DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31999 and fbln2

DIOPT Version :9

Sequence 1:	NP_001284712.1	Gene:	CG31999 / 43777	FlyBaseID:	FBgn0051999	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	XP_017949170.2	Gene:	fbln2 / 100487324	XenbaseID:	XB-GENE-959371	Length:	1029	Species:	Xenopus tropicalis

Alignment Length:	801	Identity:	233/801 - (29%)
Similarity:	329/801 - (41%)	Gaps:	228/801 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 LIESYRACCYGSADFKDQPGIDEIDKANSITDEGE---LPFVSEEDMNVTIVLTGDDDICGKIEN 198
            |:|:   ||.....:.              .|.||   :|..:.|:             |...|.
Frog   430 LVET---CCAAGQQWS--------------IDHGECENMPLSASEE-------------CRLAEK 464

  Fly   199 LC--AHICENTFDAYQCKCHPGFMLDNNNVTCSPMKTQICPSGYNLDKLDNKCIDIDECREDLHD 261
            .|  ::|.|||       |..|.:....:..|.|.:..||...|  .||   |.|.  |...|..
Frog   465 QCCISYIKENT-------CIAGMIAAKEDGICLPAENDICERSY--FKL---CCDC--CSWGLKV 515

  Fly   262 CKSSQYCH-NTNGGY---H----CLNVKEKECPPGFHYDHDYDACKDDYKCKDRKCVKIQSCDKG 318
            .|....|. |.|.||   |    |.|.:|:..||        ||             ||.|..:.
Frog   516 RKEGSSCESNLNLGYPCNHMMILCCNGEEQLIPP--------DA-------------KIPSKPEL 559

  Fly   319 FSLHNGTCSDIDECSHKSLNNCHVNSNQECVNTVGSYSC----NCLPGFNLDATLNKCVDINECS 379
            ..|..   :|||||   .||.......:.|||||||:.|    .|..||.:  ....|.||:||.
Frog   560 LVLPE---ADIDEC---VLNTHTCIQGERCVNTVGSFICIQEERCESGFTV--VNGACTDIDECV 616

  Fly   380 INNHNCLPTQRCDNTIGSYICTRLQSCGTGYTLNAETGNCDDDDECTLSTHNCPSNYDCHNTRGS 444
            ||.|.|...:||.||:|||||.:.:.|..||||  ..|.|.|.:||......|...:.|.||.||
Frog   617 INRHTCATGERCVNTVGSYICIQERRCEIGYTL--VDGVCTDINECASLAAPCKQGFTCVNTLGS 679

  Fly   445 FRCYRKISTMLTTRTTSTTVPPLSLENARRSFTSRYPYPLAVHPEYSQNNDSISTNRRVDCSPGF 509
            |.|.||
Frog   680 FVCQRK----------------------------------------------------------- 685

  Fly   510 YRNTLGACIDTNECMEQNPCGNHERCINTNGHFRCESLLQCSPGYKSTVDGKSCIDIDECDTGEH 574
                                                 .|:|:.||:|..:|..|||||||..|.|
Frog   686 -------------------------------------QLKCNKGYESDENGTICIDIDECKLGTH 713

  Fly   575 NCGERQICRNRNGGFVCSCPIG--HELKRSIGGASTCVDTNECAL-EQRVCPLNAQCFNTIGAYY 636
            ||.:.|.|.|..|...|.|.||  ::|.|     ..|:|.|||.: ..|:|  :..|.||:|:|.
Frog   714 NCSQEQSCFNLPGSHRCDCKIGYRYDLFR-----KACLDVNECWIYPGRLC--HHTCENTVGSYK 771

  Fly   637 CECKAGFQKKSDGNNSTQCFDIDECQVIPGLCQQKCLNFWGGYRCTCNSGYQLGPDNRTCNDINE 701
            |.|.||||...||.   ||.|::||:..|  |.|:|.|.:|.|:|.|..||:|..|..:|.||:|
Frog   772 CSCFAGFQLGQDGK---QCEDVNECKSNP--CNQECTNVYGSYQCYCKEGYKLADDGISCEDIDE 831

  Fly   702 CEVHKDYKLCMGLCINTPGSYQCSCPR-GYILAADMNTCRDVDECATDSINQVCTGRNDICTNIR 765
            | |.....||:..|:||||||||:||. ||.|:.:..||:|:|||...:.|  |:...: |.||:
Frog   832 C-VQNFGSLCVFACVNTPGSYQCACPETGYTLSVNGRTCKDIDECEVGTHN--CSSSEE-CYNIQ 892

  Fly   766 GSYKCTTVNCPLGYSIDPEQKNRCRQNLNFCEGEECYTQPSAFTYNFITFVSKLMIPPDGRTIFT 830
            |||||.:..||..|.   :..|...:.::....:||...|...:|..:||.:.:::|..   ||.
Frog   893 GSYKCLSYTCPENYR---KVSNMVCERISCFNYQECQNSPVRISYLRLTFPAGVVVPAQ---IFR 951

  Fly   831 LRGPLWY--DNIEFDLKIVRIQATTNIQKATDGSFDTLQNNNQVNVI-LKKSLEGPQDIELELSM 892
            :.....|  |:|..|:|          :...:..|.:.:.|....:| |::.::..:|..|::.|
Frog   952 IGPSPTYAGDSIVLDIK----------KGNEENYFSSRKFNPYTGIIYLQRPVKKAKDFLLDVEM 1006

  Fly   893 TVYTNGMPRGKSVAKLFLFVS 913
            .::..|:.. ..::::::|::
Frog  1007 KLFRQGVVT-TFLSRIYVFIT 1026

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31999	NP_001284712.1	vWFA	<189..227	CDD:294047	9/39 (23%)
		EGF_CA	251..293	CDD:238011	15/49 (31%)
		EGF_CA	328..>363	CDD:214542	16/38 (42%)
		EGF_CA	519..564	CDD:214542	6/44 (14%)
		EGF_CA	565..601	CDD:238011	18/37 (49%)
		EGF_CA	611..651	CDD:284955	19/40 (48%)
		vWFA	<655..695	CDD:294047	17/39 (44%)
		cEGF	678..701	CDD:289433	10/22 (45%)
		EGF_CA	698..>730	CDD:214542	18/32 (56%)
		cEGF	721..744	CDD:289433	12/23 (52%)
fbln2	XP_017949170.2	ANATO	503..546	CDD:412122	16/47 (34%)
		EGF_CA	566..603	CDD:214542	17/39 (44%)
		EGF_CA	611..648	CDD:214542	19/36 (53%)
		EGF_CA	656..698	CDD:214542	18/137 (13%)
		EGF_CA	704..745	CDD:311536	19/45 (42%)
		cEGF	769..792	CDD:403760	12/25 (48%)
		cEGF	808..831	CDD:403760	10/22 (45%)
		cEGF	850..874	CDD:403760	12/23 (52%)
		EGF_CA	871..>907	CDD:311536	16/38 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11053
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	311	1.000	Inparanoid score	I2549
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D106706at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48069
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2524
SonicParanoid	1	1.000	-	-		X2629
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.000