DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31999 and LOC100333499

DIOPT Version :9

Sequence 1:	NP_001284712.1	Gene:	CG31999 / 43777	FlyBaseID:	FBgn0051999	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	XP_021323601.1	Gene:	LOC100333499 / 100333499	-ID:	-	Length:	2049	Species:	Danio rerio

Alignment Length:	1056	Identity:	278/1056 - (26%)
Similarity:	396/1056 - (37%)	Gaps:	351/1056 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 TMASDSI----SGYIRKCCINGLRHARTTASCKKIDIAPTIIPQLWLGLCHSTL------EVCC- 74
            |:..||:    ||:  |.|...:|:                      |.|.|.|      |:||
Zfish   451 TIRGDSVYTESSGF--KYCFREVRN----------------------GQCSSPLPGLRSQEMCCR 491

  Fly    75 --SRELDHQDCEL----------GRLAA------LDGTRC-------------DGEGNVTSSSYA 108
              .:.....:|.|          |:.:.      ::||:|             :|....|..||:
Zfish   492 GVGKAWGINECTLCPAISGNSVNGQASCPKGFDRVNGTQCVDINECLQPGFCENGNCVNTRGSYS 556

  Fly   109 TCCRSCQIGLAVKASKANC---------KDPLFSFIFL----------IESYRACC--------- 145
            ..|..   |..:.||...|         ||..|..:..          |.....||
Zfish   557 CVCNE---GFLLDASHGICISQKVISEEKDQCFRILNQGACSLPILRNITKQICCCSRVGKAWGK 618

  Fly   146 -------YGSADFKD----QPG--------------IDEIDK----------------------- 162
                   :|||.||:    .||              .|.:|.
Zfish   619 KCELCPFFGSAAFKEICPAGPGYHYSASAVKINQRVADIVDSSGTNVRTSTQDKQTQPESSRTNS 683

  Fly   163 --------ANSITDEGELPFVSEE------DMNVTIVLTG---DDDICGKIENLCA--------- 201
                    :|:.|...:.|.:|:.      |....|::|.   :....|:..|:.|
Zfish   684 QSTRTQQTSNTHTIRVQQPSISQSSRPQQPDTGSVIIITQPKLNQPTAGRTTNIHAGNSPSSTSQ 748

  Fly   202 ------------------------------------------HICENTFDA-------------Y 211
                                                      .:||:....             :
Zfish   749 PARVNTPVIRTQTSRPSVNRQPVSPVRPPPVTPRPPPTRQDVRVCESRPQVCGPGRCIDLPGGRH 813

  Fly   212 QCKCHPGFML--------DNNNVTCSPMKTQ-------------ICPSGYNLDKLDNKCIDIDEC 255
            .|.|:.||:|        |.|....:|....             :||:||..:.....|:|:|||
Zfish   814 TCVCNTGFILNPQQGHCQDKNECVLTPRPCSVGECVNTPGSFRCVCPAGYQTNSQQTLCVDLDEC 878

  Fly   256 REDLHDCKSSQYCHNTNGGYHCLNVKEKECPPGFHYDH----DYDACKDDYKCKDRKCVKIQ--- 313
            |:..:.|.:.: |.||.|.:.|:      |..|:....    |.|.|.|..:|..::||..|
Zfish   879 RQVPNPCINGR-CENTLGSFRCV------CRTGYKLQDNSCIDIDECVDPLRCPGKECVNSQGSY 936

  Fly   314 ---SCDKGFSLHNGTCSDIDECSHKSLNNCHVNSNQECVNTVGSYSCNCLPGFNLDATLNKCVDI 375
               ||..||.|.||.||||||| .::.:.|   .:..|.||.||:.|:|..|:.|.|  |.|||:
Zfish   937 RCVSCRPGFDLLNGQCSDIDEC-RRTPSPC---PDGRCENTAGSFRCSCRTGYRLQA--NTCVDV 995

  Fly   376 NECSINNHNCLPTQRCDNTIGSYICTRLQSCGTGYTLNAETGNCDDDDECTLSTHNCPSNYDCHN 440
            |||. :...| |.|.|.|:.|||.|.   ||..|:.|  ..|.|.|.|||..:...| .|..|.|
Zfish   996 NECE-DPSQC-PGQECLNSQGSYRCV---SCRPGFGL--RNGACSDIDECRQTPSPC-QNGLCEN 1052

  Fly   441 TRGSFRCYRKISTMLTTRTTS--------TTVPPLSLENARRSFTSRYPYPLAVHPEYSQNNDSI 497
            |.|||||..:....|...|.:        :..|.....|::.|:..     ::..|.:...|.:.
Zfish  1053 TLGSFRCVCRTGYRLQGGTCTDVNECEDPSQCPGQECLNSQGSYRC-----VSCRPGFGLRNGAC 1112

