DRSC/TRiP Functional Genomics Resources

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Protein Alignment Crk and grb2a

DIOPT Version :10

Sequence 1:NP_651908.1 Gene:Crk / 43775 FlyBaseID:FBgn0024811 Length:271 Species:Drosophila melanogaster
Sequence 2:NP_001007770.1 Gene:grb2a / 493609 ZFINID:ZDB-GENE-041121-1 Length:217 Species:Danio rerio


Alignment Length:165 Identity:43/165 - (26%)
Similarity:75/165 - (45%) Gaps:15/165 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 WYFGPMSRQDATEVLMNERERGVFLVRDSNSIAGDYVLCVREDTKVSNYIINKVQQQDQIVYRIG 76
            |::|.:.|..|.|:|..:|..|.||:|:|.|..||:.|.|:....|.::   ||.:.....|.:.
Zfish    60 WFYGKIPRAKAEEMLNKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHF---KVLRDGAGKYFLW 121

  Fly    77 DQSFDNLPKLLTFYTLHYLDTTPLKRPA-CRRVEK-------VIGKFDFVGSDQDDLPFQRGEVL 133
            ...|::|..|:.:   |...:....:|. .|.:|:       |...|||...:..:|.|:||:.:
Zfish   122 VVKFNSLNSLVDY---HRSTSVSRNQPIFLRDIEQVPQNSTYVQALFDFDPQEDGELGFRRGDFI 183

  Fly   134 TIVRKDEDQWWTARNSSGKIGQIPVPYIQQYDDYM 168
            .::...:..||... ..|:.|..|..|:...:..|
Zfish   184 QVLDNSDPNWWKGA-CHGQTGMFPRNYVTPVNQNM 217

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CrkNP_651908.1 SH2_CRK_like 4..108 CDD:198180 27/96 (28%)
SH3_CRK_N 109..163 CDD:212692 15/60 (25%)
SH3_CRK_C 201..257 CDD:212693
grb2aNP_001007770.1 SH3_GRB2_N 1..56 CDD:212879
SH2_Grb2_like 56..150 CDD:199828 26/95 (27%)
SH3_GRB2_C 160..212 CDD:212882 14/52 (27%)
Blue background indicates that the domain is not in the aligned region.

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