DRSC/TRiP Functional Genomics Resources

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Protein Alignment Crk and ZAP70

DIOPT Version :10

Sequence 1:NP_651908.1 Gene:Crk / 43775 FlyBaseID:FBgn0024811 Length:271 Species:Drosophila melanogaster
Sequence 2:XP_054188971.1 Gene:ZAP70 / 7535 HGNCID:12858 Length:707 Species:Homo sapiens


Alignment Length:196 Identity:45/196 - (22%)
Similarity:79/196 - (40%) Gaps:35/196 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 WYFGPMSRQDATEVL-MNERERGVFLVRDSNSIAGDYVLCVREDTKVSNYIINKVQQQDQIVYRI 75
            :::|.:||.:|.|.| :.....|:||:|......|.|||.:..|.:..::   .:::|....|.|
Human    98 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHF---PIERQLNGTYAI 159

  Fly    76 -GDQSFDNLPKLLTFYTLHYLDTTP--LKRPACRR---VEKVIGKFDFVGSDQDDLPFQRGEVLT 134
             |.::.....:|..||: ...|..|  |::| |.|   :|...|.||.:..             .
Human   160 AGGKAHCGPAELCEFYS-RDPDGLPCNLRKP-CNRPSGLEPQPGVFDCLRD-------------A 209

  Fly   135 IVRKDEDQWWTARNSSGKIGQIPVPYIQQYDDYMDEDAIDKNEPSISGSSNVFESTLKRTDLNRK 199
            :||....|.|.....:  :.|..:....|.:..:...|.::        ...:.|:|.|.:..||
Human   210 MVRDYVRQTWKLEGEA--LEQAIISQAPQVEKLIATTAHER--------MPWYHSSLTREEAERK 264

  Fly   200 L 200
            |
Human   265 L 265

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CrkNP_651908.1 SH2_CRK_like 4..108 CDD:198180 28/102 (27%)
SH3_CRK_N 109..163 CDD:212692 9/53 (17%)
SH3_CRK_C 201..257 CDD:212693 45/196 (23%)
ZAP70XP_054188971.1 SH2_N-SH2_Zap70_Syk_like 96..199 CDD:198191 29/105 (28%)
SH2_C-SH2_Zap70 240..343 CDD:198265 7/34 (21%)
PTKc_Zap-70 421..689 CDD:270686
Blue background indicates that the domain is not in the aligned region.

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