  Fly   498 S------------TNRRVD---------CSPGFYRNTLGACIDTNECMEQNPCGNHERCINTNGH 541
            |            .|.|.:         |.||| |.....|.|.|||..:..|...| |:|:.|.
Zfish  1113 SDIDECRQTPDLCVNGRCENTMGSYSCSCRPGF-RLEENICKDVNECENELQCPGME-CVNSVGS 1175

  Fly   542 FRCESLLQCSPGYKSTVDGKSCIDIDECDTGEHNCGERQICRNRNGGFVCSCPIGHELKRSIGGA 606
            |:|.|   |.||:: .:||: |.|:|||......|...| |:|..|.|.|.|.:|..|:..:
Zfish  1176 FKCVS---CKPGFQ-LLDGQ-CQDVDECSRTPRRCTNGQ-CKNTPGSFRCVCDVGFHLQDGV--- 1231

  Fly   607 STCVDTNECALEQRVCPLNAQCFNTIGAYYC-ECKAGFQKKSDGNNSTQCFDIDECQVIPGLC-- 668
              |.|.:|| ::...|| ..||.|:.|:|.| .|:.|...:|.     :|.||||| |...:|
Zfish  1232 --CTDMDEC-VDPLQCP-GQQCINSPGSYKCVPCRDGHSMQSG-----RCTDIDEC-VSDQVCGA 1286

  Fly   669 QQKCLNFWGGYRCTCNSGYQLGPDNRTCNDINECEVHKDYKLCMGLCINTPGSYQCSCPRGYILA 733
            |..|:|..|.|||.|..||:.....|.|.||||| :..|:....|.|:||.|||:|.|.:||...
Zfish  1287 QSVCVNTDGSYRCDCAPGYRAAGAGRQCRDINEC-LEGDFCFPRGECVNTDGSYKCVCSQGYKSV 1350

  Fly   734 ADMNTCRDVDECATDSINQVCTGRNDICTNIRGSYKCTTVNCPLGYSIDPEQK-----NRCRQNL 793
            |:..:|:||||||.|.:.|  .||   |:|..||:.|   :|..|::.:||:.     |.|:.:.
Zfish  1351 ANGTSCQDVDECALDGVCQ--DGR---CSNTEGSFLC---HCQTGFTTNPEKTACLDVNECQDST 1407

  Fly   794 N-FCEGEECYTQPSAF 808
            . .|..:.|.....:|
Zfish  1408 GLICGSQRCENTIGSF 1423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31999	NP_001284712.1	vWFA	<189..227	CDD:294047	12/109 (11%)
		EGF_CA	251..293	CDD:238011	13/41 (32%)
		EGF_CA	328..>363	CDD:214542	13/34 (38%)
		EGF_CA	519..564	CDD:214542	17/44 (39%)
		EGF_CA	565..601	CDD:238011	14/35 (40%)
		EGF_CA	611..651	CDD:284955	14/40 (35%)
		vWFA	<655..695	CDD:294047	18/41 (44%)
		cEGF	678..701	CDD:289433	10/22 (45%)
		EGF_CA	698..>730	CDD:214542	15/31 (48%)
		cEGF	721..744	CDD:289433	10/22 (45%)
LOC100333499	XP_021323601.1	EGF_CA	533..>563	CDD:214542	5/32 (16%)
		TB	594..634	CDD:307020	8/39 (21%)
		SSL_OB	644..>767	CDD:332684	12/122 (10%)
		EGF_CA	832..865	CDD:214542	7/32 (22%)
		EGF_CA	874..908	CDD:238011	13/40 (33%)
		EGF_CA	914..>945	CDD:214542	10/30 (33%)
		EGF_CA	954..988	CDD:238011	14/37 (38%)
		EGF_CA	994..1029	CDD:238011	17/41 (41%)
		EGF_CA	1034..1073	CDD:214542	16/39 (41%)
		EGF_CA	1074..1109	CDD:238011	4/39 (10%)
		EGF_CA	1114..1146	CDD:214542	6/32 (19%)
		EGF_CA	1194..1226	CDD:214542	13/32 (41%)
		EGF_CA	1274..1314	CDD:214542	18/40 (45%)
		EGF_CA	1316..1357	CDD:214542	18/41 (44%)
		EGF_CA	1358..1390	CDD:214542	17/39 (44%)
		EGF_CA	1443..1484	CDD:214542
		TB	1582..1619	CDD:307020
		EGF_CA	1681..>1709	CDD:214542
		TB	1745..1785	CDD:307020
		Atrophin-1	<1815..1950	CDD:331285
		cEGF	1985..2008	CDD:315355
		EGF_CA	2005..2042	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910