DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31999 and sned1

DIOPT Version :9

Sequence 1:	NP_001284712.1	Gene:	CG31999 / 43777	FlyBaseID:	FBgn0051999	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	XP_017212114.1	Gene:	sned1 / 100001751	ZFINID:	ZDB-GENE-100913-1	Length:	1374	Species:	Danio rerio

Alignment Length:	778	Identity:	176/778 - (22%)
Similarity:	264/778 - (33%)	Gaps:	248/778 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 ITDEGELPFVSEEDMNVT----IVLTGDDDICGKIENLCAHICENTFDAYQCKCHPGFMLDNNNV 226
            ||| |||.|...:..|:|    :..|...|:.| :..:.|....|..|..:....||...|  ::
Zfish   175 ITD-GELSFTIFQYHNITWTTGMHATSGGDLAG-LGGIAAQAGFNAGDGKRYFNIPGSRTD--DI 235

  Fly   227 TCSPMKTQICPSGYNLDKLDNKCIDIDECREDLHDCKSSQYCHNTNGGYHCLNVKEKECPPGFHY 291
            ......|.:...|..:.::|:..:.:..|.:....|.:.:.|.|   |..|::    :|..|
Zfish   236 VEIETTTNVGYPGRWVFRIDDSHVQVGGCNDSASVCANLRPCRN---GGRCID----DCITG--- 290

  Fly   292 DHDYDACKDDYKCKDRKCVKIQSCDKGFSLHNGTCS-DIDECSHKSLNNCHVNSNQECVNTVGSY 355
                   ...:.|         ||..||:  ...|. ::||||.....|     ...||:.:..:
Zfish   291 -------NPSFTC---------SCLAGFT--GRRCQIEVDECSSYPCQN-----GGTCVDKINHF 332

  Fly   356 SCNCLPGFNLDATLNKCVDINECSINNHNCLPTQRCDNTIGSYICTRLQSCGTGYTLNAETG-NC 419
            .|.|..|| :.||..  .||:||  ....||...:|...:|::.|    .|..||     || .|
Zfish   333 ICLCPVGF-IGATCE--TDIDEC--QETPCLNGAQCIQGVGNFTC----KCQAGY-----TGFLC 383

  Fly   420 DDD-DEC----TLSTHNCP---SNYDC---HNTRGSFRCYRKISTMLTTRTTSTTVPPLSLENAR 473
            :.| :||    .|:...|.   :||.|   .|..|| .|..::........|.:.|..:..::..
Zfish   384 ESDINECMSVPCLNGGVCEDLVNNYTCTCTANFTGS-ACETELVVADAANQTESCVGEICNKHQI 447

  Fly   474 RSFTSRYPYPLAVHPEYSQNNDSISTNRRVDCSPGFYRNTL---------GACIDTN---EC--- 523
            ..:|:                   |.|....|.||:|.:..         |.|:|.|   :|
Zfish   448 CEYTN-------------------SGNYSCTCMPGYYGDNCEEECPCQNGGICVDVNGTCDCPTG 493

  Fly   524 ---------MEQNPCGNHE------RCINTNGHFRCESLLQCSPG-------YKSTVDGKSCIDI 566
                     :.|.||.|:.      .|:...|.:.|    .|..|       :...|..:|..|.
Zfish   494 FTGLYCQFEVTQTPCSNNRPCPDGGPCLEYGGTYLC----TCQTGAEFDHKDFYPYVQPQSACDS 554

  Fly   567 DECDTGEHNCGERQICRNRNGGFVCSCPIGH------ELKRSIGGASTCVDTNECALE----QRV 621
            ..|..|.:       |..|:|.::|.|..|:      .::.||..:|.|.:...|..|    ..|
Zfish   555 SPCQNGGY-------CYERDGDYICECKHGYRGKHCERVRLSICASSPCRNGGSCKEEADSYHCV 612

  Fly   622 CPL----------------------NAQCFNTIGAYYCECKAGFQKK----SDGNN----STQC- 655
            ||.                      ...||:.||.|.|||...|..:    :.|:|    ...|
Zfish   613 CPYRFTGKHCEVGKPDPCASSPCRNGGTCFHYIGKYKCECSPSFMGRHCEINRGSNPALEGLDCG 677

  Fly   656 -------FDIDECQVIPG-----LCQQKCLNFWGGYR---------CTCNSGYQLGPDNRTCNDI 699
                   .::......||     ||..       ||.         |:....:...|   .|.:|
Zfish   678 PPVKAKHAEVQYSSTTPGSMALYLCHP-------GYTPLTRATQIICSSQGSWSQPP---VCEEI 732

  Fly   700 NECEVHKDYKLCM--GLCINTPGSYQCSCPRGYILAADMNTCR-DVDECATDSINQVCTGRNDIC 761
            |||....    ||  |.|.:...||.|.|..|:    ....|: |:|||.::......|     |
Zfish   733 NECLSQP----CMNGGTCRDRVASYLCECEEGF----TGQRCQTDMDECLSEPCKHGST-----C 784

  Fly   762 TNIRGSYKCTTVNCPLGYS---IDPEQ----KNRC----------RQNLNFCE----GEECYT 803
            .:..|||.|   :|..||:   .:.||    .|.|          |.:|..|:    |:.|.|
Zfish   785 EDQPGSYFC---HCQEGYAGQDCEMEQDGCEPNPCLNGGICRGYRRNHLCVCKEGYIGDRCQT 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31999	NP_001284712.1	vWFA	<189..227	CDD:294047	8/37 (22%)
		EGF_CA	251..293	CDD:238011	8/41 (20%)
		EGF_CA	328..>363	CDD:214542	9/34 (26%)
		EGF_CA	519..564	CDD:214542	14/72 (19%)
		EGF_CA	565..601	CDD:238011	9/41 (22%)
		EGF_CA	611..651	CDD:284955	15/69 (22%)
		vWFA	<655..695	CDD:294047	9/61 (15%)
		cEGF	678..701	CDD:289433	6/31 (19%)
		EGF_CA	698..>730	CDD:214542	12/33 (36%)
		cEGF	721..744	CDD:289433	7/23 (30%)
sned1	XP_017212114.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000