DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Crk and Crk

DIOPT Version :9

Sequence 1:	NP_651908.1	Gene:	Crk / 43775	FlyBaseID:	FBgn0024811	Length:	271	Species:	Drosophila melanogaster
Sequence 2:	NP_062175.1	Gene:	Crk / 54245	RGDID:	2405	Length:	304	Species:	Rattus norvegicus

Alignment Length:	304	Identity:	133/304 - (43%)
Similarity:	175/304 - (57%)	Gaps:	61/304 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FDVSDRNSWYFGPMSRQDATEVLMNERERGVFLVRDSNSIAGDYVLCVREDTKVSNYIINKVQQQ 68
            ||..:|:|||:|.:|||:|..:|..:| .||||||||::..|||||.|.|:::||:||||....:
  Rat     5 FDSEERSSWYWGRLSRQEAVALLQGQR-HGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPR 68

  Fly    69 DQIV--------------YRIGDQSFDNLPKLLTFYTLHYLDTTPLKRPACR------------R 107
            ..:.              .|||||.||:||.||.||.:||||||.|..|..|            .
  Rat    69 PPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSRSRQGSGVILRQEE 133

  Fly   108 VEKVIGKFDFVGSDQDDLPFQRGEVLTIVRKDEDQWWTARNSSGKIGQIPVPYIQQYDDYMDEDA 172
            .|.|...|||.|:|::||||::|::|.|..|.|:|||.|.:|.||.|.|||||:::|
  Rat   134 AEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKY-------- 190

  Fly   173 IDKNEPSISGSSNVFESTLK----------------RTDLNRKL------PAYARVKQSRVPNAY 215
                .|:.:..|.:.....:                :..:|..|      |.||||.|.||||||
  Rat   191 ----RPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYARVIQKRVPNAY 251

  Fly   216 DKTALKLEIGDIIKVTKTNINGQWEGELNGKNGHFPFTHVEFVD 259
            |||||.||:|:::||||.|::||||||.|||.||||||||..:|
  Rat   252 DKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLD 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Crk	NP_651908.1	SH2_CRK_like	4..108	CDD:198180	56/129 (43%)
		SH3_CRK_N	109..163	CDD:212692	29/53 (55%)
		SH3_CRK_C	201..257	CDD:212693	42/55 (76%)
Crk	NP_062175.1	SH2_CRK_like	5..122	CDD:198180	62/142 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	61..85		11/37 (30%)
		SH3_CRK_N	135..189	CDD:212692	19/53 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..229		21/33 (64%)
		SH3_CRK_C	237..293	CDD:212693	18/24 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338800
Domainoid	1	1.000	95	1.000	Domainoid score	I7245
eggNOG	1	0.900	-	-		E1_KOG4792
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H81850
Inparanoid	1	1.050	242	1.000	Inparanoid score	I3238
OMA	1	1.010	-	-		QHG52661
OrthoDB	1	1.010	-	-		D1414461at2759
OrthoFinder	1	1.000	-	-		FOG0003539
OrthoInspector	1	1.000	-	-		otm44519
orthoMCL	1	0.900	-	-		OOG6_105421
Panther	1	1.100	-	-	O	PTHR19969
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2415
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770