Protein Alignment Crk and zap70

DIOPT Version :10

• Sequence 1: NP_651908.1
• Gene: Crk / 43775
• FlyBaseID: FBgn0024811
• Length: 271
• Species: Drosophila melanogaster
• Sequence 2: NP_001006825.1
• Gene: zap70 / 448557
• XenbaseID: XB-GENE-956409
• Length: 609
• Species: Xenopus tropicalis
• Alignment Length: 257
• Identity: 57/257 - (22%)
• Similarity: 93/257 - (36%)
• Gaps: 83/257 - (32%)

  Fly     5 DVSDRNSWYFGPMSRQDATEVL-MNERERGVFLVRDSNSIAGDYVLCVREDTKVSNYIINKVQQQ 68
            |.:....:|:|.:||.||.|.| :.....|:||:|......|.|||.:..:....:|   .|::|
 Frog     3 DAAGHLPFYYGSISRADAEEYLKLGGMMDGLFLLRQCLRTLGGYVLSMVYNLHFHHY---PVERQ 64

  Fly    69 DQIVYRI-GDQSFDNLPKLLTFY---------TLHYLDTTPLKRPACRRVEKVIGKFDFVGSDQD 123
            ....|.| |.::.....:|..:|         ||.    .|..|||  .||...|.||   :.:|
 Frog    65 LNGTYAIAGGKAHCGPAELCEYYSKDADGLCCTLR----RPCNRPA--GVECQAGVFD---NMRD 120

  Fly   124 DLPFQRGEVLTIVRKDEDQWWTARNSSGKIGQIPVPYIQQYDDYMDEDAIDKNEPSISGSSNV-- 186
            ::          :|:...|.|.                      ::.||::  :..||.:..|
 Frog   121 NM----------MREYVRQTWK----------------------LEGDALE--QAIISQAPQVEK 151

  Fly   187 ------------FESTLKRTDLNRKLPAYAR-----VKQSRVPNA-------YDKTALKLEI 224
                        :..|:.|.:..|||.:.|:     :.:.|..|.       |.||....:|
 Frog   152 LIATTAHERMAWYHGTISRDEAERKLYSGAQPDGKFLMRERKENGTYALSVMYGKTVYHYKI 213

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Crk	NP_651908.1	SH2_CRK_like	4..108	CDD:198180	31/113 (27%)
		SH3_CRK_N	109..163	CDD:212692	8/53 (15%)
		SH3_CRK_C	201..257	CDD:212693	7/36 (19%)
zap70	NP_001006825.1	SH2_N-SH2_Zap70_Syk_like	8..111	CDD:198191	32/111 (29%)
		SH2_C-SH2_Zap70	152..256	CDD:198265	12/62 (19%)
		Protein Kinases, catalytic domain	321..589	CDD:473864