DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Crk and Grb2

DIOPT Version :10

Sequence 1:NP_651908.1 Gene:Crk / 43775 FlyBaseID:FBgn0024811 Length:271 Species:Drosophila melanogaster
Sequence 2:NP_110473.2 Gene:Grb2 / 81504 RGDID:619758 Length:217 Species:Rattus norvegicus


Alignment Length:160 Identity:43/160 - (26%)
Similarity:76/160 - (47%) Gaps:19/160 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 WYFGPMSRQDATEVLMNERERGVFLVRDSNSIAGDYVLCVREDTKVSNYIINKVQQQDQIVYRIG 76
            |:||.:.|..|.|:|..:|..|.||:|:|.|..||:.|.|:....|.::   ||.:.....|.:.
  Rat    60 WFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHF---KVLRDGAGKYFLW 121

  Fly    77 DQSFDNLPKLLTFYTLHYLDTTPLKRPA---CRRVEKVIGK-------FDFVGSDQDDLPFQRGE 131
            ...|::|.:|:.::.     :|.:.|..   .|.:|:|..:       |||...:..:|.|:||:
  Rat   122 VVKFNSLNELVDYHR-----STSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGD 181

  Fly   132 VLTIVRKDEDQWWTARNSSGKIGQIPVPYI 161
            .:.::...:..||... ..|:.|..|..|:
  Rat   182 FIHVMDNSDPNWWKGA-CHGQTGMFPRNYV 210

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CrkNP_651908.1 SH2_CRK_like 4..108 CDD:198180 28/98 (29%)
SH3_CRK_N 109..163 CDD:212692 15/60 (25%)
SH3_CRK_C 201..257 CDD:212693
Grb2NP_110473.2 SH3_GRB2_N 1..56 CDD:212879
SH2_Grb2_like 56..150 CDD:199828 27/97 (28%)
SH3_GRB2_C 160..212 CDD:212882 13/52 (25%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.