DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31999 and crb2

DIOPT Version :9

Sequence 1:	NP_001284712.1	Gene:	CG31999 / 43777	FlyBaseID:	FBgn0051999	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	XP_002937280.2	Gene:	crb2 / 100487355	XenbaseID:	XB-GENE-989701	Length:	1456	Species:	Xenopus tropicalis

Alignment Length:	711	Identity:	173/711 - (24%)
Similarity:	244/711 - (34%)	Gaps:	257/711 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 IVLTGDDDICGKIENLCA-------HICENT--FDAYQCKCHPGFMLDN--NNVTCSPMKTQICP 237
            :..||  ..||.:.:.||       |.|::|  ...:||.|.||....|  ...:| |.:...|.
Frog    59 LAFTG--TTCGDLYDACAIDRCPSTHSCQSTPGHPHFQCVCQPGLNCTNECQRNSC-PFQNFQCT 120

  Fly   238 SGYNLDKLDNKCIDIDECREDLHDCKSSQYCHNTNGGYHCLNVKEKECPPGFHYDHDYDACKDDY 302
            .|                 ||...||    |.:..||..|    ..|..|.|.     :.|:::.
Frog   121 VG-----------------EDSFMCK----CQSGYGGVDC----NFEVSPCFQ-----NPCQNNA 155

  Fly   303 KC----KDRKCVKIQSCDKGFSLHNGTCSDIDECSHKSLNNCHVNSNQE---CVNTVGSYSCNCL 360
            .|    ...:||    |:.||:   |     .|| ..::|.|..|..|.   ||:.|..|.|.|:
Frog   156 TCLAEGDSFRCV----CEPGFT---G-----QEC-EVNVNECASNPCQNEALCVDKVDRYMCFCV 207

  Fly   361 PGFNLDATLNKC-VDINECSINNHNCLPTQRCDNTIGSYICTRLQSCGTGYTLNAETG-NCD-DD 422
            |||.    .:.| :|||||:  :..|.....|.|.:..|.|    :|..||     || ||: :.
Frog   208 PGFQ----GHHCEIDINECA--SRPCQNNGTCMNQLDQYEC----ACANGY-----TGINCEMEI 257

  Fly   423 DECTLSTHNCPSNYDCHNTRGSFRCYRKISTMLTTRTTSTTVPPLSLENARRSFTSRYPYPLAVH 487
            |||  .:..|.:...|.:..|.|.|
Frog   258 DEC--QSVPCQNGATCRDHIGYFTC---------------------------------------- 280

  Fly   488 PEYSQNNDSISTNRRVDCSPGFYRNTLGACIDTNECMEQNPCGNHERCINTNGHFRCESLLQCS- 551
                            ||..|:........||  ||..| ||.|..:|::....|||:    ||
Frog   281 ----------------DCPAGYDGEQCQHDID--ECQSQ-PCQNGGQCMDEINRFRCD----CSN 322

  Fly   552 PGYKSTVDGKSCIDIDECDTGEHNCGERQICRNRNGGFVCSCPIGHELKRSIGGASTCVDTNECA 616
            .|:   |.|:..::|.|||:  :.|.....|..|..|:.|.|..|:      .|....:|.|||.
Frog   323 TGF---VGGRCEVEILECDS--NPCQNNGTCMERVNGYECLCWKGY------SGIHCEIDDNECF 376

  Fly   617 LEQRV----C-------------PLNAQCFNTIGAYYCECKAGFQKKSDGNNSTQCFDIDECQVI 664
            .|..|    |             ..|...::....|.|.|:.||    .|.|.:  .:||||:..
Frog   377 EEPCVNGGLCLELSNQSYYGTEPEFNKFSYSQAAGYLCRCQQGF----TGPNCS--VNIDECESW 435

  Fly   665 PGLCQQKCLNFWGGYRCTCNSGYQLGPDNRTCN-DINECEVHKDYKLCMGL-CINTPGSYQCSCP 727
            |.|....|.:...|:.|.|.||| .|.|   |: :|:||   ||.....|. |.:....|.|.||
Frog   436 PCLNGGTCTDLINGFLCNCASGY-TGFD---CSINIDEC---KDSPCKNGASCEDGVADYSCICP 493

  Fly   728 RG--------------YILAADMNTCRDVDECATDSINQVCTGRNDICTNIRGSYKCTTVNCPLG 778
            ..              .::....::|::..||.     .:.||::.       ||.|   .|..|
Frog   494 PAAQDGTVWGGKNCSVMLIGCLEHSCQNAAECI-----PLYTGQSH-------SYTC---KCQPG 543

  Fly   779 YSIDPEQKNRCRQNLNFCEGEECYTQPSAFTYNFITFVSKLMIPPDGRTIFTLRGPLWYDN 839
            :                 .|..|.| |:.|:                   |..:|.|.||:
Frog   544 F-----------------VGNNCST-PTTFS-------------------FLSQGYLMYDS 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31999	NP_001284712.1	vWFA	<189..227	CDD:294047	13/48 (27%)
		EGF_CA	251..293	CDD:238011	11/41 (27%)
		EGF_CA	328..>363	CDD:214542	13/37 (35%)
		EGF_CA	519..564	CDD:214542	16/45 (36%)
		EGF_CA	565..601	CDD:238011	11/35 (31%)
		EGF_CA	611..651	CDD:284955	14/56 (25%)
		vWFA	<655..695	CDD:294047	15/39 (38%)
		cEGF	678..701	CDD:289433	10/23 (43%)
		EGF_CA	698..>730	CDD:214542	11/46 (24%)
		cEGF	721..744	CDD:289433	5/36 (14%)
crb2	XP_002937280.2	EGF_CA	<149..178	CDD:238011	10/41 (24%)
		EGF_CA	180..216	CDD:238011	13/39 (33%)
		EGF_CA	218..254	CDD:238011	16/46 (35%)
		EGF_CA	257..292	CDD:238011	11/92 (12%)
		EGF_CA	294..331	CDD:238011	17/46 (37%)
		EGF_CA	336..369	CDD:238011	11/40 (28%)
		EGF_CA	428..463	CDD:238011	15/38 (39%)
		EGF_CA	466..>494	CDD:214542	10/30 (33%)
		Laminin_G_2	582..712	CDD:366983
		EGF_CA	742..771	CDD:238011
		Laminin_G_2	807..921	CDD:366983
		EGF_CA	<961..990	CDD:238011
		Laminin_G_2	1046..1160	CDD:366983
		EGF_CA	1196..1227	CDD:238011
		EGF_CA	1229..1264	CDD:238011
		EGF_CA	1266..1302	CDD:238011
		EGF_CA	1345..1381	CDD:238011
		Insulin_TMD	<1396..1427	CDD:375394
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910