DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31999 and egf

DIOPT Version :9

Sequence 1:	NP_001284712.1	Gene:	CG31999 / 43777	FlyBaseID:	FBgn0051999	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_001106478.1	Gene:	egf / 100127663	XenbaseID:	XB-GENE-951823	Length:	1051	Species:	Xenopus tropicalis

Alignment Length:	857	Identity:	173/857 - (20%)
Similarity:	266/857 - (31%)	Gaps:	355/857 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 LDNNNVTCSPMKTQICPSGYNLDKLDNKCI----DIDECRED--LHDCKSSQYCHNTNGG----- 274
            ||.:||| |.::......|..||..|.|..    .||  |||  :..|       :.||.
Frog   189 LDGSNVT-SIIELSGALKGLTLDTDDKKIFWILSKID--REDSVIGSC-------SYNGDSVMIV 243

  Fly   275 --------YHCLNVKEKECPPGFHYDHDYDACKDDYKCK--------------------DRKCVK 311
                    ||.|.|       ...|:|.|.:.:.....|                    :.:.:|
Frog   244 KNLRLSTKYHVLGV-------SLLYNHIYYSERKSGSIKVINKFTGKDIVSVNLKPSIMEIRNIK 301

  Fly   312 IQSCDKGFSLHNGTCSDIDECSHKSLNNCHVNSNQECVNT----VGSYSCNCLPGFNLDATLNKC 372
            :....:.:|:.|.:       |::...:|.: ||:.|..|    ..:..|:|:.||.|.:....|
Frog   302 VVYPVRSYSIPNSS-------SNQGAKSCSI-SNKHCTKTCEIDAENQKCHCMNGFVLSSNGRYC 358

  Fly   373 VDINECSINNHNCLPTQRCDNTIGSYICTRLQSCGTGYTLNAETGNCDDDDECTLS----THNC- 432
            .|||||::.||.|  |..|:|..|||.||    |..||.|..:...|.|...|...    :|.|
Frog   359 EDINECALWNHGC--TLGCENIPGSYFCT----CPEGYVLLPDNKTCHDKTPCLTEHIECSHGCV 417

  Fly   433 ----------------------------PSNYDCHNT-----RGSFRCYRKISTMLTTRTTSTTV 464
                                        |.|..|.:.     .|::.|              ...
Frog   418 QTTKGPLCTCPEGSVLSEDGKSCTGCTSPDNGGCSHICIMSGPGTWEC--------------DCF 468

  Fly   465 PPLSLENARRSFTSRYPYPLAVHPEYSQNNDSISTNRRVDCSPGFYRNTLGACIDTNECMEQNPC 529
            |..:|:..|:...:..|.|..:..       ::...||::.....|.:.|.:.|.....::.:|.
Frog   469 PGYNLQLDRKQCLASGPRPYLMFA-------NVHDIRRINFDGTNYESVLDSQIGRVFALDYDPV 526

  Fly   530 GNHE-------RCI---NTNGHFRCESL---LQCSPGYKSTVD-----------GKSCIDIDECD 570
            .:..       :||   |.:|..|.:.:   |....|.  |||           |||||:..:.:
Frog   527 EDRMYFAHTALKCIESANMDGSDRKKMISGDLSTLEGL--TVDAINRKLYWTDRGKSCIERSDLN 589

  Fly   571 -------TGEHNCGERQICRNRNGGFVCSCPIGHELKRSIGGASTCVDTNECALEQRVCPLNAQC 628
                   ..|:|...|.||.:         |:..:|..:..||:..:::::....:|...::...
Frog   590 GKYRKILIQENNIQPRGICVH---------PLAKKLFWTHVGANPRIESSDLEGSEREVIISKDL 645

  Fly   629 FNTIG---------AYYCECKAGF----------------------------------------- 643
            ....|         .|:|:.|...
Frog   646 IWPSGITVDHLTDVIYWCDAKKSVIESANLDGSNRQSFSQNDVGHPFAISVFEDHLWVSDWVQPS 710

  Fly   644 -------------------------------------------QKKSDGNNSTQ----------- 654
                                                       :|:.|.||.|.
Frog   711 LIRIEKRNTQNWVRLRGNMQRPSSVVIVHPLAKPVIADDIPLPRKEKDSNNQTAHSESFFPGPLS 775

  Fly   655 -----------------------------CFDIDECQVIPGLCQQKCLNFWGGYRCTCNSGYQLG 690
                                         |.|| .|.:     ...|::...|.:|.|..|:.
Frog   776 TSNAEMGTREAPSSRNGLLAEIMVSDDSGCIDI-HCDI-----NAHCVSSEDGPKCQCLEGFT-- 832

  Fly   691 PDNRTCNDINECEVHKDYKLC---MGLCINTPGSYQCSCPRGYILAADMNTCRDVDECATDSINQ 752
            .:.|.|:||:||.:|  ...|   ...||:|.|.|.|.|..|||  .:...|.|:|||:..:  .
Frog   833 GNGRLCHDIDECSLH--IAACNPHQTECIDTEGGYICKCKYGYI--GNGLQCTDIDECSRGT--H 891

  Fly   753 VCTGRNDICTNIRGSYKCTTVN-----------------CPL---GYSID-------PEQKN-RC 789
            .| |.|.:|||..|:|.||..|                 |||   ||.::       ||.|: .|
Frog   892 TC-GENAVCTNTEGNYTCTCTNGFPGSAADCTGKTIIRECPLAYDGYCLNGGVCIHFPELKDYGC 955

  Fly   790 RQNLNFCEGEEC 801
            |....:. ||.|
Frog   956 RCVAGYV-GERC 966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31999	NP_001284712.1	vWFA	<189..227	CDD:294047	3/5 (60%)
		EGF_CA	251..293	CDD:238011	13/56 (23%)
		EGF_CA	328..>363	CDD:214542	8/38 (21%)
		EGF_CA	519..564	CDD:214542	14/68 (21%)
		EGF_CA	565..601	CDD:238011	7/42 (17%)
		EGF_CA	611..651	CDD:284955	7/132 (5%)
		vWFA	<655..695	CDD:294047	9/39 (23%)
		cEGF	678..701	CDD:289433	8/22 (36%)
		EGF_CA	698..>730	CDD:214542	13/34 (38%)
		cEGF	721..744	CDD:289433	8/22 (36%)
egf	NP_001106478.1	LY	152..194	CDD:214531	2/4 (50%)
		vWFA	<346..398	CDD:320736	24/57 (42%)
		FXa_inhibition	412..440	CDD:317114	2/27 (7%)
		FXa_inhibition	447..480	CDD:317114	7/46 (15%)
		LY	508..550	CDD:214531	7/41 (17%)
		LY	554..593	CDD:214531	10/40 (25%)
		Ldl_recept_b	615..654	CDD:278487	5/38 (13%)
		LY	638..680	CDD:214531	4/41 (10%)
		EGF_3	810..838	CDD:315598	7/34 (21%)
		EGF_3	851..880	CDD:315598	11/30 (37%)
		EGF_3	886..>914	CDD:315598	12/30 (40%)
		PHA02887	<927..>967	CDD:333467	13/41 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000