DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Crk and crk

DIOPT Version :9

Sequence 1:	NP_651908.1	Gene:	Crk / 43775	FlyBaseID:	FBgn0024811	Length:	271	Species:	Drosophila melanogaster
Sequence 2:	NP_001003628.1	Gene:	crk / 445234	ZFINID:	ZDB-GENE-040801-148	Length:	311	Species:	Danio rerio

Alignment Length:	300	Identity:	137/300 - (45%)
Similarity:	177/300 - (59%)	Gaps:	46/300 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FDVSDRNSWYFGPMSRQDATEVLMNERERGVFLVRDSNSIAGDYVLCVREDTKVSNYIINKVQQQ 68
            ||..||.|||:|.:|||:|..:|..:| .||||||||.:|.|||||.|.|::|||:||||.:...
Zfish     5 FDSEDRGSWYWGRLSRQEAVSLLQGQR-HGVFLVRDSITIPGDYVLSVSENSKVSHYIINSISSN 68

  Fly    69 DQI-------VYRIGDQSFDNLPKLLTFYTLHYLDTTPLKRPACR------------------RV 108
            .|.       .:|||||.||.||.||.||.:||||||.|..|..:                  |:
Zfish    69 RQSGPGLAPPRFRIGDQEFDALPALLEFYKIHYLDTTTLIEPISKSKHSSFISVNAGTGGAPPRL 133

  Fly   109 EK--VIGKFDFVGSDQDDLPFQRGEVLTIVRKDEDQWWTARNSSGKIGQIPVPYIQQY------- 164
            |:  |...|||.|:|.:||||::|:||.::.|.|:|||.|:||.|::|.|||||:::|
Zfish   134 EEEYVRALFDFPGNDDEDLPFRKGDVLRVLEKPEEQWWNAQNSEGRVGMIPVPYVEKYRPASPTS 198

  Fly   165 ----------DDYMDEDAIDKNEPSISGSSNVFESTLKRTDLNRKLPAYARVKQSRVPNAYDKTA 219
                      ..:.:.|......|.:.|....:.......:|... |.|||..|.||||||||||
Zfish   199 GAPGVSVSGSGAHGNSDGHSTQSPPLLGEPGQYAQPTSLPNLQNG-PVYARAIQKRVPNAYDKTA 262

  Fly   220 LKLEIGDIIKVTKTNINGQWEGELNGKNGHFPFTHVEFVD 259
            |.||:||::||||.|:|||||||..||:||||||||..:|
Zfish   263 LALEVGDMVKVTKINVNGQWEGECKGKHGHFPFTHVRLLD 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Crk	NP_651908.1	SH2_CRK_like	4..108	CDD:198180	59/128 (46%)
		SH3_CRK_N	109..163	CDD:212692	29/55 (53%)
		SH3_CRK_C	201..257	CDD:212693	42/55 (76%)
crk	NP_001003628.1	SH2_CRK_like	5..115	CDD:198180	59/110 (54%)
		SH3_CRK_N	136..190	CDD:212692	28/53 (53%)
		SH3_CRK_C	244..300	CDD:212693	42/55 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578402
Domainoid	1	1.000	95	1.000	Domainoid score	I7365
eggNOG	1	0.900	-	-		E1_KOG4792
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H81850
Inparanoid	1	1.050	255	1.000	Inparanoid score	I3154
OMA	1	1.010	-	-		QHG52661
OrthoDB	1	1.010	-	-		D1414461at2759
OrthoFinder	1	1.000	-	-		FOG0003539
OrthoInspector	1	1.000	-	-		otm24387
orthoMCL	1	0.900	-	-		OOG6_105421
Panther	1	1.100	-	-	O	PTHR19969
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5267
SonicParanoid	1	1.000	-	-		X2415
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800