DRSC/TRiP Functional Genomics Resources

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Protein Alignment Crk and BTK

DIOPT Version :10

Sequence 1:NP_651908.1 Gene:Crk / 43775 FlyBaseID:FBgn0024811 Length:271 Species:Drosophila melanogaster
Sequence 2:NP_001274273.1 Gene:BTK / 695 HGNCID:1133 Length:693 Species:Homo sapiens


Alignment Length:209 Identity:46/209 - (22%)
Similarity:84/209 - (40%) Gaps:60/209 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDTFDVSDRNSWYF------GPMSRQDATEVLMNERERGVFLVRD---SNS-----------IAG 45
            |:...:.:|..:.|      ||:.....||.|   |:|.:..:::   .||           |.|
Human   123 MEQISIIERFPYPFQVVYDEGPLYVFSPTEEL---RKRWIHQLKNVIRYNSDLVQKYHPCFWIDG 184

  Fly    46 DYVLCVREDTKVSNYIINKVQQQDQIVYRIGDQSFDNLPKLLTFYTLHY-----LDTTP-----L 100
            .| ||..:..|.:                :|.|..:|....|...:.|.     |..||     |
Human   185 QY-LCCSQTAKNA----------------MGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQIL 232

  Fly   101 KRP----------ACRRVEKVIGKFDFVGSDQDDLPFQRGEVLTIVRKDEDQWWTARNSSGKIGQ 155
            |:|          :...::||:..:|::..:.:||..::|:...|:.:....||.||:.:|:.|.
Human   233 KKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGY 297

  Fly   156 IPVPYIQQYDDYMD 169
            ||..|:.:.:|.::
Human   298 IPSNYVTEAEDSIE 311

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CrkNP_651908.1 SH2_CRK_like 4..108 CDD:198180 28/143 (20%)
SH3_CRK_N 109..163 CDD:212692 16/53 (30%)
SH3_CRK_C 201..257 CDD:212693
BTKNP_001274273.1 PH_Btk 40..200 CDD:269944 19/96 (20%)
SH3_BTK 251..305 CDD:212839 16/53 (30%)
SH2_Tec_Btk 308..413 CDD:198260 1/4 (25%)
PTKc_Btk_Bmx 431..686 CDD:173657
Blue background indicates that the domain is not in the aligned region.

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