPLAVHPEYSQNNDSISTNRRVDCSPGFYRNTLGACIDTNECMEQNPCGNHE 533
              |.::           |.|...|.
Frog   112 --NVQQ-----------VVPNAPQR---------------------------------------- 123

  Fly   534 RCINTNGHFRCESLLQCSPGYKSTVDGKSCIDIDECDTGEHNCGERQICRNRNGGFVCSCPIGHE 598
                          :||:|||:.|.. ..|.|||||..|.|||...|:|.|..|.|.|.||.|
Frog   124 --------------IQCAPGYEPTAQ-NMCQDIDECAAGTHNCRSDQVCSNLRGSFSCQCPRG-- 171

  Fly   599 LKRSIGGASTCVDTNECALEQRVCPLNAQCFNTIGAYYCECKAGFQKKSDGNNSTQCFDIDECQV 663
            |:|.   ...|:|.:||||......|   |.||.|:|||:|..|||..:   |:..|.|||||..
Frog   172 LQRR---GDQCIDIDECALSSYCHHL---CVNTFGSYYCQCNPGFQLSA---NNYSCTDIDECAS 227

  Fly   664 IPGLCQQKCLNFWGGYRCTCNSGYQLGPDNRTCNDINECEVHKDYKLCMGLCINTPGSYQCSCPR 728
            .|  |.|:|.|..|.|.|.||:||:|..|...|.||:||.. ..| ||...|:|.||.:.|.||.
Frog   228 SP--CAQECYNMVGSYFCQCNAGYELSRDRVNCEDIDECRT-SSY-LCQYQCVNEPGRFSCICPE 288

  Fly   729 GYILAADMNTCRDVDECATDSINQVCTGRNDICTNIRGSYKCTTVNCPLGYSIDPEQKNRCRQNL 793
            ||.||. ..||:|::||.||:.:  | |.:.:|.|..|:|:|        |..:|.|:...|.:.
Frog   289 GYQLAG-TRTCQDINECDTDAHD--C-GEDTMCWNYYGAYRC--------YPRNPCQEPYVRMSE 341

  Fly   794 NFC----EGEECYTQPSAFTYNFITFVSKLMIPPDGRTIFTLRGPLWYDNIEFDLKIVRIQATTN 854
            |.|    ....|..||.:..|.:::..|...:|.|   ||.::..:.|.|            |.|
Frog   342 NRCVCPVANPICRDQPYSILYKYMSIHSNRPVPAD---IFQIQATMIYSN------------TIN 391

  Fly   855 IQKATDGSFDTLQNNNQ-----------VNVILKKSLEGPQDIELELSMTVYTNGMP-RGKSVAK 907
            ..:...|      |.||           ..:::.|.|.||::..::|.|....:.|. |..|:.:
Frog   392 TFRIKSG------NENQDFYLRHTSGISAMLVMVKPLTGPREYIVDLEMVTVNSLMNYRSSSILR 450

  Fly   908 LFLFVSQHTF 917
            |.:.|..::|
Frog   451 LTIVVGPYSF 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31999	NP_001284712.1	vWFA	<189..227	CDD:294047
		EGF_CA	251..293	CDD:238011
		EGF_CA	328..>363	CDD:214542	5/21 (24%)
		EGF_CA	519..564	CDD:214542	6/44 (14%)
		EGF_CA	565..601	CDD:238011	19/35 (54%)
		EGF_CA	611..651	CDD:284955	17/39 (44%)
		vWFA	<655..695	CDD:294047	20/39 (51%)
		cEGF	678..701	CDD:289433	11/22 (50%)
		EGF_CA	698..>730	CDD:214542	14/31 (45%)
		cEGF	721..744	CDD:289433	10/22 (45%)
efemp1	XP_002936872.1	EGF_CA	140..177	CDD:311536	20/41 (49%)
		EGF_CA	181..215	CDD:214542	17/39 (44%)
		vWFA	<219..257	CDD:381780	20/39 (51%)
		cEGF	240..263	CDD:372248	11/22 (50%)
		vWFA	<258..293	CDD:381780	17/36 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11029
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910